A meta-analysis: The association between interleukin-17 pathway gene polymorphism and gastrointestinal diseases

Jiang, Yuxing; Li, Gao-Ming; Yi, Dong; Yu, Ping

doi:10.1016/j.gene.2015.07.018

Cited by 6 publications

(4 citation statements)

References 45 publications

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“…In addition, to evaluate whether significant associations (P < 0.05) detected in the present study are “noteworthy”, we further calculated the FPRP value at a probability level of 0.001 and an OR of 1.5 58 . As suggested by the previous study 59 , we set a FPRP cut-off value of 0.2, and only FPRP results < 0.2 were considered to be “noteworthy”.…”

Section: Methodsmentioning

confidence: 99%

The SDF-1 rs1801157 Polymorphism is Associated with Cancer Risk: An Update Pooled Analysis and FPRP Test of 17,876 Participants

Xiang

Deng

et al. 2016

Sci Rep

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The stromal cell derived factor-1 (SDF-1) rs1801157 gene polymorphism has been implicated in susceptibility to cancer, but the results were inconclusive. The current study was to precisely investigate the association between SDF-1 rs1801157 polymorphism and cancer risk using meta-analysis and the false positive report probability (FPRP) test. All 17,876 participants were included in the study. The meta-analysis results indicated a significant association between the SDF-1 rs1801157 polymorphism and cancer risk. By subgroup analyses, the results detected that the SDF-1 rs1801157 polymorphism was associated with cancer susceptibility among Asians and Caucasians. Additionally, we also found significant associations between the SDF-1 rs1801157 polymorphism and susceptibility to different types of cancer. However, to avoid a “false positive report”, we further investigated the significant associations observed in the present meta-analysis using the FPRP test. Interestingly, the results of the FPRP test indicated that only 4 gene models were truly associated with cancer risk, especially in Asians. Moreover, we confirmed that the SDF-1 rs1801157 gene polymorphism was only associated with lung and urologic cancer risk. In summary, this study suggested that the SDF-1 rs1801157 polymorphism may serve as a risk factor for cancer development among Asians, especially an increased risk of urologic and lung cancers.

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Section: Methodsmentioning

confidence: 99%

The SDF-1 rs1801157 Polymorphism is Associated with Cancer Risk: An Update Pooled Analysis and FPRP Test of 17,876 Participants

Xiang

Deng

et al. 2016

Sci Rep

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“…This SNP has been extensively studied due to its potential association with different diseases in different ethnic populations. Previous studies with r3748067 in various diseases are asthma, 55 breast cancer, 44 cervical cancer, 56,57 CRC, 40,58 congestive heart failure, 59 coronary artery disease, 60,61 gastric cancer, 30,62 gastrointestinal diseases, 63 rheumatoid arthritis, 64 laryngeal cancer, 65 lung cancer, 66 otitis, 67 pneumoconiosis, 68 psoriasis, 69 tuberculosis, [70][71][72] ulcerative colitis, 73 and viral myocarditis. 74 The connection between IL-17A rs3748067 genetic variant and susceptibility of CRC has been studied for the first time in 2018.…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms in IL-17A Gene and Susceptibility of Colorectal Cancer in Bangladeshi Population: A Case-Control Analysis

et al. 2022

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Objective Interleukin-17A ( IL-17A) genetic polymorphisms are associated with multiple cancer types, including colorectal cancer (CRC). However, no previous study was performed in the Bangladeshi population to evaluate the association. Our study aimed to find the association between two IL-17A variants (rs10484879 C/A and rs3748067 G/A) and susceptibility of CRC. Methods and Materials This retrospective case-control study comprised 292 CRC patients and 288 age, sex, and BMI matched healthy volunteers. Genotyping of both variants was done by the tetra-primer ARMS-PCR method, and the results were analyzed by the SPSS software package (version-25.0). Results Logistic regression analysis indicated that in case of IL-17A rs10484879 polymorphism, AC and AA genotype carriers showed 2.44- and 3.27-times significantly increased risk for CRC development (OR = 2.44, P = .0008 and OR = 3.27, P = .0133, individually). A significant association was also observed for AC + AA genotype (OR = 2.58, P = .0001). Again, over-dominant and allelic model revealed statistically significant link to CRC risk (OR = 2.13, P = .0035 and OR = 2.22, P = .001). For rs3748067 polymorphism, AG and AA genotype carriers showed 2.30- and 2.45-times enhanced risk for CRC (OR = 2.30, P = .005 and OR = 2.45, P = .031). A statistically significant association was also observed for AG + AA genotype (OR = 2.35, P = .001), over-dominant model (OR = 2.05, P = .014), and allelic model (OR = 2.11, P = .0004). Conclusion This study highlights that IL-17A rs10484879 and rs3748067 polymorphisms may be associated with CRC development. However, further functional research with larger samples may reveal more statistically significant outcomes.

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“…To date, studies indicate that there are a few common SNPs in the human interleukin-17A gene associated with various diseases, e.g., cardiovascular (coronary artery disease) (11) and gastrointestinal diseases (12). Furthermore, some research has confirmed the association between the rs1974226 SNP in the IL-17A gene and altered susceptibility to gram-positive infections in patients with severe sepsis (13).…”

Section: Discussionmentioning

confidence: 99%

Identification of polymorphism in the bovine interleukin-17A gene and its association with mastitis in Polish Holstein–Friesian cattle

Dusza¹,

Pokorska²,

Kułaj³

et al. 2018

Turk J Vet Anim Sci

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IntroductionIntensive genetic selection in dairy cattle has resulted in a great increase in milk performance. In many countries, milk production per cow has more than doubled in the last 40 years (1). This has not been without effects on the welfare and health of the animals. The review by Ingvartsen et al.(2) revealed an unfavorable genetic correlation between milk yield and incidence of common bovine diseases like ketosis (0.26-0.65), ovarian cysts (0.23-0.42), mastitis (0.15-0.68), and lameness (0.24-0.48). Furthermore, the fertility of dairy cows has declined considerably in the last decades (3). Deteriorated reproductive performance and higher frequency of diseases at the beginning of lactation in high-milking cows may be connected to a negative energy balance resulting from insufficient dietary energy intake (4).Mastitis results in an immunological response characterized by rapid increase of the somatic cell count (mainly white blood cells: neutrophils, macrophages, and lymphocytes) in the milk (5). This response of the immune system depends on the action of inflammatory mediators like cytokines, chemokines, prostaglandins, and leukotrienes (6). Cytokines are key signaling molecules for communication in the immune system. The interleukin-17 (IL-17) family is a recently identified group of cytokines involved in the maintenance of homeostasis and host defense against bacterial infections. The prototype cytokine of IL-17 family is interleukin-17A, produced mainly by activated CD4+ T cells (but also by T cells, natural killer cells, lymphoid tissue inducer-like cells, and neutrophils); it plays a significant role in promoting inflammation by recruitment of neutrophils during infection (7). Reinard et al. (8) revealed that the production of IL-17A by CD4+ T cells is a predictor of the antigen-specific immune response of the cow mammary gland. The importance of IL-17 for mastitis occurrence was also demonstrated in the findings of Jing et al. (9), who observed the elevated level of this cytokine in the milk of goats experimentally infected with Escherichia coli or Staphylococcus aureus.However, research on interleukin-17A is still very scarce. In the present study, the genetic polymorphism within a bovine IL-17A gene was analyzed. The impact of the identified single nucleotide polymorphism (SNP) on the resistance or susceptibility to clinical mastitis and on the level of the somatic cell score (SCS) in Polish Holstein-Friesian cows was then examined.

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A meta-analysis: The association between interleukin-17 pathway gene polymorphism and gastrointestinal diseases

Cited by 6 publications

References 45 publications

The SDF-1 rs1801157 Polymorphism is Associated with Cancer Risk: An Update Pooled Analysis and FPRP Test of 17,876 Participants

The SDF-1 rs1801157 Polymorphism is Associated with Cancer Risk: An Update Pooled Analysis and FPRP Test of 17,876 Participants

Polymorphisms in IL-17A Gene and Susceptibility of Colorectal Cancer in Bangladeshi Population: A Case-Control Analysis

Identification of polymorphism in the bovine interleukin-17A gene and its association with mastitis in Polish Holstein–Friesian cattle

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