A molecularly imprinted biosensor based on water-compatible and electroactive polymeric nanoparticles for lysozyme detection

Yang, Xiaoming; Liu, Huan; Ji, Yuting; Xu, Sheng; Xia, Chunmiao; Zhang, Rongli; Zhang, Cuige; Miao, Zongcheng

doi:10.1016/j.talanta.2021.122891

Cited by 14 publications

(6 citation statements)

References 29 publications

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“…Yang et al used a very different approach: they first synthesized poly(γ-glutamic acid) modified with 3-aminothiophene co-polymer (ATh-γ-PGA). Then they prepared lysozyme-imprinted ATh-γ-PGA NPs using self-assembly and immobilized it on the electrode by electropolymerizing the thiophene groups [61]. Sharma et al synthesized the functional monomer 4-bis(2,2 -bithien-5-yl)methylbenzoic acid glycol ester and successfully prepared an im-printed polymer via electropolymerization in the presence of oxytocin nonapeptide, an autism biomarker [62].…”

Section: Thiophene Derivativesmentioning

confidence: 99%

“…PSA levels are associated with prostate cancer; a corresponding sensor for detecting it in human serum exists in the literature [67] (Table 1). Lysozyme is found in body fluids, and unusual levels may indicate pathological conditions, which was the reason for developing different sensors for Lysozyme [48,61] and cytochrome c [48] (Table 1). As an example for addressing viral markers, Ratautaite et al developed a sensor for the SARS-CoV-2 spike glycoprotein, which has been of crucial importance since the beginning of the coronavirus pandemic [39] (Table 1).…”

Section: Medical Applicationsmentioning

confidence: 99%

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Conductive Molecularly Imprinted Polymers (cMIPs): Rising and Versatile Key Elements in Chemical Sensing

et al. 2023

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Molecularly imprinted polymers (MIPs) have proven useful as receptor materials in chemical sensing and have been reported for a wide range of applications. Based on their simplicity and stability compared to other receptor types, they bear huge application potential related to ongoing digitalization. This is the case especially for conductive molecularly imprinted polymers (cMIPs), which allow easy connection to commercially available sensing platforms; thus, they do not require complex measuring setups. This review provides an overview of the different synthetic approaches toward cMIPs and the obtained limit of detections (LODs) with different transducing systems. In addition, it presents and discusses their use in different application areas to provide a detailed overview of the challenges and possibilities related to cMIP-based sensing systems.

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Section: Thiophene Derivativesmentioning

confidence: 99%

Section: Medical Applicationsmentioning

confidence: 99%

Conductive Molecularly Imprinted Polymers (cMIPs): Rising and Versatile Key Elements in Chemical Sensing

et al. 2023

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“…This biosensor offers an innovative approach for detecting and monitoring xylose fermentation. Yang et al [13] introduced a molecularly imprinted biosensor utilising watercompatible and electroactive polymeric nanoparticles for the detection of lysozyme. This biosensor demonstrates high selectivity and sensitivity in lysozyme detection, providing a valuable tool for various applications.…”

Section: Introductionmentioning

confidence: 99%

A review on the types of nanomaterials and methodologies used for the development of biosensors

Ghosh,

Sagayam,

Haldar

et al. 2024

Adv. Nat. Sci: Nanosci. Nanotechnol.

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Biosensors have gained significant attention in various fields such as food processing, agriculture, environmental monitoring, and healthcare. With the continuous advancements in research and technology, a wide variety of biosensors are being developed to cater to diverse applications. However, the effective development of nanobiosensors, particularly the synthesis of nanomaterials, remains a crucial step. Many nanobiosensors face challenges related to instability and selectivity, making it difficult to achieve proper packaging. While some biosensors have been successfully implemented in commercial settings, there is a pressing need to address their limitations and advance their capabilities. The next generation of biosensors, based on nanomaterials, holds promise in overcoming these challenges and enhancing the overall performance of biosensor devices. The commercial viability of these biosensors will rely on their accuracy, reliability, and cost-effectiveness. This review paper provides an overview of various types of nanomaterials and their applications in the development of nanobiosensors. The paper highlights a comparison of different nanomaterial-based biosensors, discussing their advantages, limitations, and performance characteristics.

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“…The range of measurable BOD 5 values was 4–60 mgO 2 /dm 3 , and the system was stable for 60 days. It should be noted that currently developed microbial biosensors based on similar conductive materials exhibit poor performance, although this approach is very effective in the field of enzyme biosensors [ 7 , 10 , 22 ]. In addition, these examples refer to the use of bacterial microorganisms.…”

Section: Introductionmentioning

confidence: 99%

A Two-Mediator System Based on a Nanocomposite of Redox-Active Polymer Poly(thionine) and SWCNT as an Effective Electron Carrier for Eukaryotic Microorganisms in Biosensor Analyzers

Medvedeva,

Dyakova,

Kuznetsova

et al. 2023

Polymers

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Electropolymerized thionine was used as a redox-active polymer to create a two-mediated microbial biosensor for determining biochemical oxygen demand (BOD). The electrochemical characteristics of the conducting system were studied by cyclic voltammetry and electrochemical impedance spectroscopy. It has been shown that the most promising in terms of the rate of interaction with the yeast B. adeninivorans is the system based on poly(thionine), single-walled carbon nanotubes (SWCNT), and neutral red (kint = 0.071 dm3/(g·s)). The biosensor based on this system is characterized by high sensitivity (the lower limit of determined BOD concentrations is 0.4 mgO2/dm3). Sample analysis by means of the developed analytical system showed that the results of the standard dilution method and those using the biosensor differed insignificantly. Thus, for the first time, the fundamental possibility of effectively using nanocomposite materials based on SWCNT and the redox-active polymer poly(thionine) as one of the components of two-mediator systems for electron transfer from yeast microorganisms to the electrode has been shown. It opens up prospects for creating stable and highly sensitive electrochemical systems based on eukaryotes.

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A molecularly imprinted biosensor based on water-compatible and electroactive polymeric nanoparticles for lysozyme detection

Cited by 14 publications

References 29 publications

Conductive Molecularly Imprinted Polymers (cMIPs): Rising and Versatile Key Elements in Chemical Sensing

Conductive Molecularly Imprinted Polymers (cMIPs): Rising and Versatile Key Elements in Chemical Sensing

A review on the types of nanomaterials and methodologies used for the development of biosensors

A Two-Mediator System Based on a Nanocomposite of Redox-Active Polymer Poly(thionine) and SWCNT as an Effective Electron Carrier for Eukaryotic Microorganisms in Biosensor Analyzers

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