2014
DOI: 10.1007/s00894-014-2496-x
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A molecular simulation study of the protection of insulin bioactive structure by trehalose

Abstract: Biopharmaceuticals are proteins with a crucial role in the treatment of many diseases. However, these protein medicines are often thermally labile and therefore unsuitable for long-term application and storage, as they tend to lose their activity under ambient conditions. Desiccation is one approach to improving protein stability, but the drying process itself can cause irreversible damage. In the current study, insulin was chosen as an example of a thermally sensitive biopharmaceutical to investigate whether … Show more

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Cited by 6 publications
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“…All of them mainly focused on refining backbone torsional parameters of proteins to balance the conformational equilibrium between helices and extended structures . In the last years, these force fields have been used in simulations of diverse protein systems …”
Section: Introductionmentioning
confidence: 99%
“…All of them mainly focused on refining backbone torsional parameters of proteins to balance the conformational equilibrium between helices and extended structures . In the last years, these force fields have been used in simulations of diverse protein systems …”
Section: Introductionmentioning
confidence: 99%
“…In the absolute majority of these studies, however, systems with an excess of water were studied. Investigations of water distribution in partially hydrated protein systems are sparse. …”
Section: Introductionmentioning
confidence: 99%