“…1,2 Calcium phosphosilicate putty (CPS putty) (NovaBone ORIGINAL RESEARCH 10.5005/jp-journals-10024-1832 JCDP Dental Putty; NovaBone Products, Alachua, FL), a commonly used alloplastic bone substitute, has been observed to have an osteostimulative effect in addition to osteoconductive properties and enhanced handling characteristics. 3,4 Several authors have proposed the addition of autologous growth factors such as plateletrich plasma (PRP) to be a safe measure to enhance the results of graft placement. 5,6 Platelet-rich plasma contains proinflammatory cytokines, growth factors, and other factors such as serotonin, histamine, dopamine, calcium, and adenosine, which have fundamental effects on the biologic aspects of wound healing.…”