A Model to Integrate Patient Preferences Into Delivery systems: the Importance of end-user Input Into Pulmonary Delivery

Rockich‐Winston, Nicole; Gillette, Chris; Train, Brian; Tippens, Amber S.; Flesher, Susan; Shepherd, Meagan

doi:10.4155/tde-2016-0042

Cited by 1 publication

(1 citation statement)

References 15 publications

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“…and caregivers to give feedback in early research stage in the development of drug delivery systems for the elderly is beneficial and their feedback may be used to improve optimal drug delivery and clinical outcomes [468]. Mixing medications with food, a common practice in aged care settings, can also potentially affect drug absorption.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Challenges and innovations of drug delivery in older age

Khan

Roberts

2018

Advanced Drug Delivery Reviews

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Both drug delivery performance and various age-related physical, mental and physiological changes can affect drug effectiveness and safety in elderly patients. The many drug delivery systems developed over the years include recent novel transdermal, nasal, pulmonary and orally disintegrating tablets that provide consistent, precise, timely and more targeted drug delivery. Certain drug delivery systems may be associated with suboptimal outcomes in the elderly because of the nature of drug present, a lack of appreciation of the impact of age-related changes in drug absorption, distribution and clearance, the limited availability of pharmacokinetic, safety and clinical data. Polypharmacy, patient morbidity and poor adherence can also contribute to sub-optimal drug delivery systems outcomes in the elderly. The development of drug delivery systems for the elderly is a poorly realised opportunity, with each system having specific advantages and limitations. A key challenge is to provide the innovation that best meets the specific physiological, psychological and multiple drug requirements of individual elderly patients.

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Section: Accepted Manuscriptmentioning

confidence: 99%