A multi-responsive targeting drug delivery system for combination photothermal/chemotherapy of tumor

Yang, Yuanyuan; Wu, Siqi; Zhang, Qinlin; Chen, Zhaoxia; Wang, Caixia; Jiang, Sijing; Zhang, Yuhong

doi:10.1080/09205063.2022.2112310

Cited by 6 publications

(2 citation statements)

References 55 publications

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“…Nanocarriers possessing mesoporous architectures exhibit a notable specific surface area and large pore volume, thereby showcasing immense potential as nano-drug delivery systems. 30 Heretofore, different kinds of mesoporous materials have been applied as excellent drug-loading nanocarriers, which were usually loaded with drug molecules through non-covalent electrostatic, π–π stacking and hydrogen bonding. 31 , 32 Owing to its large specific surface area and ease of surface functionalization, aminated mesoporous graphene oxide (rPGO) has significant potential as a drug delivery carrier.…”

Section: Resultsmentioning

confidence: 99%

Mesoporous Graphene Oxide Nanocomposite Effective for Combined Chemo/Photo Therapy Against Non-Small Cell Lung Cancer

Zhang,

Zheng,

Zhang

et al. 2024

IJN

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Introduction Lung cancer is the most common cancer worldwide, among which non-small cell lung cancer (NSCLC) accounts for about 80% of all lung cancers. Chemotherapy, a mainstay modality for NSCLC, has demonstrated restricted effectiveness due to the emergence of chemo-resistance and systemic side effects. Studies have indicated that combining chemotherapy with phototherapy, such as photodynamic therapy (PDT) and photothermal therapy (PTT), can enhance efficacy of therapy. In this work, an aminated mesoporous graphene oxide (rPGO)-protoporphyrin IX (PPIX)-hyaluronic acid (HA)@Osimertinib (AZD) nanodrug delivery system (rPPH@AZD) was successfully developed for combined chemotherapy/phototherapy for NSCLC. Methods A pH/hyaluronidase-responsive nanodrug delivery system (rPPH@AZD) was prepared using mesoporous graphene oxide. Its morphology, elemental composition, surface functional groups, optical properties, in vitro drug release ability, photothermal properties, reactive oxygen species production, cellular uptake and cell viability were evaluated. In addition, the in vivo therapeutic effect, biocompatibility, and imaging capabilities of rPPH@AZD were verified by a tumor-bearing mouse model. Results Aminated mesoporous graphene oxide (rPGO) plays a role as a drug delivery vehicle owing to its large specific surface area and ease of surface functionalization. rPGO exhibits excellent photothermal conversion properties under laser irradiation, while PPIX acts as a photosensitizer to generate singlet oxygen. AZD acts as a small molecule targeted drug in chemotherapy. In essence, rPPH@AZD shows excellent photothermal and fluorescence imaging effects in tumor-bearing mice. More importantly, in vitro and in vivo results indicate that rPPH@AZD can achieve hyaluronidase/pH dual response as well as combined chemotherapy/PTT/PDT anti-NSCLC treatment. Conclusion The newly prepared rPPH@AZD can serve as a promising pH/hyaluronidase-responsive nanodrug delivery system that integrates photothermal/fluorescence imaging and chemo/photo combined therapy for efficient therapy against NSCLC.

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Section: Resultsmentioning

confidence: 99%

Mesoporous Graphene Oxide Nanocomposite Effective for Combined Chemo/Photo Therapy Against Non-Small Cell Lung Cancer

Zhang,

Zheng,

Zhang

et al. 2024

IJN

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“…There are many different types of drug delivery systems, including micro- [ 2 ] and nanoparticles [ 3 ], nanoplatforms [ 4 , 5 , 6 ], devices [ 7 , 8 , 9 , 10 ], and theragnostic platforms [ 11 , 12 , 13 ]. These systems can be used to deliver a wide range of drugs, including chemotherapeutics [ 14 , 15 , 16 ], gene therapies [ 17 , 18 , 19 , 20 ], and other biologics [ 21 , 22 , 23 , 24 , 25 , 26 ]. Optimizing drug loading in drug delivery systems is a critical aspect of their design and performance.…”

Section: Introductionmentioning

confidence: 99%

Gold Nanoparticles as Drug Carriers: The Role of Silica and PEG as Surface Coatings in Optimizing Drug Loading

2023

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The use of gold nanoparticles as drug delivery systems has received increasing attention due to their unique properties, such as their high stability and biocompatibility. However, gold nanoparticles have a high affinity for proteins, which can result in their rapid clearance from the body and limited drug loading capabilities. To address these limitations, we coated the gold nanoparticles with silica and PEG, which are known to improve the stability of nanoparticles. The synthesis of the nanoparticles was carried out using a reduction method. The nanoparticles’ size, morphology, and drug loading capacity were also studied. The SEM images showed a spherical and homogeneous morphology; they also showed that the coatings increased the average size of the nanoparticles. The results of this study provide insight into the potential of gold nanoparticles coated with silica and PEG as drug delivery systems. We used ibuprofen as a model drug and found that the highest drug load occurred in PEG-coated nanoparticles and then in silica-coated nanoparticles, while the uncoated nanoparticles had a lower drug loading capacity. The coatings were found to significantly improve the stability and drug load properties of the nanoparticles, making them promising candidates for further development as targeted and controlled release drug delivery systems.

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Complexed hyaluronic acid-based nanoparticles in cancer therapy and diagnosis: Research trends by natural language processing

Umar,

Limpikirati,

Rivai

et al. 2025

Heliyon

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A multi-responsive targeting drug delivery system for combination photothermal/chemotherapy of tumor

Cited by 6 publications

References 55 publications

Mesoporous Graphene Oxide Nanocomposite Effective for Combined Chemo/Photo Therapy Against Non-Small Cell Lung Cancer

Mesoporous Graphene Oxide Nanocomposite Effective for Combined Chemo/Photo Therapy Against Non-Small Cell Lung Cancer

Gold Nanoparticles as Drug Carriers: The Role of Silica and PEG as Surface Coatings in Optimizing Drug Loading

Complexed hyaluronic acid-based nanoparticles in cancer therapy and diagnosis: Research trends by natural language processing

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