A multi-target directed ligands strategy for the treatment of Alzheimer's disease: Dimethyl fumarate plus Tranilast modified Dithiocarbate as AChE inhibitor and Nrf2 activator

Guo, Jie; Cheng, Maojun; Liu, Peng; Cao, Duanyuan; Luo, Jinchong; Wan, Yang; Yuan, Fang; Jin, Yi; Xie, Sai‐Sai; Liu, Jing

doi:10.1016/j.ejmech.2022.114630

Cited by 19 publications

(4 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the context of AD, another multitarget approach was achieved through the preparation of merged ligands with dual pharmacological activity and subsequent structural optimization [ 100 ].…”

Section: Multitargeting Nrf2 Activatorsmentioning

confidence: 99%

Activators of Nrf2 to Counteract Neurodegenerative Diseases

2023

View full text Add to dashboard Cite

Neurodegenerative diseases are incurable and debilitating conditions that result in progressive degeneration and loss of nerve cells. Oxidative stress has been proposed as one factor that plays a potential role in the pathogenesis of neurodegenerative disorders since neuron cells are particularly vulnerable to oxidative damage. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is strictly related to anti-inflammatory and antioxidative cell response; therefore, its activation and the consequent enhancement of the related cellular pathways have been proposed as a potential therapeutic approach. Several Nrf2 activators with different mechanisms and diverse structures have been reported, but those applied for neurodisorders are still limited. However, in the very last few years, interesting progress has been made, particularly in enhancing the blood–brain barrier penetration, to make Nrf2 activators effective drugs, and in designing Nrf2-based multitarget-directed ligands to affect multiple pathways involved in the pathology of neurodegenerative diseases. The present review gives an overview of the most representative findings in this research area.

show abstract

Section: Multitargeting Nrf2 Activatorsmentioning

confidence: 99%

Activators of Nrf2 to Counteract Neurodegenerative Diseases

2023

View full text Add to dashboard Cite

show abstract

“…NRF2 is a master regulator of antioxidant responses and has been shown to regulate mitochondrial bioenergetics 37 . When activated, Nrf2 could be transferred to the nucleus and initiated in the downstream pathway, thus playing an anti‐oxidant stress role 38,39 . We found that inhibition of NRF2 expression downregulated CYLD‐AS1, indicating that NRF2 is located upstream of CYLD‐AS1.…”

Section: Discussionmentioning

confidence: 76%

“…37 When activated, Nrf2 could be transferred to the nucleus and initiated in the downstream pathway, thus playing an anti-oxidant stress role. 38,39 We found that inhibition of NRF2 expression downregulated CYLD-AS1, indicating that NRF2 is located upstream of CYLD-AS1. ROS were also found to act upstream of CYLD-AS1.…”

Section: Discussionmentioning

confidence: 83%