A modern view on the complement system

Шахиджанов, С. С.; Филиппова, А. Е.; Butylin, Andrey A.; Ataullakhanov, F. I.

doi:10.24287/1726-1708-2019-18-3-130-144

Voprosy gematologii/onkologii i immunopatologii v pediatrii

2019

DOI: 10.24287/1726-1708-2019-18-3-130-144

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A modern view on the complement system

С. С. Шахиджанов

А. Е. Филиппова

Andrey A. Butylin

et al.

Abstract: Complement is a part of the immune system which provides host cells with protection against pathogen cells and particles. It is activated when a pathogen invasion is detected. The results of numerous investigations have led to growing realization of the important role of this system in maintaining normal organism homeostasis. This review summarizes a modern view on the complement system.

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Cited by 3 publications

References 133 publications

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Neuromyelitis optica spectrum disorders and complement system: issues of pathogenesis and therapeutic options

Krasnov

2023

RJTAO

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An important component of the pathogenesis of neuromyelitis optica spectrum diseases (NMOSD) with antibodies to aquaporin-4 (AQP4-IgG) is a classical pathway of complement system (CS) activation with the implementation of mechanisms of complement-mediated cytotoxicity. Eculizumab is a humanized monoclonal antibody that suppresses the final stage of CS activation and has a high affinity for its C5 component. The most important components in the pathogenesis of NMOSD with AQP4-IgG, the role of CS, the results of clinical trials with the drug eculizumab and its place in the treatment of NMOSD are discussed.

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Neuromyelitis optica spectrum disorders and complement system: issues of pathogenesis and therapeutic options

Krasnov

2023

RJTAO

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Features of the immune response in early period of ixodid tick-borne borreliosis

Samoylov,

Koval,

Ilyinskikh

et al. 2023

Epidemiology and Infectious Diseases

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Lyme borreliosis is a group of transmissible infectious diseases that are similar in etiology, but diverse in clinical manifestations. The development of Lyme disease symptoms is due not only to the activity of the pathogen itself, but also to the result of its interaction with immune system of macroorganism. The first line of defense, represented by a variety of cellular and humoral components of innate immunity, is most rapidly involved in immune response, and it is it that seeks to limit dissemination of the causative agent from the initial site of infection. However, a wide range of protective surface proteins of Borrelia and a number of other structures aimed at avoiding immune mechanisms prevent the destruction of the pathogen. Not the last place in this dynamic process is occupied by ixodid ticks themselves, since the secret of their salivary glands has an inhibitory effect on a number of cells and complement system. In parallel with innate immunity, adaptive immune response factors are activated, serving as a second line of defense. The synthesis of specific antibodies in the early period of Lyme disease has its own ambiguous features, but this does not exclude their importance in fight against borreliosis infection. To date, the issues of interaction with dendritic cells and cytotoxic T-lymphocytes remain less studied. Research of all aspects, including little-studied ones, is extremely important for both practical healthcare and fundamental medicine.

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Parameters of macrophage reaction and humoral immunity in patients with implant-associated in-flammation after primary endoprosthetics of knee joint

Galashina

Анатольевна²,

Гладкова

et al. 2020

I.P. Pavlov Russian Medical Biological Herald

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Aim. To study peculiarities of macrophage reaction and humoral immunity in patients with signs of implant-associated inflammation after the primary endoprosthetics of the knee joint. Materials and Methods. Examination of 48 patients with signs of implant-associated inflammation after the primary endoprosthetics of the knee joints (the main group) and of 44 patients without signs of inflammatory reactions (comparison group) was carried out. Control group involved 30 healthy donors without diseases of the musculoskeletal system. Results. In 1 and 12 months after the surgery, patients of the main group showed elevated levels of the factor inhibiting migration of macrophages (MIF), of macrophage stimulating protein (MSP), class A immunoglobulins (IgA), С3 and С4 complement components as compared to control, and also to each previous period. In 1 month after the surgery, the content of class M and G immunoglobulins (IgM and IgG) decreased relative to control; in 12 months after the surgery a more pronounced reduction was noted. Increase in serum concentrations of MIF, MSP, IgA, С3 and С4-complement components was noted in the comparison group in 1 and 12 months and also in comparison with the previous period. Reduction of the levels of IgM, IgG in 1 and 12 months after the operation was noted in comparison with control and with the previous period. Conclusion. A study of parameters of macrophage reaction, proteins of complement system and the main classes of immunoglobulins permits to identify signs of implant-associated inflammation in 1 and 12 months after surgery, and, consequently, to determine patients of risk groups that require additional diagnostics measures.

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A modern view on the complement system

Cited by 3 publications

References 133 publications

Neuromyelitis optica spectrum disorders and complement system: issues of pathogenesis and therapeutic options

Neuromyelitis optica spectrum disorders and complement system: issues of pathogenesis and therapeutic options

Features of the immune response in early period of ixodid tick-borne borreliosis

Parameters of macrophage reaction and humoral immunity in patients with implant-associated in-flammation after primary endoprosthetics of knee joint

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