Modern electroanalytical chemistry, based on an intimate coupling of electrochemical techniques and spectroscopic and imaging methodologies, contains a broad range of very powerful research tools that are invariably characterized by descriptors of in situ, in vivo, real-time, online, etc. This Perspective offers a viewpoint of the authors on part of the grand challenges facing society and our planet in the 21st century, where contemporary analysts, armed with modern electroanalytical chemistry, have the ability to tackle these challenges with unprecedented levels. Prominent research topics such as energy, environment and biology are highlighted to manifest the capability and indispensability of modern electroanalytical chemistry when addressing these pressing challenges and beyond.