2024
DOI: 10.1002/jcsm.13550
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A multi‐omics approach to overeating and inactivity‐induced muscle atrophy in db/db mice

Takuro Okamura,
Masahide Hamaguchi,
Genki Kobayashi
et al.

Abstract: BackgroundOvereating and inactivity are associated with type 2 diabetes. This study aimed to investigate its pathological basis using integrated omics and db/db/mice, a model representing this condition.MethodsThe study involved housing 8‐week‐old db/m and db/db mice for 8 weeks. Various analyses were conducted, including gene expression in skeletal muscle and small intestine using next‐generation sequencing; cytokine arrays of serum; assessment of metabolites in skeletal muscle, stool, and serum; and analysis… Show more

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