A molecular recognition platform for the simultaneous sensing of diverse chemical weapons

Zeng, Lintao; Chen, Tianhong; Zhu, Beitong; Koo, Seyoung; Tang, Yonghe; Lin, Weiying; James, Tony D.; Kim, Jong Seung

doi:10.1039/d2sc00299j

Cited by 75 publications

(30 citation statements)

References 46 publications

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“…Herein, melt-blown nonwovens were used as a matrix to fabricate test strips because fibers exhibit high surface-to-volume ratios suitable for the adsorption of the sensor and analytes, which is especially beneficial for the detection of gaseous compounds. 39 To increase the load of the probe on the test strips, 15 wt% glycerol was added to the ethanol solution of AQso to increase the viscosity. In addition, the addition of a small amount of glycerol can also provide a polar environment for test strips, thereby promoting the response of AQso to CEES.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Bifunctional Fluorescent Probes for the Detection of Mustard Gas and Phosgene

et al. 2023

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Mustard gas [sulfur mustard (SM)] and phosgene are the most frequently used chemical warfare agents (CWAs), which pose a serious threat to human health and national security, and their rapid and accurate detection is essential to respond to terrorist attacks and industrial accidents. Herein, we developed a fluorescent probe with o-hydroxythioketone as two sensing sites, AQso, which can detect and distinguish mustard gas and phosgene. The dual-sensing-site probe AQso reacts with mustard gas to form a cyclic product with high sensitivity [limit of detection (LOD) = 70 nM] and is highly selective to SM over phosgene, SM analogues, active alkylhalides, acylhalides, and nerve agent mimics, in ethanol solutions. When encountering phosgene, AQso rapidly converts to cyclic carbonate, which is sensitive (LOD = 14 nM) and highly selective. Their sensing mechanisms of AQso to mustard gas and phosgene were well demonstrated by separation and characterization of the sensing products. Furthermore, a facile test strip with the probe was prepared to distinguish 2-chloroethyl ethyl sulfide (CEES) and phosgene in the gas phase by different fluorescence colors and response rates. Not using the complicated instrument, the qualitative and quantitative detection of CEES or phosgene can be achieved only by measuring the red–green–blue (RGB) channel intensity of the test strip after being exposed to CEES or phosgene gas by the smartphone with an RGB color application.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Bifunctional Fluorescent Probes for the Detection of Mustard Gas and Phosgene

et al. 2023

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“…The field of chemosensors for CW agents has seen tremendous progress in the past 20 years with the evolution of, probably, the first fluorescent chemosensor for CW agent mimics reported by Swager. This was followed by studies conducted by many groups, 261 who have inspired countless researchers through their seminal contributions to the field of chemosensors. Most of these reports reveal different combinations of binding or reactive sites and signaling units coupled in different ways to develop selective and sensitive detection systems for diverse CWAs.…”

Section: Discussionmentioning

confidence: 99%

Recent advances in fluorescent and colorimetric chemosensors for the detection of chemical warfare agents: a legacy of the 21st century

et al. 2023

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“…Fluorescence detection is one of the most powerful methods for detecting ecologically and physiologically relevant analytes in the presence of interfering matrices. 58,59 It has attracted considerable attention because it combines the advantages of low-cost and robust detection due to its high sensitivity, great selectivity, fast response time, low detection limit, and ease of use. 60 Fluorescence biosensors can measure intensity, anisotropy, decay time, energy transfer efficiency, and quantum yield.…”

Section: Representative Types For Fluorescence Detection Of Opsmentioning

confidence: 99%

Advances in Noble-Metal Nanoparticle-Based Fluorescence Detection of Organophosphorus Chemical Warfare Agents

et al. 2022

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Efficient and simple detection of chemical warfare agents (CWAs) is an essential step in minimizing the potentially lethal consequences of chemical weapons. CWAs are a family of organic chemicals that are used as chemical weapons because of their enormous severity and lethal effects when faced with unforeseen challenges. To stop the spread of CWAs, it is critical to develop a platform that detects them in a sensitive, timely, selective, and minimally invasive manner. Rapid advances in the demand for on-site sensors, metal nanoparticles, and biomarker identification for CWAs have made it possible to use fluorescence as a precise real-time and point-of-care (POCT) testing technique. For POCT-based applications, the new capabilities of micro- and nanomotors offer enormous prospects. In recent decades, significant progress has been made in the design of fluorescent sensors and the further development of noble metal nanoparticles for the detection of organophosphorus CWAs, as described in this review. Through this work, recent attempts to fabricate sensors that can detect organophosphorus CWAs through changes in their fluorescence properties have been summarized. Finally, an integrated outlook on how noble metal nanoparticles could be used to develop smart sensors for organophosphorus CWAs that communicate with and control electronic devices to monitor and improve the health of individuals.

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A molecular recognition platform for the simultaneous sensing of diverse chemical weapons

Abstract: Chemical warfare agents (CWAs) such as phosgene and nerve agents pose serious threats to our lives and public security, necessitating tools that can simultaneously screen multiple CWAs in seconds.

Cited by 75 publications

References 46 publications

Bifunctional Fluorescent Probes for the Detection of Mustard Gas and Phosgene

Bifunctional Fluorescent Probes for the Detection of Mustard Gas and Phosgene

Recent advances in fluorescent and colorimetric chemosensors for the detection of chemical warfare agents: a legacy of the 21st century

Advances in Noble-Metal Nanoparticle-Based Fluorescence Detection of Organophosphorus Chemical Warfare Agents

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