A Model for Regional Cerebral Oxygen Distribution During Continuous Inhalation of 15o2, C15o. And C15o2

Subramanyam, Rajeshwari; Alpert, Nathaniel M.; Hoop, B.; Brownell, G.L.; Taveras, Juan M.

doi:10.1097/00004728-197811000-00080

Cited by 37 publications

(50 citation statements)

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“…The steady-state method (Subramanyam et al, 1978;Lammertsma et al, 1982;Correia et al, 1985;Okazawa et al, 2001a, b) has been used in a number of studies in which quantitative images are estimated from data acquired while in the steady state reached during continuous inhalation of C 15 O 2 and 15 O 2 . This method can be used using a simple procedure and mathematical formula, but still has several limitations.…”

Section: Introductionmentioning

confidence: 99%

Rapid Quantitative Measurement of CMRO₂ and CBF by Dual Administration of ¹⁵O-Labeled Oxygen and Water During a Single PET Scan—a Validation Study and Error Analysis in Anesthetized Monkeys

Kudomi

Hayashi

Teramoto

et al. 2005

J Cereb Blood Flow Metab

101

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Cerebral blood flow (CBF) and rate of oxygen metabolism (CMRO 2 ) may be quantified using positron emission tomography (PET) with 15 O-tracers, but the conventional three-step technique requires a relatively long study period, attributed to the need for separate acquisition for each of 15 O 2 , H 2 15 O, and C 15 O tracers, which makes the multiple measurements at different physiologic conditions difficult. In this study, we present a novel, faster technique that provides a pixel-by-pixel calculation of CBF and CMRO 2 from a single PET acquisition with a sequential administration of 15 O 2 and H 2 15 O. Experiments were performed on six anesthetized monkeys to validate this technique. The global CBF, oxygen extraction fraction (OEF), and CMRO 2 obtained by the present technique at rest were not significantly different from those obtained with three-step method. The global OEF (gOEF) also agreed with that determined by simultaneous arterio-sinus blood sampling (gOEF AÀV ) for a physiologically wide range when changing the arterial PaCO 2 (gOEF ¼ 1.03gOEF AÀV þ 0.01, Po0.001). The regional values, as well as the image quality were identical between the present technique and three-step method for CBF, OEF, and CMRO 2 . In addition, a simulation study showed that error sensitivity of the present technique to delay or dispersion of the input function, and the error in the partition coefficient was equivalent to that observed for three-step method. Error sensitivity to cerebral blood volume (CBV) was also identical to that in the three-step and reasonably small, suggesting that a single CBV assessment is sufficient for repeated measures of CBF/CMRO 2 . These results show that this fast technique has an ability for accurate assessment of CBF/CMRO 2 and also allows multiple assessment at different physiologic conditions.

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Section: Introductionmentioning

confidence: 99%

Rapid Quantitative Measurement of CMRO₂ and CBF by Dual Administration of ¹⁵O-Labeled Oxygen and Water During a Single PET Scan—a Validation Study and Error Analysis in Anesthetized Monkeys

Kudomi

Hayashi

Teramoto

et al. 2005

J Cereb Blood Flow Metab

101

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“…Therefore, the activity was measured for a certain time interval in calculation of the cumulated activity in source organs, no experimental data of activity were present after the last measurement; the fitting parameters provided the organ activity for an infinite time with a constant biological disappearance data. 15,16 …”

Section: Discussionmentioning

confidence: 99%

“…9 The conventional techniques used in the purpose are the extrapolation of animal data to human, calculations based on the mathematical biokinetic models and direct measurements. [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] Among this method direct measurements can provide activity distributions with less biological assumption and NCRP (national council of radiation protection has emphasized on direct measurements of the radio activities distributed in human. 9 Single photon emission computed tomography (SPECT) and positron emission tomography (PET) is a new imaging modality in nuclear medicine that provides regional as well as global information about physiology or chemistry within various body organs.…”

Section: Introductionmentioning

confidence: 99%

Dissimilarity of absorbing internal radiation dose of 99mTc- diethylenetriaminepentacetate among male, female and international committee for radiation protection - 53 recommended data

Islam

Roy

2016

Int J Basic Clin Pharmacol

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“…The single compartment model has been used in PET for various measurement pro tocols, which include in vivo autoradiographic (Ginsberg et al, 1982;Herscovitch et al, 1983), steady-state (Subramanyam et al , 1978;Jones et al , 1976), and dynamic measurement techniques (Yamamoto et al, 1977;Kanno et al, 1979;Huang et al , 1983;Alpert et al, 1984). Most of these methods require the introduction of 150-water through inhalation of 150-C02 or direct intravenous injection.…”

Section: Discussionmentioning

confidence: 99%

A Study of the Single Compartment Tracer Kinetic Model for the Measurement of Local Cerebral Blood Flow Using ¹⁵O-Water and Positron Emission Tomography

Gambhir

Huang

Hawkins

et al. 1987

J Cereb Blood Flow Metab

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Summary:The effects of varying the data collection time on the calculation of cerebral blood flow and distribution volume via the integrated projection technique were studied in four human subjects. The significance of these results in terms of the limitations of the single compart ment model for 150-water was explored using computer simulations. The simulations helped to account for causes for the variations seen in blood flow and distribuOver the last few years, several general methods have emerged to quantitate local cerebral blood flow (lCBF) with the use of positron emission to mography (PET) (Frackowiak et al. , 1980; Huang et al. , 1982;Raichle et al. , 1983). Cerebral tissues de pend on ICBF for delivery of nutrients and for the removal of metabolic products, and therefore, quantitative measurement of ICBF provides an im portant way for assessing local brain function. Most methods currently being used with PET employ 150-water as the tracer and are based on a single compartment model for the calculation of ICBF. Recently, investigators have noticed that the ICBF estimate is a function of the total data collection time (Raichle et al., 1983). These observations raise questions about the adequacy of the single com partment model for describing the transport ki netics of 150-water in brain tissue (Huang et al., 1983). The present study addresses this important issue. 13tion volume as a function of the data collection time. Two different compartmental models were explored for better quantitation of blood flow and distribution volume.

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A Model for Regional Cerebral Oxygen Distribution During Continuous Inhalation of 15o2, C15o. And C15o2

Cited by 37 publications

References 0 publications

Rapid Quantitative Measurement of CMRO₂ and CBF by Dual Administration of ¹⁵O-Labeled Oxygen and Water During a Single PET Scan—a Validation Study and Error Analysis in Anesthetized Monkeys

Rapid Quantitative Measurement of CMRO₂ and CBF by Dual Administration of ¹⁵O-Labeled Oxygen and Water During a Single PET Scan—a Validation Study and Error Analysis in Anesthetized Monkeys

Dissimilarity of absorbing internal radiation dose of 99mTc- diethylenetriaminepentacetate among male, female and international committee for radiation protection - 53 recommended data

A Study of the Single Compartment Tracer Kinetic Model for the Measurement of Local Cerebral Blood Flow Using ¹⁵O-Water and Positron Emission Tomography

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A Model for Regional Cerebral Oxygen Distribution During Continuous Inhalation of 15o2, C15o. And C15o2

Cited by 37 publications

References 0 publications

Rapid Quantitative Measurement of CMRO2 and CBF by Dual Administration of 15O-Labeled Oxygen and Water During a Single PET Scan—a Validation Study and Error Analysis in Anesthetized Monkeys

Rapid Quantitative Measurement of CMRO2 and CBF by Dual Administration of 15O-Labeled Oxygen and Water During a Single PET Scan—a Validation Study and Error Analysis in Anesthetized Monkeys

Dissimilarity of absorbing internal radiation dose of 99mTc- diethylenetriaminepentacetate among male, female and international committee for radiation protection - 53 recommended data

A Study of the Single Compartment Tracer Kinetic Model for the Measurement of Local Cerebral Blood Flow Using 15O-Water and Positron Emission Tomography

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Rapid Quantitative Measurement of CMRO₂ and CBF by Dual Administration of ¹⁵O-Labeled Oxygen and Water During a Single PET Scan—a Validation Study and Error Analysis in Anesthetized Monkeys

Rapid Quantitative Measurement of CMRO₂ and CBF by Dual Administration of ¹⁵O-Labeled Oxygen and Water During a Single PET Scan—a Validation Study and Error Analysis in Anesthetized Monkeys

A Study of the Single Compartment Tracer Kinetic Model for the Measurement of Local Cerebral Blood Flow Using ¹⁵O-Water and Positron Emission Tomography