Wellbore stability studies are essential to guarantee the success during drilling oil and gas wells. This case study shows a Post Morten analysis of a horizontal well successfully drilled along a depleted reservoir, but with a narrow mud weight window, after a lost circulation during the cementation of the previous casing. The main goal is to show that even having a well-established general methodology for wellbore stability analysis, specific challenges may require different solutions to calibrate the mud weight window with field evidences. Challenges faced during drilling this wellbore were: (i) the wellbore was drilled after a lost circulation during cementing the previous phase. (ii) the existence of a narrow mud weight window, conditioned by unconsolidated sands with low resistance parameters, in the reservoir; (iii) the well path implies a critical combination of stresses around wellbore wall; (iv) the presence of a depleted reservoir. The in-situ stress prediction of horizontal stresses involved different criteria and showed a strong difference between the overburden and the reservoir. Minifrac tests, carried out in many wells along the field, present a considerable variation along the reservoir, suggesting some in-situ stress variation throughout the field. The analysis imposed a series of iterations by a carefully guided calibration of the input parameters and failure criteria. The analysis allowed calibrating and explaining field evidences, including the losses during cementing.