A model for 532‐nanometer pulsed potassium titanyl phosphate (KTP) laser—Induced injury in the rat larynx

Abstract

We propose that this novel model simulates the clinical scenario of laser use for the vocal folds. Use of this model will allow us to further characterize effects, mechanisms, and therapeutic efficacy of this wavelength.

532‐nanometer potassium titanyl phosphate (KTP) laser‐induced expression of selective matrix metalloproteinases (MMP) in the rat larynx

“…Previously, we described a model for videoendoscopic visualization and KTP‐induced injury of the rat larynx 15. Our model revealed gross mucosal blanching without eschar, with 10W 20mS energy and pulse width, consistent with a clinical scenario of KTP laser treatment.…”

“…Endoscopic visualization and videoendoscopic KTP survival surgery was performed as previously described in our work 15. The Aura XP 532‐nm laser with Starpulse (American Medical Systems/Laserscope, Minnetonka, MN) was employed to deliver 532‐nm KTP laser at 10W 20mS energy.…”

Advances in office‐based diagnosis and treatment in laryngology

“…Despite its extensive clinical use, little basic research has been done to study the effects of this laser on the vocal fold. Amin and colleagues have recently created an animal model for studying its effects on rat vocal fold epithelium 64…”

Expression of tenascin‐C in a rat vocal fold injury model and its regulation of fibroblasts

“…In this study, vocal fold injury was modeled by epithelium and lamina propria stripping. This injury model may be one factor causing the transient expression pattern, and further investigations should be carried out in different models, such as the potassium titanyl phosphate laser injury model . These studies will provide more information on Tnc expression in vocal fold injury.…”