The tire forces of vehicles will fall into the non-linear region under extreme handling conditions, which cause poor path tracking performance. In this paper, a model predictive controller based on a nonlinear tire model is designed. The tire forces are characterized with nonlinear composite functions of the magic formula instead of a simple linear relation model. Taylor expansion is used to linearize the controller, the first-order difference quotient method is used for discretization, and the partial derivative of the composite function is used for matrix transformation. Constant velocity and variable velocity conditions are selected to compare the designed controller with the conventional controller in Carsim/Simulink. The results show that when the tire forces fall in the nonlinear region, two controllers have good stability, and the tracking accuracy of the controller designed in this paper is slightly better. However, after the tire forces become nonlinear, the controller with linear tire force becomes worse, the tracking accuracy is far worse than the controller with the nonlinear tire model, and the vehicle stability is also degraded. In addition, an active steering test platform based on LabVIEW-RT is established, and hardware-in-the-loop tests are carried out. The effectiveness of the designed controller is verified.