A metal–organic framework-integrated composite for piezocatalysis-assisted tumour therapy: design, related mechanisms, and recent advances

Wang, Shuteng; Liu, Yifan; Quan, Chunhua; Luan, Shifang; Shi, Hengchong; Wang, Lei

doi:10.1039/d3bm01944f

Cited by 4 publications

(2 citation statements)

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“…Metal organic framework (MOF) has been widely used in biochemical field because of its controllable size and shape, large specific surface area, high porosity, stable structure, and good biosafety performance. [13][14][15][16][17] The stable crystal structure based on MOF allows it to integrate a large number of photosensitizers under light to produce highly cytotoxic ROS. [18][19][20] MOF constructed with photosensitizer as a ligand also can reduce the quenching of photosensitizer, and the porous structure can accelerate the diffusion of ROS.…”

Section: Introductionmentioning

confidence: 99%

Metal‐Organic Framework PCN‐224 Combined Cobalt Oxide Nanoparticles for Hypoxia Relief and Synergistic Photodynamic/Chemodynamic Therapy

Yuan,

Chen,

Geng

et al. 2024

Chemistry A European J

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Photodynamic therapy (PDT) and chemodynamic therapy (CDT) are promising tumor treatments mediated by reactive oxygen species (ROS), which have the advantages of being minimally invasive. However, the hypoxia of tumor microenvironment and poor target ability often reduce the therapeutic effect. Here we propose a tumor targeted nanoplatform PCN‐224@Co3O4‐HA for enhanced PDT and synergistic CDT, constructed by hyaluronate‐modified Co3O4 nanoparticles decorated metal‐organic framework PCN‐224. Co3O4 can catalyze the decomposition of highly expressed H2O2 in tumor cells to produce oxygen and alleviate the problem of hypoxia. It can also produce hydroxyl radicals according to the Fenton‐like reaction for chemical dynamic therapy, significantly improving the therapeutic effect. The cell survival experiment showed that after in vitro treatment, 4T1 and MCF‐7 cancer cells died in a large area under the anaerobic state, while the survival ability of normal cell LO2 was nearly unchanged. This result effectively indicated that PCN‐224@Co3O4‐HA could effectively relieve tumor hypoxia and improve the effect of PDT and synergistic CDT. Cell uptake experiments showed that PCN‐224@Co3O4‐HA had good targeting properties and could effectively aggregate in tumor cells. In vivo experiments on mice, PCN‐224@Co3O4‐HA presented reliable biosafety performance, and can cooperate with PDT and CDT therapy to prevent the growth of tumor.

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Section: Introductionmentioning

confidence: 99%

Metal‐Organic Framework PCN‐224 Combined Cobalt Oxide Nanoparticles for Hypoxia Relief and Synergistic Photodynamic/Chemodynamic Therapy

Yuan,

Chen,

Geng

et al. 2024

Chemistry A European J

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“…The conventional piezoelectric materials encompass wurtzite, 46 perovskite, 47 two-dimensional layered materials, 48 metal organic frameworks, 49,50 and bismuth-based materials. 51 Layered bismuth-based materials have the advantages of diversity, cost-effectiveness, high stability and a narrow band gap.…”

Section: Introductionmentioning

confidence: 99%

Facile synthesis of an α-Bi₂O₃/BiO₂ heterojunction for enhanced piezoelectric catalytic degradation of dye wastewater

Hou,

Tang,

Jiang

et al. 2024

New J. Chem.

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Piezoelectric Energy Harvesting: From Fundamentals to Advanced Applications

Bhatnagar,

Yadav,

Kumar

et al. 2024

Energy Tech

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Piezoelectric energy harvesting (PEH) has surfaced as an innovative technology for supplying power to low‐power electronic devices by converting mechanical energy into electrical energy. This technology utilizes the piezoelectric effect, in which specific materials produce an electric charge when they experience mechanical stress. Piezoelectric materials can be categorized into three main types: single crystal, composite, and polymeric. Single‐crystal materials exhibit elevated piezoelectric coefficients and stability; however, they tend to be costly and fragile. Composite materials integrate piezoelectric ceramics with polymer matrices, enhancing flexibility and lowering costs. Polymeric materials exhibit lightweight, flexible, and biocompatibility characteristics, rendering them ideal for wearable and implantable applications. Although PEH presents considerable promise, it is essential to tackle challenges, including low power output, material constraints, and environmental influences. Future investigations will focus on creating innovative materials that exhibit improved piezoelectric characteristics, refining device architecture for optimal energy conversion, and incorporating piezoelectric harvesting technology into intelligent systems. By addressing these challenges and investigating creative solutions, PEH can significantly advance sustainable and self‐powered electronic devices.

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A metal–organic framework-integrated composite for piezocatalysis-assisted tumour therapy: design, related mechanisms, and recent advances

Abstract: With the increasing demand for tumour treatment effectiveness, piezocatalytic therapy has become a promising method for cancer treatment because of its unique capacities of stress-induced ROS generation and regulating the...

Cited by 4 publications

References 81 publications

Metal‐Organic Framework PCN‐224 Combined Cobalt Oxide Nanoparticles for Hypoxia Relief and Synergistic Photodynamic/Chemodynamic Therapy

Metal‐Organic Framework PCN‐224 Combined Cobalt Oxide Nanoparticles for Hypoxia Relief and Synergistic Photodynamic/Chemodynamic Therapy

Facile synthesis of an α-Bi₂O₃/BiO₂ heterojunction for enhanced piezoelectric catalytic degradation of dye wastewater

Piezoelectric Energy Harvesting: From Fundamentals to Advanced Applications

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A metal–organic framework-integrated composite for piezocatalysis-assisted tumour therapy: design, related mechanisms, and recent advances

Abstract: With the increasing demand for tumour treatment effectiveness, piezocatalytic therapy has become a promising method for cancer treatment because of its unique capacities of stress-induced ROS generation and regulating the...

Cited by 4 publications

References 81 publications

Metal‐Organic Framework PCN‐224 Combined Cobalt Oxide Nanoparticles for Hypoxia Relief and Synergistic Photodynamic/Chemodynamic Therapy

Metal‐Organic Framework PCN‐224 Combined Cobalt Oxide Nanoparticles for Hypoxia Relief and Synergistic Photodynamic/Chemodynamic Therapy

Facile synthesis of an α-Bi2O3/BiO2 heterojunction for enhanced piezoelectric catalytic degradation of dye wastewater

Piezoelectric Energy Harvesting: From Fundamentals to Advanced Applications

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Facile synthesis of an α-Bi₂O₃/BiO₂ heterojunction for enhanced piezoelectric catalytic degradation of dye wastewater