A multi-strategy platform for Q-markers screening and quality control of Wuzi Yanzong Wan based on fingerprint and network pharmacology

Dong, Bao-Hua; Wu, Jie; Peng, Ying; Jiang, Yun-Xiu; Cao, Ma-Yi-Jie; Huang, Yu; Hu, Chang-Jiang; Yu, Ling-ying; Chen, Zhi-Min

doi:10.1016/j.arabjc.2023.105435

Arabian Journal of Chemistry

2024

DOI: 10.1016/j.arabjc.2023.105435

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A multi-strategy platform for Q-markers screening and quality control of Wuzi Yanzong Wan based on fingerprint and network pharmacology

Bao-Hua Dong,

Jie Wu,

Ying Peng

et al.

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Cited by 3 publications

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Wuzi Yanzong Decoction Ameliorates Oligoasthenozoospermia by Up‐Regulating Methyltransferase and Increasing Spata, Bcl, and Pik3 Series Genes Methylation Level

Lin,

Ge,

et al. 2024

Chemistry & Biodiversity

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Wuzi Yanzong decoction (WZYZD) belongs to the traditional formula for treating male infertility caused by oligoasthenozoospermia (OLI). This research aims to elucidate the therapeutic substance basis and potential pharmacological mechanisms of WZYZD in treating OLI. A total of 52 chemical ingredients were identified from WZYZD. HE and TUNEL staining demonstrated that WZYZD can markedly alleviate OLI. Immunofluorescence analysis showed that WZYZD can significantly increase the expression levels of DNMT3A, PIWIL1, SETDB1, and PRMT5. Methyl capture sequencing proved that WZYZD can markedly upregulate the methylated level of Spata, Bcl, and Pik3 series genes. Network pharmacology analysis proved that WZYZD can ameliorate OLI through BCL‐2 and PI3K‐AKT signaling pathways. The immunofluorescence assay of BCL‐2 and SPATA18 proved the aforementioned results. The potential mechanism of WZYZD in treating OLI mainly involved recruiting methyltransferase DNMT3A, PIWIL1, PRMT5, and SETDB1 and increasing the methylation degree of Spata, Bcl, and Pik3 series genes.

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Wuzi Yanzong Decoction Ameliorates Oligoasthenozoospermia by Up‐Regulating Methyltransferase and Increasing Spata, Bcl, and Pik3 Series Genes Methylation Level

Lin,

Ge,

et al. 2024

Chemistry & Biodiversity

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Quantitative analysis of active components in Rhodiola species based on disease module-guided network pharmacology

Zhu,

Jin,

et al. 2024

Arabian Journal of Chemistry

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Component analysis using UPLC-Q-TOF/MS and quality evaluation using fingerprinting and chemometrics for hops

Gao,

Wang,

et al. 2024

Food Chemistry

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A multi-strategy platform for Q-markers screening and quality control of Wuzi Yanzong Wan based on fingerprint and network pharmacology

Cited by 3 publications

References 32 publications

Wuzi Yanzong Decoction Ameliorates Oligoasthenozoospermia by Up‐Regulating Methyltransferase and Increasing Spata, Bcl, and Pik3 Series Genes Methylation Level

Wuzi Yanzong Decoction Ameliorates Oligoasthenozoospermia by Up‐Regulating Methyltransferase and Increasing Spata, Bcl, and Pik3 Series Genes Methylation Level

Quantitative analysis of active components in Rhodiola species based on disease module-guided network pharmacology

Component analysis using UPLC-Q-TOF/MS and quality evaluation using fingerprinting and chemometrics for hops

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