2013
DOI: 10.4161/cbt.25941
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A model of sensitivity and resistance to histone deacetylase inhibitors in diffuse large B cell lymphoma

Abstract: Diffuse large B cell lymphoma (DLBCL) is an aggressive form of non-Hodgkin lymphoma. While the initial treatment strategy is highly effective, relapse occurs in 40% of cases. Histone deacetylase inhibitors (HDACi) are a promising class of anti-cancer drugs but their single agent efficacy against relapsed DLBCL has been variable, ranging from few complete/partial responses to some stable disease. However, most patients showed no response to HDACi monotherapy for unknown reasons. Here we show that sensitivity an… Show more

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Cited by 22 publications
(42 citation statements)
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“…Although mitotic cells appear to accumulate in SUDHL4 and SUDHL8 cells in response to belinostat, these cell lines eventually arrest in G1. 15 It is possible that the increase in mitotic cells is due to a mitotic delay that is eventually resolved. We therefore examined high magnification images of the H3S10Ph-stained cells for evidence of anaphase mitotic figures, which would indicate that cells are progressing beyond prometaphase, when the spindle assembly checkpoint (SAC) is activated.…”
Section: Resultsmentioning
confidence: 99%
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“…Although mitotic cells appear to accumulate in SUDHL4 and SUDHL8 cells in response to belinostat, these cell lines eventually arrest in G1. 15 It is possible that the increase in mitotic cells is due to a mitotic delay that is eventually resolved. We therefore examined high magnification images of the H3S10Ph-stained cells for evidence of anaphase mitotic figures, which would indicate that cells are progressing beyond prometaphase, when the spindle assembly checkpoint (SAC) is activated.…”
Section: Resultsmentioning
confidence: 99%
“…15 One is characterized by a reversible arrest in the G1 phase of the cell cycle within 24-48 h of treatment without accompanying apoptosis. In contrast, the second response is characterized by G2/ M arrest within 24 h and subsequent onset of apoptosis by 48 hours.…”
Section: Resultsmentioning
confidence: 99%
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