A Modified Hyaluronic Acid–Based Dissolving Microneedle Loaded With Daphnetin Improved the Treatment of Psoriasis

Abstract

Psoriasis is a common chronic immune-inflammatory disease. Challenges exist in the present treatment of psoriasis, such as difficulties in transdermal drug administration and severe side effects. We hope to achieve a better therapeutic outcome for psoriasis treatment. By using modified soluble microneedles (MNs) loaded with daphnetin, the psoriasis symptoms of mice, the abnormal proliferation of keratinocytes, and the secretion of inflammatory factors were significantly reduced. In vitro, daphnetin is proven to inhibit the NF-κB signaling pathway and to inhibit the proliferation of HaCaT cells and the release of inflammatory factors, especially CCL20. This research showed that the modified microneedle loaded with daphnetin optimized transdermal drug delivery and relieved the symptoms of psoriasis more effectively. The novel route of Daph administration provides a future research direction for the treatment of psoriasis.

Natural Compounds and Biomimetic Engineering to Influence Fibroblast Behavior in Wound Healing

“…Indeed, the journey of topical compounds to penetrate the wound site is limited by several physiological barriers, and passive drug diffusion into the skin is generally impeded by the outermost lipophilic layer of the skin, the stratum corneum. This tight layer is composed of lipids including triglycerides, cholesterol, and free fatty acids that are linked by covalent bonds with corneocytes and provide a defensive barrier to the external environment [ 127 ].…”

Advances in pathogenesis and nanoparticles (NPs)-mediated treatment of psoriasis

“…unique advantages, microneedles have been widely used as effective transdermal drug delivery tools for the treatment of skin diseases including psoriasis (90,91,94). Du et al developed a microneedle patch made with hyaluronic acid (HA) and encapsulated MTX into the patch, which could effectively penetrate the IMQ-induced mouse epidermis and impair psoriasis-like skin inflammation in mice (95).…”

“…Microneedles is a type of new drug delivery systems developed in recent years, which can significantly improve the permeability and increase the bioavailability of therapeutic agents by piercing the stratum corneum and creating a large number of reversible microchannels in a minimally invasive manner. Due to these unique advantages, microneedles have been widely used as effective transdermal drug delivery tools for the treatment of skin diseases including psoriasis ( 90 , 91 , 94 ). Du et al.…”

Microneedle-Mediated Transdermal Delivery of Biopharmaceuticals

“…An enhancement in transdermal and intradermal drug delivery could be achieved using a variety of strategies, including penetration enhancers, innovative formulation designs, and physical techniques [ 26 ]. Recently, microneedles have emerged as the most effective and reliable method for transdermal drug delivery, as recommended by multiple research works in academic institutions and industrial companies [ 4 , 27 , 28 , 29 ].…”

“…Commonly used polymers include SU-8 photoresist, cyclic-olefin copolymer, polycarbonate, poly (methylmetha-acrylate), poly-lactic-co-glycolic acid (PLGA), poly-glycolic acid, polystyrene, polylactic acid, poly (vinyl pyrrolidone), polyvinyl alcohol, and sodium carboxy methyl cellulose. PLGA, chitosan, and hyaluronic acid were the most frequently used in microneedle fabrication [ 26 , 51 , 52 ]. Several research groups have recently evaluated various materials (i.e., natural, synthetic, semisynthetic polymers, and particle composites) for microneedle fabrication [ 53 , 54 , 55 ].…”