A Multiantioxidant Supplementation Reduces Damage from Ischaemia Reperfusion in Patients after Lower Torso Ischaemia. A Randomised Trial

Wijnen, M.H.W.A.; Roumen, R. M. H.; Vader, Huib L.; Goris, R.J.A.

doi:10.1053/ejvs.2002.1614

Cited by 38 publications

(27 citation statements)

References 32 publications

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“…Histopathologic and antiinfl ammatory effects of the peptid should also be investigated. The regulator and angiogenetic effects of VEGF have been suggested in previous studies (7,10,28). We have hypothesized that it may also have an antioxidative effect on lung injury to some extent.…”

Section: Discussionmentioning

confidence: 79%

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Antioxidative effects of adrenomedullin and vascular endothelial growth factor on lung injury induced by skeletal muscle ischemia-reperfusion

Gl¹,

Kirişçi²,

Dursun³

et al. 2013

BLL

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Abstract:Purpose: The aim of this study was to investigate the effects of adrenomedullin (AM) and vascular endothelial growth factor (VEGF) on lung injury as a remote organ following skeletal muscle ischemia-reperfusion injury in a rat model. Materials and methods: Thirty-six Wistar rats were randomized into six groups (n=6). Laparotomy was performed in all groups under general anesthesia. Nothing else was done in Group S (Sham). Ischemia reperfusion group (Group I/R) underwent ischemia and reperfusion performed by clamping and declamping of the infrarenal abdominal aorta for 120 minutes, respectively. Group VEGF and Group AM received intravenous infusion of VEGF (0.8 μg/kg) or AM (12 μg /kg) respectively, without ischemia and reperfusion. Group IR+VEGF and Group IR+AM received intravenous infusion of VEGF (0.8 μg/kg) or AM (12 μg /kg) respectively immediately after 2 hours period of ischemia. At the end of reperfusion period. Lung tissue samples were taken for biochemical examination. Total oxidant status (TOS) and total antioxidant status (TAS) levels in lung tissue were determined by using a novel automated method. p<0.05 was considered as statistically signifi cant. Results: TOS levels were signifi cantly higher in Group I/R, when compared with groups S, AM and VEGF (p=0.004, p=0.011, p=0.017, respectively) and signifi cantly lower in groups I/R+AM and I/R+VEGF, when compared with Group I/R (p=0.018, p=0.006, respectively). TAS levels were signifi cantly higher in Group I/R, when compared with groups S, AM and VEGF (p=0.006 p=0.016, p=0.016, respectively) and signifi cantly lower in Group I/R+AM, when compared with Group I/R (p=0.016). Conclusion: These fi ndings indicate that AM and VEGF acted effectively on the prevention of lung injury induced by skeletal muscle ischemia-reperfusion injury in a rat model (Fig. 2, Ref. 30). Full Text in PDF www.elis.sk.

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Section: Discussionmentioning

confidence: 79%

“…Widespread distribution of VEGF and its specifi c receptors in the vasculature implies an important role for VEGF in maintenance of normal vascular function and development (8). It has been demonstrated that VEGF stimulates nitric oxide release from vascular endothelial cells (9,10).…”

mentioning

confidence: 99%

Antioxidative effects of adrenomedullin and vascular endothelial growth factor on lung injury induced by skeletal muscle ischemia-reperfusion

Gl¹,

Kirişçi²,

Dursun³

et al. 2013

BLL

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“…In contrast to the results of Lassnigg et al [17] in cardiac surgery, Wijnen et al[ 25] found a decrease in serum levels of creatine kinase, aspartate aminotransferase and lipofuscine levels in individuals undergoing infrarenal AAA repair who received preoperative supplementation with multiple antioxidants (vitamins E and C, allopurinol, NAC and mannitol). In this small (n = 42) prospective randomized trial, they did not examine renal biomarkers or AKI, and the exact mechanism that led to the decrease in the oxidant stress biomarkers is unclear.…”

Section: Oxidant Mechanismmentioning

confidence: 81%

Antioxidants

Koyner

Ali

Murray

2008

Nephron Exp Nephrol

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Over the past several years, advances in our understanding of the pathogenesis of acute kidney injury (AKI) have demonstrated the role of oxidant stress and reactive oxygen metabolites (ROM) in the development of AKI in a variety of clinical settings. This review serves to define the pathways that lead to the generation of ROM following a variety of insults, as well as to review the current literature concerning the role of antioxidant therapy in the prevention and treatment of AKI in several clinical settings. Investigators have explored the potential therapeutic role of anti-oxidants in both experimental animal models and human studies of AKI in several clinical settings, including cardiac and aortic occlusive surgeries, sepsis, drug nephrotoxicity (cisplatin and gentamicin), as well as rhabdomyolysis. While the experimental animal studies have generally been more successful, taken together this literature supports the hypothesis that oxidant stress-induced production of ROM plays a major role in the pathogenesis of many forms of AKI, and continues to suggest the potential utility of antioxidant therapy in human AKI. Ongoing trials in concert with improved diagnostic techniques will hopefully lead to improved outcomes in the setting of AKI through the prophylactic or early therapeutic use of antioxidant therapy.

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“…Winjen e col., demonstraram que a utilização de cinco antioxidantes reduziu a incidência de IRA em pacientes submetidos à correção de aneurisma de aorta abdominal 39 .…”

Section: Bloqueadores Da Resposta Inflamatóriaunclassified

Proteção renal na unidade de terapia intensiva cirúrgica

Santos¹,

Hajjar²,

Galas³

et al. 2006

Rev. bras. ter. intensiva

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RESUMO JUSTIFICATIVA E OBJETIVOS:A disfunção renal perioperatória é importante causa de aumento de morbimortalidade. Com o aumento da expectativa de vida, pacientes mais idosos e com maior números de co-morbidades estão sendo submetidos à procedimentos cirúrgicos de alto risco, o que torna as práticas da proteção orgânica possíveis modificadoras de prognóstico a curto e longo prazo. Nesse contexto, esta revisão sobre a proteção renal na unidade de terapia intensiva cirúrgica objetivou destacar os fatores de riscos peri-operatórios e discutir as atuais evidências científicas direcionadas para a diminuição da disfunção renal peri-operatória. CONTEÚDO: Apesar da baixa extração e adequada reserva renal de oxigênio, o rim é extremamente sensível

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A Multiantioxidant Supplementation Reduces Damage from Ischaemia Reperfusion in Patients after Lower Torso Ischaemia. A Randomised Trial

Abstract: multi-antioxidant supplementation was associated with a reduction in serum CK and ASAT after AAA repair. This is likely due to a reduction in oxidative stress and a decreased leucocyte sequestration and activation.

Cited by 38 publications

References 32 publications

Antioxidative effects of adrenomedullin and vascular endothelial growth factor on lung injury induced by skeletal muscle ischemia-reperfusion

Antioxidative effects of adrenomedullin and vascular endothelial growth factor on lung injury induced by skeletal muscle ischemia-reperfusion

Antioxidants

Proteção renal na unidade de terapia intensiva cirúrgica

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