A Meta-Analysis on the Relationship Between Hair Dye and the Incidence of Non-Hodgkin’s Lymphoma

Abstract

Background: Epidemiologic studies have suggested hair dye to be a risk factor for many cancers. However, previous studies on the association between the personal use of hair dye and risk of non-Hodgkin’s lymphoma (NHL) have been inconclusive. Methods: The PubMed, Embase, Cochrane Library, and Web of Science databases, as well as the references cited in included studies, were searched for relevant studies up to February 10, 2015. Odds ratios (OR) with 95% confidence intervals (CI) were applied to assess the strength of the association. Publication bias was evaluated using a funnel plot by Egger’s and Begg’s tests. Results: A total of 16 studies were included in the analysis, including 13 case-control studies and 3 cohort studies. The present meta-analysis results revealed that the risk of NHL in a high population of hair dye users was 14% (OR 1.14, 95% CI 1.01–1.29). Furthermore, individuals who used more than 20 pack-years of hair dye had increased risk of NHL. Conclusion: The outcomes indicate that hair dye use increases the risk of NHL, especially for females. Hence, people who frequently use hair dyes or have been using hair dyes for more than 20 years should minimize their exposure to hair dye products to prevent the risk of NHL.

Cosmetics’ Safety: Gray Areas with Darker Inside

“…Park et al, 2019 reported that volatile organic compounds (VOCs) and phthalates concentrations of sanitary pads and diapers were significantly higher than those found in common commercial was used in more than 80% of permanent dyes, is frequently reported to cause vascular neuroedema, acute renal failure or bladder cancer [47] . Qin et al, 2019 reported that hair dye use increases the risk of non-Hodgkin's lymphoma, especially for females [48] . OTC use of cosmetic lenses is rapidly increasing.…”

Cosmetics’ Safety: Gray Areas with Darker Inside-Mini Review

“…p-Phenylenediamine (PPD), which was used in more than 80% of permanent dyes, is frequently reported to cause vascular neuroedema, acute renal failure or bladder cancer [47]. Qin et.al, 2019 reported that hair dye use increases the risk of non-Hodgkin's lymphoma, especially for females [48]. OTC use of cosmetic lenses is rapidly increasing.…”