A method for determining glyphosate and its metabolite aminomethyl phosphonic acid by gas chromatography-flame photometric detection

Zhang, Weidong; Feng, Yanru; Ma, Li; An, Jing; Zhang, Hua-Yin; Cao, Mengsi; Huaijiao, Zhu; Kang, Weijun; Lian, Kaoqi

doi:10.1016/j.chroma.2018.12.039

Cited by 41 publications

(9 citation statements)

References 44 publications

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“…So, the much simpler and historically widely used HPLC–fluorimetry (HPLC-FLD) [ 98 , 99 , 100 , 101 ] or HPLC-UV [ 39 , 42 , 85 ] would be still suitable for the aim, in fact the limit of quantitation of these techniques is about 0.5 mg kg −1 [ 98 ]. Similar considerations apply to gas chromatography with nitrogen phosphorus (NPD) or a flame photometric detector (FPD), which are less specific detectors than mass spectrometers but of higher affordability and of good sensitivity [ 51 , 102 ]. However, for research work in complex matrices, more performing techniques are preferred.…”

Section: Chemical Analytical Methodsmentioning

confidence: 99%

Chromatographic Methods for the Determination of Glyphosate in Cereals Together with a Discussion of Its Occurrence, Accumulation, Fate, Degradation, and Regulatory Status

Masci,

Caproni,

Nevigato

2024

MPs

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The European Union’s recent decision to renew the authorization for the use of glyphosate until 15 December 2033 has stimulated scientific discussion all around the world regarding its toxicity or otherwise for humans. Glyphosate is a chemical of which millions of tons have been used in the last 50 years worldwide to dry out weeds in cultivated fields and greenhouses and on roadsides. Concern has been raised in many areas about its possible presence in the food chain and its consequent adverse effects on health. Both aspects that argue in favor of toxicity and those that instead may indicate limited toxicity of glyphosate are discussed here. The widespread debate that has been generated requires further investigations and field measurements to understand glyphosate’s fate once dispersed in the environment and its concentration in the food chain. Hence, there is a need for validated analytical methods that are available to analysts in the field. In the present review, methods for the analytical determination of glyphosate and its main metabolite, AMPA, are discussed, with a specific focus on chromatographic techniques applied to cereal products. The experimental procedures are explained in detail, including the cleanup, derivatization, and instrumental conditions, to give the laboratories involved enough information to proceed with the implementation of this line of analysis. The prevalent chromatographic methods used are LC-MS/MS, GC-MS/SIM, and GC-MS/MS, but sufficient indications are also given to those laboratories that wish to use the better performing high-resolution MS or the simpler HPLC-FLD, HPLC-UV, GC-NPD, and GC-FPD techniques for screening purposes. The concentrations of glyphosate from the literature measured in wheat, corn, barley, rye, oats, soybean, and cereal-based foods are reported, together with its regulatory status in various parts of the world and its accumulation mechanism. As for its accumulation in cereals, the available data show that glyphosate tends to accumulate more in wholemeal flours than in refined ones, that its concentration in the product strictly depends on the treatment period (the closer it is to the time of harvesting, the higher the concentration), and that in cold climates, the herbicide tends to persist in the soil for a long time.

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Section: Chemical Analytical Methodsmentioning

confidence: 99%

Chromatographic Methods for the Determination of Glyphosate in Cereals Together with a Discussion of Its Occurrence, Accumulation, Fate, Degradation, and Regulatory Status

Masci,

Caproni,

Nevigato

2024

MPs

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“…A 2019 study on GLY and AMPA analysis in soil showed that still GC-FPD can function as an adequate tool for such demanding analyses [89]. This research was intrigued by the obstacles observed in derivatization in connection with the by-product interferences in high-performance liquid chromatography (HPLC) analysis (when MS/MS mode is not utilized), which lead to inferior selectivity.…”

Section: Gc-fpdmentioning

confidence: 99%

Glyphosate Residues in Soil and Air: An Integrated Review

Tzanetou¹,

Karasali²

2020

Pests, Weeds and Diseases in Agricultural Crop and Animal Husbandry Production

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Glyphosate [N-(phosphonomethyl) glycine] (GPS) is currently the most commonly applied herbicide worldwide. Given the widespread use of glyphosate, the investigation of the relationship between glyphosate and soil ecosystem is critical and has great significance for its valid application and environmental safety evaluation. However, although the occurrence of glyphosate residues in surface and groundwater is rather well documented, only few information are available for soils and even fewer for air. Due to this, the importance of developing methods that are effective and fast to determine and quantify glyphosate and its major degradation product, aminomethylphosphonic acid (AMPA), is emphasized. Based on its structure, the determination of this pesticide using a simple analytical method remains a challenge, a fact known as the "glyphosate paradox." In this chapter a critical review of the existing literature and data comparison studies regarding the occurrence and the development of analytical methods for the determination of pesticide glyphosate in soil and air is performed.

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“…Among them, liquid chromatography–tandem mass spectrometry (LC–MS/MS) is the most commonly used for its accuracy and low limit of detection [ 7 ]. Chromatographic methods are also suitable for AMPA detection [ 8 , 9 ]. However, chromatography is costly and time-consuming.…”

Section: Introductionmentioning

confidence: 99%

Surface Plasmon Resonance Imaging Sensor for Detection of Photolytically and Photocatalytically Degraded Glyphosate

Vráblová

Smutná

Koutník

et al. 2022

Sensors

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Glyphosate is one of the most widely used pesticides, which, together with its primary metabolite aminomethylphosphonic acid, remains present in the environment. Many technologies have been developed to reduce glyphosate amounts in water. Among them, heterogeneous photocatalysis with titanium dioxide as a commonly used photocatalyst achieves high removal efficiency. Nevertheless, glyphosate is often converted to organic intermediates during its degradation. The detection of degraded glyphosate and emerging products is, therefore, an important element of research in terms of disposal methods. Attention is being paid to new sensors enabling the fast detection of glyphosate and its degradation products, which would allow the monitoring of its removal process in real time. The surface plasmon resonance imaging (SPRi) method is a promising technique for sensing emerging pollutants in water. The aim of this work was to design, create, and test an SPRi biosensor suitable for the detection of glyphosate during photolytic and photocatalytic experiments focused on its degradation. Cytochrome P450 and TiO2 were selected as the detection molecules. We developed a sensor for the detection of the target molecules with a low molecular weight for monitoring the process of glyphosate degradation, which could be applied in a flow-through arrangement and thus detect changes taking place in real-time. We believe that SPRi sensing could be widely used in the study of xenobiotic removal from surface water or wastewater.

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A method for determining glyphosate and its metabolite aminomethyl phosphonic acid by gas chromatography-flame photometric detection

Cited by 41 publications

References 44 publications

Chromatographic Methods for the Determination of Glyphosate in Cereals Together with a Discussion of Its Occurrence, Accumulation, Fate, Degradation, and Regulatory Status

Chromatographic Methods for the Determination of Glyphosate in Cereals Together with a Discussion of Its Occurrence, Accumulation, Fate, Degradation, and Regulatory Status

Glyphosate Residues in Soil and Air: An Integrated Review

Surface Plasmon Resonance Imaging Sensor for Detection of Photolytically and Photocatalytically Degraded Glyphosate

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