The article discusses the experience of effective application of computer technologies, trainers and simulators in the system of training specialists for the nuclear industry at ISPU. The necessity and relevance of using computer-based learning tools in the educational process is determined. The main stages of training specialists and the concept of multi-level training based on the wide use of computer technologies developed at ISPU are considered. The main advantages and features of using automated training systems, local computer simulators, functional analytical simulator, full-scale simulator, simulation tools, simulator of the basic principles of NPP operation, as well as packages of numerical and analytical methods of mathematical modeling in the educational process are shown. The directions for further improvement of the educational process at ISPU in order to increase the level of training of young personnel for the nuclear industry are shown.