A multi-functional double cross-linked chitosan hydrogel with tunable mechanical and antibacterial properties for skin wound dressing

Liu, Fengling; Wang, Lu; Zhai, Xinrang; Ji, Shunxian; Ye, Jingjia; Zhu, Zhiqiang; Teng, Chong; Dong, Wei; Wei, Wei

doi:10.1016/j.carbpol.2023.121344

Cited by 27 publications

(9 citation statements)

References 42 publications

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“…Comparatively, CTSMA/CTSSH (CMS) hydrogels demonstrated superior tissue adhesion and mechanical properties when compared to pure CTSMA hydrogels. Furthermore, this chitosan-based hydrogel showed potential in wound healing through its ability to promote angiogenesis, dermal repair, and epidermal regeneration [103].…”

Section: Proliferation Stagementioning

confidence: 99%

Application of Chitosan-Based Hydrogel in Promoting Wound Healing: A Review

Che,

Zhao,

et al. 2024

Polymers

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Chitosan is a linear polyelectrolyte with active hydroxyl and amino groups that can be made into chitosan-based hydrogels by different cross-linking methods. Chitosan-based hydrogels also have a three-dimensional network of hydrogels, which can accommodate a large number of aqueous solvents and biofluids. CS, as an ideal drug-carrying material, can effectively encapsulate and protect drugs and has the advantages of being nontoxic, biocompatible, and biodegradable. These advantages make it an ideal material for the preparation of functional hydrogels that can act as wound dressings for skin injuries. This review reports the role of chitosan-based hydrogels in promoting skin repair in the context of the mechanisms involved in skin injury repair. Chitosan-based hydrogels were found to promote skin repair at different process stages. Various functional chitosan-based hydrogels are also discussed.

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Section: Proliferation Stagementioning

confidence: 99%

Application of Chitosan-Based Hydrogel in Promoting Wound Healing: A Review

Che,

Zhao,

et al. 2024

Polymers

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“…Chitosan hydrogel, a natural polymer that is both biocompatible and biodegradable, carries a low risk of causing inflammation in the skin. [ 103–106 ] Additionally, it has been demonstrated that chitosan could promote the transformation of macrophages from pro‐inflammatory M1 type to anti‐inflammatory M2 type and stimulate the expression of related anti‐inflammatory factors. [ 107,108 ] Modified chitosan hydrogels allow for sustained topical delivery by loading anti‐inflammatory and analgesic drugs.…”

Section: Routes Of Administrationmentioning

confidence: 99%

Advances in Stimuli‐Responsive Chitosan Hydrogels for Drug Delivery Systems

Xia,

Ma,

et al. 2023

Macromolecular Bioscience

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Sustainable and controllable drug transport is one of the most efficient ways of disease treatment. Due to high biocompatibility, good biodegradability, and low costs, chitosan and its derivatives are widely used in biomedical fields. Specifically, chitosan hydrogel enables drugs to pass through biological barriers because of their abundant amino and hydroxyl groups that can interact with human tissues. Moreover, the multi‐responsive nature (pH, temperature, ions strength, and magnetic field, etc.) of chitosan hydrogels makes precise drug release a possibility. Here, the synthesis methods, modification strategies, stimuli‐responsive mechanisms of chitosan‐based hydrogels, and their recent progress in drug delivery are summarized. Chitosan hydrogels that carry and release drugs through subcutaneous (dealing with wound dressing), oral (dealing with gastrointestinal tract), and facial (dealing with ophthalmic, ear, and brain) are reviewed. Finally, challenges toward clinic application and the future prospects of stimuli‐responsive chitosan‐based hydrogels are indicated.

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“…Hydrogels have a well-designed structure, flexibility, and antibacterial effect, which makes them good candidates for the preparation of wound dressings. 4,10–15 However, a single-component hydrogel isolates bacteria only. Therefore, the composition of a hydrogel needs to be adjusted further to aid skin repair.…”

Section: Introductionmentioning

confidence: 99%

“…Light is usually added to accelerate skin repair. 4,11,12,22 Therefore, materials used as wound dressings also need to have a good light-transmitting effect. Moreover, if the materials have a photothermal effect then wound healing can be greatly promoted.…”

Section: Introductionmentioning

confidence: 99%