A Minimally Invasive Flexible Micro-Needle Array as Continuous in vivo Electrochemical Glucose Sensor

Mou, Qun; Li, Junshi; Zheng, Fengyi; Cui, Yue; Jin, Yufeng; Li, Zhihong

doi:10.1109/nanomed49242.2019.9130616

Cited by 1 publication

(1 citation statement)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The device showed excellent sensing performance with a wide linear range, low detection limit and rapid response time for three metabolites (figure 16(b)). Our group has also proposed a microneedle device based on PI for glucose detection by fixing glucose oxidase on the surface [57]. Dardano et al [70] reported a multianalyte biosensor patch based on swellable microneedles for detecting glucose and lactic acid, through mixing corresponding oxidase enzymes in PEGDA microneedles.…”

Section: Sampling and Biosensingmentioning

confidence: 99%

Recent advances on fabrication of microneedles on the flexible substrate

Huang

et al. 2021

J. Micromech. Microeng.

View full text Add to dashboard Cite

Microneedles are able to penetrate into the skin and offer great chances in various biomedical applications including transdermal drug delivery, stable bio-signal monitoring, sampling and bio-sensing. Owing to the micro-scale feature size, microneedles have advantages of minimal invasiveness, pain, high biosafety and simple operation. However, it is still challenging to fabricate solid microneedles on a flexible substrate. This review primarily introduces recent studies about microneedles on the flexible substrate, various fabrication methods of microneedles on the flexible substrate, including micromolding, silicon dry/wet etching, electrochemical etching, drawing-lithography, electro-drawing lithography, magnetorheological drawing lithography, three-dimensional printing, vapor–liquid–solid grown, hot embossing, and assembly, and corresponding materials have been summarized and discussed in details. In the end, regular biomedical applications of microneedle on the flexible substrate are categorized into drug delivery, vaccine delivery, electrophysiological interaction, sampling and bio-sensing. Recent advances of each application have been discussed.

show abstract

Section: Sampling and Biosensingmentioning

confidence: 99%

Recent advances on fabrication of microneedles on the flexible substrate

Huang

et al. 2021

J. Micromech. Microeng.

View full text Add to dashboard Cite

show abstract

A Minimally Invasive Flexible Micro-Needle Array as Continuous in vivo Electrochemical Glucose Sensor

Cited by 1 publication

References 15 publications

Recent advances on fabrication of microneedles on the flexible substrate

Recent advances on fabrication of microneedles on the flexible substrate

Contact Info

Product

Resources

About