A model program for hepatitis B vaccination and education of schoolchildren in rural China

Chen, Jonathan J.; Chang, Ellen T.; Chen, Yiren; Bailey, Meredith B.; So, Samuel

doi:10.1007/s00038-011-0289-x

Cited by 6 publications

(4 citation statements)

References 21 publications

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“…23 In agreement with such recommendations, Chinese health authorities conducted a national catch-up HBV vaccination program from 2009 to 2011. 39,40 . This program succeeded in increasing the coverage rates, which can also be observed in our results.…”

Section: Discussionmentioning

confidence: 99%

Hepatitis B vaccination among 1997-2011 birth cohorts in rural China: the potential for further catch-up vaccination and factors associated with infant coverage rates

Wangen

Zhu

Wang

2018

Human Vaccines & Immunotherapeutics

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Hepatitis B vaccination rates in China have recently increased. This study aimed to investigate infant vaccination coverage for birth cohorts from 1997 to 2011 in rural regions and to assess catch-up vaccination potential. We used questionnaire-based interviews from a cross-section of 6,529 individuals from seven provinces. Logistic regression analyses were used to model two measures of infant vaccination status, namely, birth dose within 24 hours and three doses within the first year of life. During interviews, individuals' vaccination status and vaccination plan were recorded. Unvaccinated individuals without plans for future vaccination were presented with a hypothetical offer of free vaccination and indirect cost compensation. Institutional birth rates were higher than vaccination rates, but both increased over time. Vaccination coverage rates were not significantly associated with sex. Infant vaccination coverage was positively associated with a mother's educational level, household income level, knowledge of transmission routes, and perceived duration of protection obtained through vaccination. Vaccination status at the time of the survey showed the occurrence of catch-up vaccinations, but a notable percentage of individuals remained unvaccinated and had no plans for future vaccination. Of these individuals, approximately 50% were prepared to accept vaccination if offered free of charge.

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Section: Discussionmentioning

confidence: 99%

Hepatitis B vaccination among 1997-2011 birth cohorts in rural China: the potential for further catch-up vaccination and factors associated with infant coverage rates

Wangen

Zhu

Wang

2018

Human Vaccines & Immunotherapeutics

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“…A study of HBV and liver cancer among the Asian population in the US concluded that increased health education and improved community-based interventions are necessary to prevent HBV-related liver disease in high-risk groups [ 23 ]. In China, where HBV is the primary cause of liver cancer, a total of 1925 students from 26 elementary schools were enrolled in an HBV education program; they achieved significant improvement of knowledge about the modes of transmission and protection against HBV [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Preventing hepatocellular carcinoma in Egypt: results of a Pilot Health Education Intervention Study

et al. 2015

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BackgroundHepatocellular carcinoma (HCC), one of the most fatal malignancies, is particularly prevalent in Egypt, where we previously found deficiencies in knowledge concerning HCC and its risk factors. Hepatitis B and C viral infections are highly prevalent in Egypt, pesticides are very commonly used, and diets are often contaminated by aflatoxin, especially in rural areas.MethodsWe conducted a study to pilot test a health education intervention addressing HCC, its risk factors, and its main modes of prevention. It included four health education modules: HCC, hepatitis viruses, pesticides and aflatoxin. We used a pre- and post-intervention set of questionnaires to assess knowledge gained by the participants.ResultsA total of 25 participants from a village in the Nile Delta area attended the health education session and completed the questionnaires. The education intervention significantly increased the participants’ knowledge on HCC and its risk factors, particularly regarding the use of pesticides at home and aflatoxin contaminated foods (both p < 0.05). Overall, there was a 12 % increase in the number of participants who believed that HCC could be prevented, and they reported their intention to practice prevention for HCC risk factors.ConclusionsWe found that the education intervention we pilot tested was feasible and proved effective in increasing participants’ knowledge. Future efforts should focus on implementing targeted education programs in high-risk populations in Egypt.

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“…Our study has several important limitations. First, we did not control for some important potential confounders such as access to health care, knowledge, attitude and practices of the providers and parents, and the socio‐economic status of the child's family . Second, the sample size used to evaluate impact of the policy was relatively small for each birth year, although the total sample size seems sufficient, which could lead to incorrect associations being reported.…”

Section: Discussionmentioning

confidence: 99%

Impact of the free‐vaccine policy on timely initiation and completion of hepatitis B vaccination in Fujian, China

Wu¹,

Wen

Yong³

et al. 2014

Journal of Viral Hepatitis

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The extent to which the free-vaccine policy impacts the initiation and completion of a hepatitis B vaccine series is poorly understood. The aim of this study was to evaluate the impact of the free-vaccine policy on hepatitis B vaccination. A provincial survey was conducted in 2006 in Fujian Province, south-east of China, where the free-vaccine policy for hepatitis B was announced in 2002 and implemented in 2003. A total of 1628 children were investigated, and 1443 (88.6%) were included in this analysis. Among the children studied, 55.2% were vaccinated within 24 h of birth, and 76.1% completed the hepatitis B vaccine series on time. The rate of hepatitis B surface antibody positivity increased from 29.9% among children born in 1992 to 90.5% among children born in 2005, while the corresponding HBV infection rate decreased from 30.4% to 1.72%. Logistic regression indicated that, compared to children born between 1996 and 2001, the odds ratios (ORs) for timely initiation were 2.57 (95% confidence interval [CI], 1.71-3.84), 5.24 (95% CI, 3.26-8.43) and 9.06 (95% CI, 4.48-18.34) among children born in 2003, 2004 and 2005, respectively; the corresponding ORs for completing the vaccine series were 4.23 (95% CI, 1.97-9.10), 3.76 (95% CI, 1.81-7.82) and 4.94 (95% CI, 1.74-14.00) among children born in 2003, 2004 and 2005, respectively. Children with delayed vaccine initiation (>24 h after birth) were less likely to complete the vaccine series than those who received a timely first dose (OR = 0.02, 95% CI, 0.005-0.09). The impact of the free-vaccine policy on vaccine initiation and vaccine series completion did not differ by children's residence area (rural vs urban). As hypothesized, the odds of completing the vaccine series increased after the free-vaccine policy was announced in 2002 among children with delayed initiation (>24 h after birth) but not among those with timely initiation (≤ 24 h after birth). In conclusion, the free-vaccine policy significantly improved the timely initiation and completion of the vaccine series. The impact of this policy on completion of the vaccine series was larger among children with delayed vaccine initiation.

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A model program for hepatitis B vaccination and education of schoolchildren in rural China

Abstract: This program offers an effective and sustainable model for HBV catch-up vaccination and education that can be replicated throughout China, as well as in other underserved HBV-endemic regions, as a strategy to reduce chronic HBV infection, liver failure, and liver cancer.

Cited by 6 publications

References 21 publications

Hepatitis B vaccination among 1997-2011 birth cohorts in rural China: the potential for further catch-up vaccination and factors associated with infant coverage rates

Hepatitis B vaccination among 1997-2011 birth cohorts in rural China: the potential for further catch-up vaccination and factors associated with infant coverage rates

Preventing hepatocellular carcinoma in Egypt: results of a Pilot Health Education Intervention Study

Impact of the free‐vaccine policy on timely initiation and completion of hepatitis B vaccination in Fujian, China

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