2022
DOI: 10.3389/fgene.2022.836841
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A microRNA Transcriptome-wide Association Study of Prostate Cancer Risk

Abstract: Large genome-wide association studies have identified hundreds of single-nucleotide polymorphisms associated with increased risk of prostate cancer (PrCa), and many of these risk loci is presumed to confer regulatory effects on gene expression. While eQTL studies of long RNAs has yielded many potential risk genes, the relationship between PrCa risk genetics and microRNA expression dysregulation is understudied. We performed an microRNA transcriptome-wide association study of PrCa risk using small RNA sequencin… Show more

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Cited by 3 publications
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“…Besides mRNAs, microRNAs (miRNAs) are commonly dysregulated in human cancers and play a critical role in the regulation of various genes [66][67][68][69][70][71][72]. MiRNAs are abundantly secreted through exosomes and can effectively mediate communication between cancer cells and normal cells, thereby contributing to cancer progression and metastasis [73,74].…”
Section: Transcriptomics and 3-d In Vitro Tumor Modelsmentioning
confidence: 99%
“…Besides mRNAs, microRNAs (miRNAs) are commonly dysregulated in human cancers and play a critical role in the regulation of various genes [66][67][68][69][70][71][72]. MiRNAs are abundantly secreted through exosomes and can effectively mediate communication between cancer cells and normal cells, thereby contributing to cancer progression and metastasis [73,74].…”
Section: Transcriptomics and 3-d In Vitro Tumor Modelsmentioning
confidence: 99%