A mesenchymal to epithelial switch in Fgf10 expression specifies an evolutionary-conserved population of ionocytes in salivary glands

Mauduit, Olivier; Aure, Marit H.; Delcroix, Vanessa; Basova, Liana V.; Srivastava, Amrita; Umazume, Takeshi; Mays, Jacqueline W.; Bellusci, Saverio; Tucker, Abigail S.; Hajihosseini, Mohammad K.; Hoffman, Matthew P.; Makarenkova, Helen P.

doi:10.1016/j.celrep.2022.110663

Cited by 23 publications

(24 citation statements)

References 104 publications

(126 reference statements)

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“…In murine, SMG is the largest glands (∼75 % mass of all SGs), followed by PG (∼15 %) and SLG (∼8%). The scRNA-seq approach has been adopted to analyze the cell types and their changes in SMG during SG development or in response to the condition of Sjögren’s Syndrome (SS) [1] , [7] , [8] , [10] , [32] . For PG, one murine report determined the cell types for young mouse (18 days postnatal) based on 492 cells characterized [8] , and a recent report identified 10 cell types in human parotid with majority of cells being T and B cells [6] .…”

Section: Resultsmentioning

confidence: 99%

“…S5 B). Annotation of these 17 clusters with feature genes [1] , [7] , [8] , [9] , [10] , [32] , [33] , [34] , [35] , [36] , [37] (Supplementary Table S12 and S13 ) identified serous (cluster 4), seromucous (cluster 6) and mucous (cluster 11) three types of acinar cells, and striated (cluster 1), intercalated (cluster 7), excretory (cluster 8) and GCT (cluster 9) four types of ductal cells ( Fig. 7 A, Supplementary Fig.…”

Section: Resultsmentioning

confidence: 99%

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Bulk RNA-seq and scRNA-seq analysis reveal an activation of immune response and compromise of secretory function in major salivary glands of obese mice

Huang

Gao

Wang

et al. 2023

Computational and Structural Biotechnology Journal

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Bulk RNA-seq and scRNA-seq analysis reveal an activation of immune response and compromise of secretory function in major salivary glands of obese mice

Huang

Gao

Wang

et al. 2023

Computational and Structural Biotechnology Journal

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“…FGF10 is involved in the formation of lacrimal and salivary glands at the embryonic period ( Prochazkova et al, 2018 ; Karasawa et al, 2022 ) by regulating the progenitor cell population and stimulating gland outgrowth ( Chatzeli, Gaete & Tucker, 2017 ). In adults, FGF10 is critical in maintaining gland homeostasis and/or regeneration ( Mauduit et al, 2022 ).…”

Section: Survey Methodologymentioning

confidence: 99%

Phenotypic spectrum of FGF10-related disorders: a systematic review

Bzdega¹,

Karolak²

2022

PeerJ

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FGF10, as an FGFR2b-specific ligand, plays a crucial role during cell proliferation, multi-organ development, and tissue injury repair. The developmental importance of FGF10 has been emphasized by the identification of FGF10 abnormalities in human congenital disorders affecting different organs and systems. Single-nucleotide variants in FGF10 or FGF10-involving copy-number variant deletions have been reported in families with lacrimo-auriculo-dento-digital syndrome, aplasia of the lacrimal and salivary glands, or lethal lung developmental disorders. Abnormalities involving FGF10 have also been implicated in cleft lip and palate, myopia, or congenital heart disease. However, the exact developmental role of FGF10 and large phenotypic heterogeneity associated with FGF10 disruption remain incompletely understood. Here, we review human and animal studies and summarize the data on FGF10 mechanism of action, expression, multi-organ function, as well as its variants and their usefulness for clinicians and researchers.

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“… 25 Notably, it is largely expressed first in mesenchyme and then in epithelial cells in murine salivary glands, in a strictly time-controlled fashion. 26 Makarenkova et al 25 demonstrated that FGF10 is an inducer for LG development in mouse embryos.…”

Section: Anatomic Anomaly: Lg Aplasia or Hypoplasia Associated With S...mentioning

confidence: 99%

“…Patients affected with this syndrome exhibit skull defects, sometimes in combination with encephalocele, wide nasal bridge, notched nares, depressed nasal tip, hypertelorism, and alopecia, sometimes associated with alacrimia. 26 …”

Section: Anatomic Anomaly: Lg Aplasia or Hypoplasia Associated With S...mentioning

confidence: 99%

Hypolacrimia and Alacrimia as Diagnostic Features for Genetic or Congenital Conditions

Willems

Wells

Coubes

et al. 2022

Invest. Ophthalmol. Vis. Sci.

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As part of the lacrimal apparatus, the lacrimal gland participates in the maintenance of a healthy eye surface by producing the aqueous part of the tear film. Alacrimia and hypolacrimia, which are relatively rare during childhood or young adulthood, have their origin in a number of mechanisms which include agenesia, aplasia, hypoplasia, or incorrect maturation of the gland. Moreover, impaired innervation of the gland and/or the cornea and alterations of protein secretion pathways can lead to a defective tear film. In most conditions leading to alacrimia or hypolacrimia, however, the altered tear film is only one of numerous defects that arise and therefore is commonly disregarded. Here, we have systematically reviewed all of those genetic conditions or congenital disorders that have alacrimia or hypolacrimia as a feature. Where it is known, we describe the mechanism of the defect in question. It has been possible to clearly establish the physiopathology of only a minority of these conditions. As hypolacrimia and alacrimia are rare features, this review could be used as a tool in clinical genetics to perform a quick diagnosis, necessary for appropriate care and counseling.

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A mesenchymal to epithelial switch in Fgf10 expression specifies an evolutionary-conserved population of ionocytes in salivary glands

Cited by 23 publications

References 104 publications

Bulk RNA-seq and scRNA-seq analysis reveal an activation of immune response and compromise of secretory function in major salivary glands of obese mice

Bulk RNA-seq and scRNA-seq analysis reveal an activation of immune response and compromise of secretory function in major salivary glands of obese mice

Phenotypic spectrum of FGF10-related disorders: a systematic review

Hypolacrimia and Alacrimia as Diagnostic Features for Genetic or Congenital Conditions

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