A multicenter study investigating the molecular fingerprint of psychological resilience in breast cancer patients: study protocol of the SCAN-B resilience study

Abstract

BackgroundIndividual patients differ in their psychological response when receiving a cancer diagnosis, in this case breast cancer. Given the same disease burden, some patients master the situation well, while others experience a great deal of stress, depression and lowered quality of life. Patients with high psychological resilience are likely to experience fewer stress reactions and better adapt to and manage the life threat and the demanding treatment that follows the diagnosis. If this phenomenon of mastering difficult situations is reflected also in biomolecular processes is not much studied, nor has its capacity for impacting the cancer prognosis been addressed.This project specifically aims, for the first time, to investigate how a breast cancer patient’s psychological resilience is coupled to biomolecular parameters using advanced “omics” and, as a secondary aim, whether it relates to prognosis and quality of life one year after diagnosis.MethodThe study population consists of newly diagnosed breast cancer patients enrolled in the Sweden Cancerome Analysis Network – Breast (SCAN-B) at four hospitals in Sweden. At the time of cancer diagnosis, the patient fills out the standardized method to measure psychological resilience, the “Connor-Davidson Resilience scale” (CD-RISC), the quality of life measure SF-36, as well as providing social and socioeconomic variables. In addition, one blood sample is collected. At the one-year follow-up, the patient will be subjected to the same assessments, and we also collect information regarding smoking, exercise habits, and BMI, as well as patients’ trust in the treatment and their satisfaction with the care and treatment.DiscussionThis explorative hypothesis-generating project will pave the way for larger validation studies, potentially leading to a standardized method of measuring psychological resilience as an important parameter in cancer care. Revealing the body-mind interaction, in terms of psychological resilience and quality of life, will herald the development of truly personalized psychosocial care and cancer intervention treatment strategies.Trial registrationThis is a retrospectively registered trial at ClinicalTrials.gov, ID: NCT03430492 on February 6, 2018.Electronic supplementary materialThe online version of this article (10.1186/s12885-018-4669-y) contains supplementary material, which is available to authorized users.

<p>Psychological Resilience and Health-Related Quality of Life in Swedish Women with Newly Diagnosed Breast Cancer</p>

“…This cross-sectional study was conducted within the greater prospective study SCAN-B Resilience (NCT03430492) 7 as part of the Sweden Cancerome Analysis Network – Breast (SCAN-B) initiative. 23 The inclusion criteria for SCAN-B Resilience have been stated in the published study protocol.…”

“…[2][3][4][5][6] There has been a growing interest in determining the psychological factors that may enhance HRQoL in BC patients. [4][5][6][7] Psychological resilience, defined as the capacity to cope successfully with external stress, eg, a diagnosis of cancer, has been described as the most important protective factor associated with HRQoL in BC patients. 4,6,[8][9][10][11] Higher levels of psychological resilience do not make the patients unaffected by distress, but they do help the patients to adapt when facing significant adversities.…”

Psychological resilience and health-related quality of life in Swedish women with newly diagnosed breast cancer

“…This cross-sectional study was conducted within the greater prospective study SCAN-B Resilience [7] (NCT03430492) as part of the Sweden Cancerome Analysis Network-Breast (SCAN-B) initiative [22].…”

“…There has been a growing interest in determining the psychosocial factors that may enhance HRQoL in BC patients [4][5][6][7], and the positive impact of a supportive social network has been reported [8].…”

Nursing research: A success story or what next?

“…For instance a large data base on women contracting and being treated for breast cancer (Sweden Cancerome Analysis Network -Breast. www.scan.bmc.lu.se) now has a sub-database exploring the relationship between biomolecular variables and psychological resilience, quality of life, social network and trust in health care/treatment (10). This is thus an attempt to broaden and make use of the biomedical data already collected by integrating nursing and psychological research.…”