A multicenter cohort study of severe dengue and critically ill influenza patients with elevated cardiac troponin-I: Difference clinical features and high mortality

Lee, Ing-Kit; Chen, Yen-Hsu; Huang, Chung‐Hao; Hsu, Jui-Chi; Chang, Yi-Chin; Kuo, Hong-Jie; Tai, Chien-Hsiang; Lee, Nan-Yao

doi:10.1016/j.tmaid.2022.102281

Cited by 7 publications

(7 citation statements)

References 41 publications

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“…Of the 4209 publications identified using the search strategies described above, 42 articles were selected after meeting the inclusion criteria. The verification of cited articles and citation of included articles yielded nine relevant observational, prospective, and retrospective descriptive studies [41][42][43][44][45][46][47][48][49]. The study selection flowchart for the different phases of the systematic review is displayed in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

Heart Disease and Arboviruses: A Systematic Review and Meta-Analysis

Nicacio

Gomes

Carmo

et al. 2022

Viruses

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Dengue fever, chikungunya, and zika are highly prevalent arboviruses transmitted by hematophagous arthropods, with a widely neglected impact in developing countries. These diseases cause acute illness in diverse populations, as well as potential cardiovascular complications. A systematic review was carried out to investigate the burden of cardiac involvement related to these arboviruses. Multiple databases were searched for articles that investigated the association of cardiovascular diseases with arboviruses, published up to March 2022. Relevant articles were selected and rated by two independent reviewers. Proportion meta-analysis was applied to assess the frequency-weighted mean of the cardiovascular findings. A total of 42 articles were selected (n = 76,678 individuals), with 17 manuscripts on dengue and 6 manuscripts on chikungunya undergoing meta-analysis. The global pooled incidence of cardiac events in dengue fever using a meta-analysis was 27.21% (95% CI 20.21–34.83; I2 = 94%). The higher incidence of dengue-related myocarditis was found in the population younger than 20 years old (33.85%; 95% CI 0.00–89.20; I2 = 99%). Considering the studies on chikungunya (n = 372), the global pooled incidence of cardiac involvement using a meta-analysis was 32.81% (95% CI 09.58–61.49, I2 = 96%). Two Zika studies were included that examined cases of infection by vertical transmission in Brazil, finding everything from structural changes to changes in heart rate variability that increase the risk of sudden death. In conclusion, cardiac involvement in arboviruses is not uncommon, especially in dengue fever.

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Section: Resultsmentioning

confidence: 99%

Heart Disease and Arboviruses: A Systematic Review and Meta-Analysis

Nicacio

Gomes

Carmo

et al. 2022

Viruses

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“…As a vasoconstrictor, 5-HT has been widely involved in physiological processes such as vascular function, hemostasis, liver regeneration, intestinal motility, insulin secretion, immune response, and so on. Some scholars have found in animal medical research that the abnormal expression of 5-HT in sepsis mice is one of the important risk factors leading to the decline of cardiac function [ 6 ]. As an intermediate product of glucose aerobic metabolism, lactate (Lac) can be significantly increased in oxygenation disorders and glucose anaerobic glycolysis.…”

Section: Introductionmentioning

confidence: 99%

[Retracted] Analysis of the Predictive Effect of Lactic Acid Combined with Cardiac Troponin T and 5‐Hydroxytryptophan on the Severity of Sepsis in ICU Patients and Its Correlation with Prognosis

Jiang

Wang

et al. 2022

Contrast Media & Molecular Imaging

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In order to explore the effective markers of presepsis in the prediction of clinical disease and disease severity, the predictive effect of lactic acid (Lac) combined with cardiac troponin T (cTnT) and 5-hydroxytryptophan (5-HT) on the severity of sepsis in intensive care unit (ICU) patients and its correlation with prognosis is investigated. A total of 85 sepsis patients admitted to the ICU of our hospital from January 2020 to June 2021 are selected to establish the ICU sepsis group, and 72 health examination patients who received physical examination in our hospital during the same period are included in the healthy control group. The experimental results demonstrate that combined detection mode of serum Lac, cTnT, and 5-HT indicators has a high predictive value for the condition of patients with ICU sepsis and those indicators are closely correlated with the prognosis of patients. It suggests that the follow-up clinical monitoring of serum Lac, cTnT, and 5-HT indicators for patients with ICU sepsis can evaluate their condition and improve and optimize the clinical diagnosis and treatment plan effectively.

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“…In cohort and cross sectional studies in which the main inclusion criterion was acute dengue infection, with no restriction on severity or on AST and/or ALT elevation, ALF defined as AST and/or ALT >1000 IU/L occurred in 0.4%–36.4% of dengue cases 27,47,48,50,53,70,71,73,81,88 (Figure 2c) and in 53.6%–71% of dengue‐related deaths 66,89,90 . Thirteen articles described fulminant liver failure in a total of 42 patients 6,72,91–101 (Figure 2c). Hepatic encephalopathy was observed in 15 studies 54,56,65,84,91,96,99,102–109 (Figure 2c).…”

Section: Resultsmentioning

confidence: 99%

“…The composite index AST 2 / ALT, calculated at admission as the square of the AST level divided by the ALT level, was a reliable predictor of severe dengue, with an optimal cut-off value at 402.5. 47 AST and/or ALT levels were significantly higher 33,38,60,70,72,75,82,134 and ALF more common 82 in patients with a fatal outcome, severe hepatitis (AST≥1000 IU/L) being an independent predictor of mortality. 60,70,128 Bleeding had a higher incidence in patients with elevated liver enzymes.…”

Section: Dengue-associated Liver Involvement Correlates With Dengue S...mentioning

confidence: 94%

Liver involvement in dengue: A systematic review

Campana,

Inizan,

Pommier

et al. 2024

Reviews in Medical Virology

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Liver involvement is an unusual yet frequently overlooked dengue complication. Pivotal for an efficient clinical management, the early diagnosis of dengue‐associated liver involvement relies on an accurate description of its clinical and biological characteristics, its prognosis factors, its association with severe dengue and its clinical management. We conducted a systematic review by searching PubMed and Web of Science databases for original case reports, cohort and cross‐sectional studies reporting the clinical and/or biological features of dengue‐associated liver involvement. The study was registered in PROSPERO (CRD42021262657). Of the 2552 articles identified, 167 were included. Dengue‐associated liver involvement was characterised by clinical features including abdominal pain, hepatomegaly, jaundice, nausea/vomiting, and an echogenic liver exhibiting hepatocellular necrosis and minimal inflammation. Elevated Aspartate Aminotransferase and Alanine Aminotransferase but also elevated bilirubin, Alkaline Phosphatase, gamma‐glutamyl transferase, increased International Normalised Ratio, creatinine and creatine kinase, lower albumin and prolonged prothrombin and activated partial thromboplastin time were prevalent in dengue‐associated liver involvement. Cardiovascular and haematological systems were frequently affected, translating in a strong association with severe dengue. Liver involvement was more common in males and older adults. It was associated with dengue virus serotype‐2 and secondary infections. Early paracetamol intake increased the risk of liver involvement, which clinical management was mostly conservative. In conclusion, this systematic review demonstrates that early monitoring of transaminases, clinical assessment, and ultrasound examination allow an efficient diagnosis of dengue‐associated liver involvement, enabling the early identification and management of severe dengue.

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A multicenter cohort study of severe dengue and critically ill influenza patients with elevated cardiac troponin-I: Difference clinical features and high mortality

Cited by 7 publications

References 41 publications

Heart Disease and Arboviruses: A Systematic Review and Meta-Analysis

Heart Disease and Arboviruses: A Systematic Review and Meta-Analysis

[Retracted] Analysis of the Predictive Effect of Lactic Acid Combined with Cardiac Troponin T and 5‐Hydroxytryptophan on the Severity of Sepsis in ICU Patients and Its Correlation with Prognosis

Liver involvement in dengue: A systematic review

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