A multicentre study of oral paracoccidioidomycosis: Analysis of 320 cases and literature review

Abstract

Oral paracoccidioidomycosis is an uncommon lesion observed in oral biopsy samples. The differences in the relative frequency of oral paracoccidioidomycosis are related to geographical variations. Men between 50 and 59 years are more affected. This study provides helpful information for clinicians in the diagnosis of oral paracoccidioidomycosis.

Different DNA methylation profile is demonstrated in paracoccidioidomycosis patients without oral lesions

“…PCM is a leading cause of death from chronic infectious in Brazil, affecting mainly rural workers with mean age of 47 years . Due to the absence of compulsory notification in our country, the accessibility of data about the oral manifestation of PCM is still limited . Interestingly, the oral manifestation of the chronic PCM does not occur in all patients; some authors reported oral involvement in 50% of cases, rising involvement of this site in agreement with patients’ age .…”

“…7,34 Due to the absence of compulsory notification in our country, the accessibility of data about the oral manifestation of PCM is still limited. 9,35 Interestingly, the oral manifestation of the chronic PCM does not occur in all patients 36 ; some authors reported oral involvement in 50% of cases, rising involvement of this site in agreement with patients' age. 37 Nevertheless, there are a few findings capable of explaining the absence of oral lesions in some chronic PCM patients.…”

Oral paracoccidioidomycosis affecting the buccal mucosa

“…introduction Paracoccidioidomycosis (PCM), also known as South American blastomycosis, is a tropical disease caused by the dimorphic fungus Paracoccidioides brasiliensis, initially described by Adolfo Lutz in 1908 1,2 . Although a rare disorder from a global perspective, the disease is endemic in Latin America and is estimated to infect about 10 million Latin Americans.…”

“…Although a rare disorder from a global perspective, the disease is endemic in Latin America and is estimated to infect about 10 million Latin Americans. In Brazil, PCM is the main cause of death by systemic mycosis, and the eighth cause among infectious diseases 1,3 , with an estimated incidence of approximately 1 to 3.7 cases per million individuals annually 1 . PMC more commonly affects farm workers and/or people who live in rural areas, particularly males, smokers and/or chronic alcoholics, aged between 30 and 50 years 2,3 .…”

“…Although the primary route of PCM infection is pulmonary, the disease is often diagnosed by oral manifestations 4 . Oral mucosal lesions may be the first visible clinical manifestation of the disease, often even preceding lung lesions 1 . The oral cavity may be affected at one or multiple sites, with the gingiva/alveolar ridge and palate being the most frequent anatomical sites 1,2 .…”