A mixed antioxidant supplement improves cognitive function, and coordination in aged mice

Abstract

Accumulation of oxidative damage increases the risk of several disorders. To prevent these diseases, people consume supplements. However, there is little evidence of the impact of supplement intake on cognitive function. Recently, frailty and sarcopenia have become serious issues, and these phenomena include a risk of mild cognitive impairment. In this study, aged mice were fed the combination supplement and cognitive and motor functions were measured. Following 1 month of treatment with the supplement, significant improvements in cognitive function and neuromuscular coordination were observed. Following 2 weeks of treadmill training, treatment with the supplement dramatically increased running distance compared to that in untreated normal aged mice. Serum indices such as triglyceride and total cholesterol were significantly decreased in the supplement-treated aged mice compared to untreated aged mice. These results indicate that the combination supplement may play a role in maintaining cognitive function, coordination ability and improving lipid metabolism.

A Blended Vitamin Supplement Improves Spatial Cognitive and Short-Term Memory in Aged Mice

“…In this experiment, TwX, which has the same ingredients as commercially available Oxycut ® , was added to water consumed by aged mice to examine the effects of blended antioxidants. The composition ratios of the eight active ingredients contained in TwX [ 15 , 20 ] and the doses administered to mice are explained in detail in the method’s section. Some of the components contained in TwX exhibit anti-obesity effects when administered alone.…”

“…Blended supplements are one way to solve these problems [ 15 ]. As the dosage is determined in advance, consumers do not need to worry about overdosing.…”

Oxidative Stress and Bio-Regulation

“…Consequently, antioxidants are being explored for their potential in treating stroke, arteriosclerosis, and slowing down the aging process. One such example is the development of Twendee X, a nutritional supplement with potent levels of eight key antioxidants that is being considered for application in several ailments, such as ischemic stroke and early dementia [ 65 , 66 , 67 , 68 , 69 , 70 ].…”