A Mini Review on Recent Advancements in the Therapeutic Potentials of Benzothiazoles

Abstract

: Among the various fused heterocyclic rings, benzothiazole and its analogues have been explored broadly in search of newer therapeutic medicinal agents. The benzothiazole scaffold has been associated with huge biological potential like anticancer, antidiabetic, anti-inflammatory, anti-tubercular, antiviral, anti-convulsant etc. The occurrence of benzothiazole core in various compounds proves its value in the sphere of pharmaceutical chemistry. The connected research and developments in benzothiazole based chemistry become an active topic for medicinal scientists. A large number of benzothiazole and its heterocyclic derivatives are available in the market and used for the treatment of as clinical drugs have been extensively used in practice to treat diverse types of ailments with high therapeutic potential. This review presents the latest therapeutic developments of benzothiazole containing compounds in the medicinal chemistry.

Synthesis of Pyrazoline‐Embedded 1,2,3‐Triazole Derivatives via 1,3‐Dipolar Cycloaddition Reactions with in vitro and in silico Studies

“…Pyrazolines, a privileged class of five membered heterocyclic ring having two electron rich nitrogen atoms and a double bond and its derivatives are considered as a versatile molecules having various pharmacological acivities such as antifungal, [8] anti-inflammatory, [9] antibacterial, [10][11][12] anticonvulsant, [13] antipyretics, [14] analgesics, [15] antiamoebic [16] activities.…”

Solid‐Supported Materials‐Based Synthesis of 2‐Substituted Benzothiazoles: Recent Developments and Sanguine Future

“…Owing to the huge pharmacological significance associated with benzothiazole motif, several review articles were written on their synthetic methodologies and therapeutic potential [90–181] . We searched across various Web Engines such as SciFinder, Google Scholar, ScienceDirect and Pubmed with the keywords solid‐supported/Heterogeneous synthesis of benzothiazoles.…”

“…There were numerous review articles published in the literature encompassing the synthetic methodologies and pharmacological potential of benzothiazole scaffolds. Keri et al., [90] Choudhary et al., [91] Ali and Siddiqui, [92] Hisamoddin et al., [93] Jena, [94] Srivastava et al., [95] Gagoria et al., [96] Kamal et al., [97] Gjorgjieva et al., [98] Singh and Singh, [99] Pathak et al., [100] Sharma et al., [101] Rouf and Tanyeli, [102] Sompalle and Roopan, [103] Raju et al., [104] Tariq et al., [105] Abrol et al., [106] Irfan et al., [107] Temiz et al., [108] Wu et al., [109] Bhutani et al., [110] Bhat et al., [111] Sharma et al., [112] Bainsal et al., [113] Gupta et al., [114] Elamin et al., [115] Rana et al., [116] Firdaus et al., [117] Ammazzalorso et al., [118] Mohammad et al., [119] Satyadev et al., [120] Sumit et al., [121] Rouf et al., [102] Agarwal et al., [122] Kumar et al., [123] Asiri et al., [124] Amir et al., [125] Malik et al., [126] Agarwal et al., [127] and Azam et al [128] . published review articles on the developments of benzothiazole‐based scaffolds of pharmacological importance.…”

Synthesis, Characterization and Cytotoxicity Activity Study of Some Indole Derivatives

“…Pyrazolines are heterocyclic compounds with a five-membered unsaturated ring structure made up of two nitrogen atoms at positions 1 and 2 and three carbon atoms.A growing area in heterocyclic chemistry was the synthesis and Characteriztion of pyrazoline derivatives.This is because the pyrazoline ring attracted the attention of organic chemists due to their wide range of medicinal applications and very straightforward synthesis process] 5,6[.The derivatives of pyrozoline nucleus are known they possess antitumor, antibacterial, antifungal, antiviral, ant parasitic, antitubercular and insecticidal agents. Some of these compounds have also antiinflammatory, antidiabetic, anaesthetic and analgesic [7]. Pyrazolines remain privileged…”