A midbrain-reticulotegmental circuit underlies exaggerated startle under fear emotions

Guo, Weiwei; Fan, Sijia; Xiao, Dan; Guan, Mengyuan; Xiong, Wei

doi:10.1038/s41380-022-01782-6

Cited by 4 publications

(2 citation statements)

References 45 publications

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“…In this process, the increase in the activity of somatostatin (SST)-positive interneurons (INs) inhibits parvalbumin-positive (PV+) INs, which causes disinhibition of the principal cells of the dorsomedial prefrontal cortex [59]. Similarly, an exaggerated response to fear is mediated by a disinhibitory circuit involving the dorsal raphe nucleus, pericentral reticulotegmental nucleus, and central reticulotegmental nucleus [60].…”

Section: Disinhibitionmentioning

confidence: 99%

Disinhibition Is an Essential Network Motif Coordinated by GABA Levels and GABA B Receptors

Villalobos

2024

IJMS

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Network dynamics are crucial for action and sensation. Changes in synaptic physiology lead to the reorganization of local microcircuits. Consequently, the functional state of the network impacts the output signal depending on the firing patterns of its units. Networks exhibit steady states in which neurons show various activities, producing many networks with diverse properties. Transitions between network states determine the output signal generated and its functional results. The temporal dynamics of excitation/inhibition allow a shift between states in an operational network. Therefore, a process capable of modulating the dynamics of excitation/inhibition may be functionally important. This process is known as disinhibition. In this review, we describe the effect of GABA levels and GABAB receptors on tonic inhibition, which causes changes (due to disinhibition) in network dynamics, leading to synchronous functional oscillations.

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Section: Disinhibitionmentioning

confidence: 99%

Disinhibition Is an Essential Network Motif Coordinated by GABA Levels and GABA B Receptors

Villalobos

2024

IJMS

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“…The dorsal raphe nucleus (DRN) is located in the midbrain and plays a crucial role in diverse functions and brain states, including anxiety [ 9 ], post-traumatic stress disorder [ 10 , 11 ], depression [ 12 , 13 ], sleep [ 14 , 15 ], and social behaviors [ 16 , 17 ]. Predominantly consisting of serotoninergic (5-HT) neurons, the DRN also comprises other neuron types, including dopaminergic, GABAergic (gamma-aminobutyric acid), glutamatergic, and peptidergic neurons [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

High frequency deep brain stimulation of the dorsal raphe nucleus prevents methamphetamine priming-induced reinstatement of drug seeking in rats

Zhang,

Meng,

Huang

et al. 2024

Transl Psychiatry

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Drug addiction represents a multifaceted and recurrent brain disorder that possesses the capability to create persistent and ineradicable pathological memory. Deep brain stimulation (DBS) has shown a therapeutic potential for neuropsychological disorders, while the precise stimulation targets and therapeutic parameters for addiction remain deficient. Among the crucial brain regions implicated in drug addiction, the dorsal raphe nucleus (DRN) has been found to exert an essential role in the manifestation of addiction memory. Thus, we investigated the effects of DRN DBS in the treatment of addiction and whether it might produce side effects by a series of behavioral assessments, including methamphetamine priming-induced reinstatement of drug seeking behaviors, food-induced conditioned place preference (CPP), open field test and elevated plus-maze test, and examined brain activity and connectivity after DBS of DRN. We found that high-frequency DBS of the DRN significantly lowered the CPP scores and the number of active-nosepokes in the methamphetamine-primed CPP test and the self-administration model. Moreover, both high-frequency and sham DBS group rats were able to establish significant food-induced place preference, and no significant difference was observed in the open field test and in the elevated plus-maze test between the two groups. Immunofluorescence staining and functional magnetic resonance imaging revealed that high-frequency DBS of the DRN could alter the activity and functional connectivity of brain regions related to addiction. These results indicate that high-frequency DBS of the DRN effectively inhibits methamphetamine priming-induced relapse and seeking behaviors in rats and provides a new target for the treatment of drug addiction.

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Similarities and differences between post-traumatic stress disorder and major depressive disorder: Evidence from task-evoked functional magnetic resonance imaging meta-analysis

Wang,

He,

Yang

et al. 2024

Journal of Affective Disorders

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A midbrain-reticulotegmental circuit underlies exaggerated startle under fear emotions

Cited by 4 publications

References 45 publications

Disinhibition Is an Essential Network Motif Coordinated by GABA Levels and GABA B Receptors

Disinhibition Is an Essential Network Motif Coordinated by GABA Levels and GABA B Receptors

High frequency deep brain stimulation of the dorsal raphe nucleus prevents methamphetamine priming-induced reinstatement of drug seeking in rats

Similarities and differences between post-traumatic stress disorder and major depressive disorder: Evidence from task-evoked functional magnetic resonance imaging meta-analysis

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