A multi-center study on glucometabolic response to bariatric surgery for different subtypes of obesity

Abstract

ObjectivesTo assess the benefit of a bariatric surgery in four artificial intelligence-identified metabolic (AIM) subtypes of obesity with respect to the improvement of glucometabolism and the remission of diabetes and hyperinsulinemia.MethodsThis multicenter retrospective study prospectively collected data from five hospitals in China from 2010 to 2021. At baseline 1008 patients who underwent a bariatric surgery were enrolled (median age 31 years; median BMI 38.1kg/m2; 57.40% women) and grouped into the four AIM subtypes. Baseline and follow-up data (506 and 359 patients at 3- and 12-month post-surgery) were collected for longitudinal effect analysis.ResultsOut of the four AIM subgroups, hypometabolic obesity (LMO) group was characterized by decompensated insulin secretion and high incidence of diabetes (99.2%) pre-surgery. After surgery, 62.1% of LMO patients with diabetes achieved remission, lower than the other three subgroups. Still, the bariatric surgery significantly reduced their blood glucose (median HbA1c decreased by 27.2%). The hypermetabolic obesity-hyperinsulinemia (HMO-I) group was characterized by severe insulin resistance and high incidence of hyperinsulinemia (87.8%) pre-surgery, which had been greatly alleviated post-surgery. For both metabolic healthy obesity (MHO) and hypermetabolic obesity-hyperuricemia (HMO-U) groups who showed a relatively healthy glucometabolism pre-surgery, rate of glucometabolic comorbidities improved moderately post-surgery.ConclusionIn terms of glucometabolism, the four AIM subtypes of patients benefited differently from a bariatric surgery, which significantly relieved hyperglycemia and hyperinsulinemia for the LMO and HMO-I patients, respectively. The AIM-based subtypes may help better inform clinical decisions on bariatric surgery and patient counseling pertaining to post-surgery outcomes.

One Anastomosis Gastric Bypass Surgery: Consequences Over Diabetic Parameters

“…Paired sample t-test was applied to see the difference between baseline with follow-ups 1 & 2.blood glucose levels following the surgery. A similar finding was reported by Liu et al, in 202245 . They observed a median HbA1c decrease of 27.2% following bariatric surgery.…”

“…HbA1c decreased in this study, suggesting improved that loss of weight and restriction of calories may have a significant role in such outcomes. They also suggested that other causes, such as decreased inflammatory factors production from adipose tissue, raised release of hormones from the gastrointestinal tract, gut microflora changes, and alterations in the concentration of branched amino acids or bile within the circulation contribute to the improvement of HbA1c [45][46][47] [Figure 4].…”