A multi-biomarker approach using integrated biomarker response to assess the effect of pH on triclosan toxicity in Pangasianodon hypophthalmus (Sauvage, 1878)

Paul, Tapas; Kumar, Saurav; Shukla, Satya Prakash; Pal, Prasenjit; Kumar, Kundan; Poojary, Nalini; Biswal, Abhilipsa; Mishra, Archana

doi:10.1016/j.envpol.2020.114001

Cited by 46 publications

(7 citation statements)

References 47 publications

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“…Based on IBR analysis, GSH, GSSG, AChE, AST, ALT could be ascertained as biomarkers for the stress of sublethal concentrations of TCS. Our results are in agreement with Paul et al 76 .…”

Section: Discussionsupporting

confidence: 94%

Biomarkers for the toxicity of sublethal concentrations of triclosan to the early life stages of carps

Dar

Sharma

Singh

et al. 2020

Sci Rep

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Accumulation, contents of protein, non-enzymatic antioxidant glutathione (GSH and GSSG), lipid peroxidation product (melondialdehyde-MDA) and organic acids (fumarate, succinate, malate and citrate), and activities of neurological (acetylcholinesterase-AChE), detoxification (glutathione S-transferase-GST) and metabolic (lactate dehydrogenase-LDH, aspartate transaminase-AST and alanine transaminase-ALT) enzymes were recorded in the hatchlings of Cyprinus carpio, Ctenopharyngodon idella, Labeo rohita and Cirrhinus mrigala after 7 and 14 days exposure and 10 days post exposure (recovery period) to sublethal concentrations (0.005, 0.01, 0.02 and 0.05 mg/L) of triclosan, a highly toxic and persistent biocide used in personal care products. Accumulation was maximum between 7–14 days at 0.01 mg/L for C. carpio and L. rohita but at 0.005 mg/L for C. idella and C. mrigala. No triclosan was observed at 0.005 mg/L in C. carpio and C. mrigala after recovery. Significant decline in protein, glutathione and acetylcholinesterase but increase in glutathione S-transferase, lactate dehydrogenase, aspartate transaminase, alanine transaminase, melondialdehyde and organic acids over control during exposure continued till the end of recovery period. Integrated biomarker response (IBR) analysis depicted higher star plot area for glutathione and glutathione S-transferase during initial 7 days of exposure, thereafter, during 7–14 days of exposure and the recovery period, higher star plot area was observed for acetylcholinesterase, aspartate transaminase, alanine transaminase and organic acids. Higher star plot area was observed for protein in all the species throughout the study. The study shows that L. rohita is most sensitive and glutathione, acetylcholinesterase, aspartate transaminase and alanine transaminase are the biomarkers for the toxicity of sublethal concentrations of TCS.

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“…Based on IBR analysis, GSH, GSSG, AChE, AST, ALT could be ascertained as biomarkers for the stress of sublethal concentrations of TCS. Our results are in agreement with Paul et al 76 .…”

Section: Discussionsupporting

confidence: 94%

Biomarkers for the toxicity of sublethal concentrations of triclosan to the early life stages of carps

Dar

Sharma

Singh

et al. 2020

Sci Rep

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“…The IBR index showed higher mean value in the control group for each biomarker, attributing to increased oxidative stress, alteration in hormones, and metabolizing enzymes to meet energy demand during transportation stress 8,14 . Similar studies of measuring stress response by IBR were reported by Li et al and Paul et al in different organs of fish exposed to pollutant stress 11,40 .…”

Section: Discussionsupporting

confidence: 81%

“…Due to the higher potency of 0.2% glucose treatment, fish has lesser demand for additional energy during the long-term transportation stress resulting in the lowest LDH and MDH activity. Variation in antioxidant enzymes activity can be used as the indicator of stress in fish 11,37 . Oxidative stress biomarker such as SOD catalyzes the conversion of the superoxide anion into hydrogen peroxide and molecular oxygen, invariably CAT activity decomposes the hydrogen peroxide into oxygen and water 38 .…”

Section: Discussionmentioning

confidence: 99%

An Integrated biomarker approach for explaining the potency of exogenous glucose on transportation induced stress in Labeo rohita fingerlings

Biswal

Srivastava

Krishna

et al. 2021

Sci Rep

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Transportation of fish seed is a complex phenomenon associated with multiple kinds of stressors that simultaneously affect the fish in a confined environment, causing stress and mortality. The present study investigated the stress-relieving effect of exogenous glucose as a water additive in different concentrations (0.1, 0.2, 0.3, and 0.4%) during simulated transportation (12 h) of L. rohita fingerlings. The integrated biomarker response (IBR) index is a holistic tool to determine the optimum dose of exogenous glucose for mitigating transportation stress in fish. Based on selected biomarkers related to the stress hormone, serum biochemistry, oxidative stress, and HSP70 mRNA expression, the IBR index is calculated for each treatment and control group. The result showed a significant change in the level of stress hormone cortisol, enzymes (SGPT, LDH, MDH, SOD, CAT) and metabolites (serum glucose, triglyceride, creatinine) along with an upregulation in liver HSP70 mRNA expression. IBR index suggests that 0.2% glucose exhibited the lowest multi-biomarker stress response in comparison to other treatments and control. Therefore, the use of 0.2% glucose as a water additive will provide a solution to transportation induced stress in L. rohita fingerling and will underwrite the success of grow-out fish culture in days to come.

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“…These transformations take place mainly in the liver, but the processes of elimination of this compound from the animal's body depend on many factors, including the species, the dose taken, and environmental conditions. The toxicity of triclosan to aquatic organisms, including fish, is manifested by its effect on increasing the level of oxidative stress, its neurotoxic, genotoxic, endocrine disrupting, and behavioral effects (Dar et al, 2020; Gyimah et al, 2020; Paul et al, 2020; Raut & Angus, 2009; Weatherly & Gosse, 2017). The species in which triclosan and its derivatives have been detected include the following: Cyprinus carpio , Gibelion catla , L. hoffmeisteri , Tursiops truncates , Lepomis macrochirus , and Rutilus rutilus (Kumar et al, 2021).…”

Section: Impact Of Triclosan On the Environment And Its Toxicitymentioning

confidence: 99%

A review on triclosan in wastewater: Mechanism of action, resistance phenomenon, environmental risks, and sustainable removal techniques

Jabłońska‐Trypuć

2023

Water Environment Research

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Triclosan, belonging to the bisphenols, is known antiseptic broad‐spectrum biocide. It has a very wide range of applications, both in health care, as well as in the household. Triclosan enters the environment, both water bodies and soil, because of its high prevalence and the ability to accumulation. Excessive use of antimicrobial formulations may cause the generation of resistance among microorganisms. Reduced susceptibility to triclosan is observed more frequently and in an expanded group of microorganisms, and is conditioned by a number of different mechanisms occurring on the molecular level. Conventional wastewater treatment processes are not always able to provide a reliable barrier to triclosan. Therefore, additional advanced treatment technologies are being considered in areas, where a triclosan contamination problem has been identified. Removal of triclosan from wastewater is carried out using different biological and chemical techniques, however it should be pointed out that physico‐chemical methods often generate toxic by‐products. Toxicity of triclosan and its degradation products, bacterial resistance to this compound and evident problems with triclosan elimination from wastewater are currently the main problems faced by companies creating products containing triclosan.

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A multi-biomarker approach using integrated biomarker response to assess the effect of pH on triclosan toxicity in Pangasianodon hypophthalmus (Sauvage, 1878)

Cited by 46 publications

References 47 publications

Biomarkers for the toxicity of sublethal concentrations of triclosan to the early life stages of carps

Biomarkers for the toxicity of sublethal concentrations of triclosan to the early life stages of carps

An Integrated biomarker approach for explaining the potency of exogenous glucose on transportation induced stress in Labeo rohita fingerlings

A review on triclosan in wastewater: Mechanism of action, resistance phenomenon, environmental risks, and sustainable removal techniques

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