A metabolomic study on the effect of prenatal exposure to Benzophenone-3 on spontaneous fetal loss in mice

Han, Xiumei; Lu, Ting; Hu, Yanhui; Duan, Jiawei; Guan, Yusheng; Huang, Xiaomin; Zhou, Jingjing; Huang, Rui; Tang, Miaomiao; Sun, Rongli; Wang, Ying; Lee, Song; Xia, Yankai; Wang, Xinru; Chen, Minjian; Chen, Ting

doi:10.1016/j.ecoenv.2022.113347

Cited by 9 publications

(4 citation statements)

References 69 publications

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“…In animal studies, BPA exposure was associated with reduced embryo implantation ( 60 ). Benzophenone–3 may induce placental thrombosis and miscarriage ( 61 ). Maternal exposure to TiO2NPs was associated with increased atretic follicles, decreased mating and pregnancy rates ( 62 ), increased the number of stunted fetuses, and increased fetal mortality ( 63 ).…”

Section: Discussionmentioning

confidence: 99%

Associations of personal care products use with reproductive outcomes of IVF/ICSI treatment

Guo,

Yao,

Liu

et al. 2024

Front. Endocrinol.

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IntroductionPersonal care products (PCPs) contain a number of endocrine-disrupting chemicals (EDCs) that could potentially affect the reproductive function in women of childbearing age. However, studies focused on the effects of PCPs use on reproductive outcomes are very limited. The current study aimed to explore the relationships between PCPs use patterns and reproductive outcomes in women undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatment.MethodsA total of 1500 women from the Tongji Reproductive and Environmental (TREE) study between December 2018 and January 2020 were included in this study. Participants provided characteristics of PCPs use within the previous three months. Retrieved oocyte number, mature oocyte number, two distinct pronuclei (2PN) zygote number, fertilization rate, cleavage rate, blastocyst formation rate, implantation, clinical pregnancy, miscarriage, and live birth were followed up as reproductive endpoints. Generalized linear regression model was utilized to assess the associations between various categories of PCPs use and reproductive endpoints of IVF/ICSI.ResultsAfter adjusting for relevant covariates, women who used skin care products ≥14 times per week had a reduction of 22.4% in the maturation rate (95% CI: -39.2%, -1.6%) compared to participants who did not use skin care products. After transferring fresh embryos, women who used cosmetics 1–2 times per week (adjusted OR = 2.2, 95% CI: 1.0, 4.8) or 3–7 times per week (adjusted OR = 2.5, 95% CI: 1.2, 5.2) had a higher possibility of miscarriage than those who did not use cosmetics. There was negative association between the use of gel or soap and the cleavage rate among women aged < 30 years old (P for interaction = 0.01). Among women with BMI ≥ 24 kg/m2, the use of gel or soap was negatively associated with the blastocyst formation rate (P for interaction = 0.04), while cosmetics use was negatively associated with the maturation rate (P for interaction = 0.001).ConclusionOur findings suggest that the use of PCPs in women of reproductive age have a potential adverse impact on IVF/ICSI outcomes, particularly skin care and cosmetic products.

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Section: Discussionmentioning

confidence: 99%

Associations of personal care products use with reproductive outcomes of IVF/ICSI treatment

Guo,

Yao,

Liu

et al. 2024

Front. Endocrinol.

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“…The relationship between pesticides and reproductive toxicity has been revealed in many studies. Especially studies conducted with women working in agricultural fields support the hypothesis that there is a relationship between pesticides and SAB [3,4]. For example, the role of dichloro di phenyl tri chloro ethane (DDT) exposure in spontaneous pregnancy loss has been previously reported [5].…”

Section: Introductionmentioning

confidence: 93%

Investigation of single strand DNA breaks in spontaneous abortion cases with known pesticide exposure

Akgol,

Pektas

2023

Med-Science

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Pesticide exposure is an essential public health problem and endocrine-disrupting factor. Encounters during pregnancy may cause spontaneous abortions or congenital anomalies with embryotoxic or fetotoxic effects. DNA double-strand breaks occur upon exposure of DNA to radiation and chemicals or are caused by faulty DNA metabolic processes. This research examines the relationship of DNA single-strand amount with pesticides and their types. Single-stranded DNA (ssDNA) density was quantitatively determined by fluorometric method in the blood of Spontaneous Abortion with organochlorine and or organophosphate pesticide exposure and in the blood of two patient groups who had normal delivery without pesticide contact. The mutation was screened by next-generation sequencing in 4 women who experienced spontaneous abortion with a high pesticide amount and variety. 91 female patients aged 18-35 years were included in the study. The spontaneous abortion group was 56 (61.5%), and the normal delivery group was 35 (38%) women. The mean age was 28.18(±4.5). There was a significant correlation between Pentachlorophenol -52 (PCB52) and ssDNA level (p<0.05). There was no relationship between ssDNA ratios and groups (p>0.05). It was determined that ssDNA levels were higher among those with multiple abortions. The ssDNA level was higher in those who had an abortion before (p<0.05). We determined that dichloro di phenyl tri chloro ethane (DDT) and its congeners were significantly higher in the Whole Exome Sequence analysis of 2 of the four patients with the highest pesticide level. The DYNC2H1 gene NM_001377.3 c.7506G>A (p.Trp2502Ter) variation and the DYNC2H1 gene NM_001377.3 c.8458C>A (p.Pro2820Thr) variation associated with recurrent miscarriages were found to be heterozygous. Studies in this area need to be increased to determine the relationship of ssDNA elevation with pesticide exposure, its predictive value in abortion, and the value of environmental factors in repeated abortions whose etiology has not been clarified.

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“…Fertilization/spawning events may not be the only critical facet of an organism's life cycle. In corals, fish and mammals, environmentally relevant oxybenzone-exposure in utero or during embryonic development may result in disease, ranging from morbid deformities and bleaching in coral planulae to Hirschsprung Disease from exposure during the first trimester in mammals and abnormal development of the nervous system in fish (Downs et al, 2016;Huo et al, 2016;DiNardo and Downs, 2019;Wang et al, 2021;Han et al, 2022).…”

Section: Sunscreen Pollution Mitigation Optionsmentioning

confidence: 99%

Beach showers as sources of contamination for sunscreen pollution in marine protected areas and areas of intensive beach tourism in Hawaii, USA

Downs¹,

Díaz˗Cruz

White³

et al. 2022

Journal of Hazardous Materials

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A metabolomic study on the effect of prenatal exposure to Benzophenone-3 on spontaneous fetal loss in mice

Cited by 9 publications

References 69 publications

Associations of personal care products use with reproductive outcomes of IVF/ICSI treatment

Associations of personal care products use with reproductive outcomes of IVF/ICSI treatment

Investigation of single strand DNA breaks in spontaneous abortion cases with known pesticide exposure

Beach showers as sources of contamination for sunscreen pollution in marine protected areas and areas of intensive beach tourism in Hawaii, USA

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