A Monte Carlo brachytherapy study for dose distribution prediction in an inhomogeneous medium

Slate, Lawrence J.; Elson, Howard R.; Lamba, Michael; Kassing, W; Soldano, M.; Barrett, William L.

doi:10.1016/j.meddos.2004.02.002

Cited by 7 publications

(2 citation statements)

References 12 publications

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“…According to this protocol, dosimetric parameters around brachytherapy sources are obtained by experimental measurement or simulation techniques using the Monte Carlo codes in a uniform water phantom. 10 - 11 Monte Carlo is a computational technique for solving problems in various fields including physical and mathematical sciences. This method is based on random sampling to achieve the required results.…”

Section: Introductionmentioning

confidence: 99%

Determination of dosimetric parameters for shielded ¹⁵³Gd source in prostate cancer brachytherapy

Ghorbani

Khajetash

Ghatei

et al. 2017

Radiology and Oncology

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BackgroundInterstitial rotating shield brachytherapy (I-RSBT) is a recently developed method for treatment of prostate cancer. In the present study TG-43 dosimetric parameters of a 153Gd source were obtained for use in I-RSBT.Materials and methodsA 153Gd source located inside a needle including a Pt shield and an aluminum window was simulated using MCNPX Monte Carlo code. Dosimetric parameters of this source model, including air kerma strength, dose rate constant, radial dose function and 2D anisotropy function, with and without the shields were calculated according to the TG-43 report.ResultsThe air kerma strength was found to be 6.71 U for the non-shielded source with 1 GBq activity. This value was found to be 0.04 U and 6.19 U for the Pt shield and Al window cases, respectively. Dose rate constant for the non-shielded source was found to be 1.20 cGy/(hU). However, for a shielded source with Pt and aluminum window, dose rate constants were found to be 0.07 cGy/(hU) and 0.96 cGy/(hU), on the shielded and window sides, respectively. The values of radial dose function and anisotropy function were tabulated for these sources. Additionally, isodose curves were drawn for sources with and without shield, in order to evaluate the effect of shield on dose distribution.ConclusionsExistence of the Pt shield may greatly reduce the dose to organs at risk and normal tissues which are located toward the shielded side. The calculated air kerma strength, dose rate constant, radial dose function and 2D anisotropy function data for the 153Gd source for the non-shielded and the shielded sources can be used in the treatment planning system (TPS).

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Section: Introductionmentioning

confidence: 99%

Determination of dosimetric parameters for shielded ¹⁵³Gd source in prostate cancer brachytherapy

Ghorbani

Khajetash

Ghatei

et al. 2017

Radiology and Oncology

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“…Lately, MC has been shown to be also a meaningful dose calculation tool for brachytherapy, especially for regions near the radioactive source, in the presence of inhomogeneities and in cases where the source is placed near the patient surface. [12][13][14][15] However, brachytherapy dose calculations in commercial TPSs are just performed based on precalculated dose kernels determined with MC simulations in a homogeneous water phantom. Consequently, in brachytherapy treatment planning systems ͑TPSs͒, patient shape and anatomy are not taken into account.…”

Section: Introductionmentioning

confidence: 99%

Validation for photon beams in the energy range of 20–1000 keV

et al. 2010

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Photon activation therapy: a Monte Carlo study on dose enhancement by various sources and activation media

Bakhshabadi

Ghorbani

Meigooni

2013

Australas Phys Eng Sci Med

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In the present study, a number of brachytherapy sources and activation media were simulated using MCNPX code and the results were analyzed based on the dose enhancement factor values. Furthermore, two new brachytherapy sources (¹³¹Cs and a hypothetical ¹⁷⁰Tm) were evaluated for their application in photon activation therapy (PAT). ¹²⁵I, ¹⁰³Pd, ¹³¹Cs and hypothetical ¹⁷⁰Tm brachytherapy sources were simulated in water and their dose rate constant and the radial dose functions were compared with previously published data. The sources were then simulated in a soft tissue phantom which was composed of Ag, I, Pt or Au as activation media uniformly distributed in the tumour volume. These simulations were performed using the MCNPX code, and dose enhancement factor (DEF) was obtained for 7, 18 and 30 mg/ml concentrations of the activation media. Each source, activation medium and concentration was evaluated separately in a separate simulation. The calculated dose rate constant and radial dose functions were in agreement with the published data for the aforementioned sources. The maximum DEF was found to be 5.58 for a combination of the ¹⁷⁰Tm source with 30 mg/ml concentration of I. The DEFs for ¹³¹Cs and ¹⁷⁰Tm sources for all the four activation media were higher than those for other sources and activation media. From this point of view, these two sources can be more useful in photon activation therapy with photon emitter sources. Furthermore, ¹³¹Cs and ¹⁷⁰Tm brachytherapy sources can be proposed as new options for use in the field of PAT.

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A Monte Carlo brachytherapy study for dose distribution prediction in an inhomogeneous medium

Cited by 7 publications

References 12 publications

Determination of dosimetric parameters for shielded ¹⁵³Gd source in prostate cancer brachytherapy

Determination of dosimetric parameters for shielded ¹⁵³Gd source in prostate cancer brachytherapy

Validation for photon beams in the energy range of 20–1000 keV

Photon activation therapy: a Monte Carlo study on dose enhancement by various sources and activation media

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A Monte Carlo brachytherapy study for dose distribution prediction in an inhomogeneous medium

Cited by 7 publications

References 12 publications

Determination of dosimetric parameters for shielded 153Gd source in prostate cancer brachytherapy

Determination of dosimetric parameters for shielded 153Gd source in prostate cancer brachytherapy

Validation for photon beams in the energy range of 20–1000 keV

Photon activation therapy: a Monte Carlo study on dose enhancement by various sources and activation media

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Determination of dosimetric parameters for shielded ¹⁵³Gd source in prostate cancer brachytherapy

Determination of dosimetric parameters for shielded ¹⁵³Gd source in prostate cancer brachytherapy