A multi-omic approach reveals utility of CD45 expression in prognosis and novel target discovery

Abstract

CD45, the leukocyte common antigen, is expressed on almost all cells of the immunological and hematological systems. CD45 expression is related to a variety of diseases, including leukemia and lymphoma. In this study, we analyzed the expression level of CD45 across cancers and evaluated the relationship between its expression and patient prognosis. We further integrated methylation data to explore the differences in CD45 across cancers from a multi-omics perspective. We also analyzed the relationship between CD45 expression and levels of immune cell infiltrates and immune modifiers. Our results revealed the distinct expression characteristics and prognostic value of CD45 across multiple tumors. In addition, we screened drug targets based on the immune index defined by CD45 expression and identified that GPR84 affected the proliferation of tumor cells and was associated with the inflammation caused by immunotherapy. In summary, our findings provide a comprehensive understanding of the role of CD45 in oncogenesis and its prognostic significance across cancers.

Identifying potential immuno‐oncology targets in salivary gland mucoepidermoid carcinoma based on inflammatory status and treatment response

“…A striking difference in pan‐immune leukocyte expression (CD45) was observed between responders and non‐responders, particularly within the tumour neighbourhoods. More recently, a positive correlation between CD45 expression and the presence of immune cell infiltrates and immune modifiers has been observed, where unique CD45 expression patterns were associated with various types of tumours, providing valuable prognostic insights 27 . These reports and our observations herein highlight the importance of CD45 as a valuable biomarker within the TME.…”

“…More recently, a positive correlation between CD45 expression and the presence of immune cell infiltrates and immune modifiers has been observed, where unique CD45 expression patterns were associated with various types of tumours, providing valuable prognostic insights. 27 These reports and our observations herein highlight the importance of CD45 as a valuable biomarker within the TME. On the contrary, the expression profiles of PD-1 and CD68 did not show robust differences between inflammatory/immune subtypes or treatment response groups.…”

Carbonic anhydrases reduce the acidity of the tumor microenvironment, promote immune infiltration, decelerate tumor growth, and improve survival in ErbB2/HER2-enriched breast cancer

“…11 ). Initially, we observe that CD45 expression—which correlates with leucocyte infiltration [ 63 ]—among the breast cancer molecular subtypes is highest in HER2-enriched breast cancer (Fig. 11 A).…”

Oncostatin M and Nivolumab Affect the Cytotoxic T-Cell Proportions and the Susceptibility to TRAIL-Induced Death in Non-Leukocyte Cell Subpopulations in Soft Tissue Sarcomas

“…Moreover, high levels of CD45 were shown to significantly increase the local recurrence-free survival and the disease-specific survival in patients with head and neck cancer [36]. Similarly, the expression level of CD45 was related to good prognosis in multiple tumors, such as lung adenocarcinoma or skin cutaneous melanoma [37].…”