A Molecular-Recognition Microcapsule for Environmental Stimuli-Responsive Controlled Release

Abstract

Unique molecular‐recognition microcapsules for environmental stimuli‐responsive controlled release have been developed. The microcapsules consist of a core–shell porous membrane. The pores contain linear‐grafted poly(NIPAM‐co‐BCAm) chains, which act as the molecular‐recognition gates. The Figure shows the mechanism of the opening of the pores to release the molecules inside.

A Novel Route to Thermosensitive Polymeric Core-Shell Aggregates and Hollow Spheres in Aqueous Media

“…In addition, methods such as layer-by-layer deposition on colloidal particle templates [15±20] and emulsion polymerization [21±24] have been developed for this purpose. Furthermore, in order to enable the transport and delivery of guest molecules under particularly demanding conditions, ªintelligentº micelles and hollow spheres, which are sensitive to temperature, [18,24±27] pH, [2,12,13,19,28±32] ions, [19,33] and ionic strength, [17,34] have also been reported. Among the polymer materials employed for such assemblies, poly(N-isopropylacrylamide) (PNIPAM) has been extensively studied owing to its thermosensitive phase transition at the lower critical solution temperature (LCST) around 32 C. [35,36] In a significant development of our long-term research on self-assembly following our ªblock-copolymer-freeº strategies, [37±42] herein we report a novel route to thermosensitive core±shell aggregates and hollow spheres, as well as their environment-sensitive properties.…”

Synthesis and Investigation of a Novel pH- and Salt-Responsive Superabsorbent Hydrogel Based on Pectin

“…They are widely used in various applications such as hygienic, foods, cosmetics, and agriculture 1 . This accounts for increase in the worldwide production of superabsorbent polymers (SAPs) from 6000 tons in 1983 to 450000 tons in 1996 [2][3][4] . Nowadays, the worldwide production of SAPs is more than one million tons in year.…”

“…Nowadays, the worldwide production of SAPs is more than one million tons in year. Hence, synthesis and characterization of superabsorbent hydrogels is the main goal of the several research groups in the world [3][4][5][6][7] .…”

Firstborn microcrystallization method to prepare nanocapsules containing artesunate

“…Their characteristics are larger inner volume and much higher interfacial area per unit mass of macro-or nanoparticles, which help carry more drug and having much greater exchange rates. 6 Furthermore, microencapsulation of drugs can reduce its toxic side effects and improve its stability. Especially for intravenous injection, the nanocapsules with drugs can pass the smallest capillaries in the body without blockage.…”