A multifaceted approach for management of prediabetes and its associated cardiovascular risk

Rifai, Mahmoud Al; Shapiro, Michael D.

doi:10.1002/dmrr.3314

Cited by 2 publications

(2 citation statements)

References 16 publications

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“…Pre-diabetes is a hyperglycemic state between normal blood glucose and diabetes ( Association, 2020 ), including impaired fasting blood glucose (IFG) and/or impaired glucose tolerance (IGT), which is an important stage in the occurrence and development of diabetes. Previous studies have shown that pre-diabetes ( Al Rifai and Shapiro, 2020 )is associated with the risk of all-cause mortality, cardiovascular and cerebrovascular diseases, and heart failure. Pre-diabetes is reversible, and lifestyle intervention can delay the progression from pre-diabetes to diabetes ( Khan et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Glucolipid metabolism improvement in impaired glucose tolerance subjects consuming a Quinoa-based diet: a randomized parallel clinical trial

et al. 2023

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Purpose: To investigate the effects of quinoa on glucose and lipid metabolism, and the prognosis in people with impaired glucose tolerance.Methods: One hundred and thirty-eight patients diagnosed with impaired glucose tolerance following a glucose tolerance test in Guangzhou Cadre Health Management Center were selected and randomly divided into quinoa intervention and control groups, according to the digital table method. After 1 year of follow-up, the differences in blood glucose, blood lipid, glycosylated hemoglobin and other indicators were compared. The disease prognosis between the two groups was also compared.Results: The 2 h postprandial blood glucose, glycosylated hemoglobin, insulin resistance index, total cholesterol, low-density lipoprotein cholesterol, body mass index, waist circumference, systolic and diastolic blood pressure after intervention in the quinoa group were significantly lower than before intervention. In contrast, high-density lipoprotein cholesterol was higher than before intervention and is statistically significant (p < 0.05). After 1 year of follow-up, the control group’s glycosylated hemoglobin and body mass index are higher than before intervention, and are statistically significant (p < 0.05). The 2 h postprandial blood glucose, glycosylated hemoglobin, insulin resistance index, body mass index, and mean diastolic blood pressure in the quinoa group are statistically significantly lower than in the control group, while high-density lipoprotein cholesterol is higher (p < 0.05). The rate of conversion to diabetes for participants in the quinoa group (7.8%) is statistically significantly lower than in the control group (20.3%) (χ2 = 12.760, p = 0.002). Logistic regression analysis showed that quinoa consumption is a protective factor against delaying the progression of diabetes (p < 0.05).Conclusion: Adding quinoa to staple food intake can reduce postprandial blood glucose, and improve lipid metabolism and insulin resistance, delaying the progression of diabetes in people with impaired glucose tolerance.

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Section: Introductionmentioning

confidence: 99%

Glucolipid metabolism improvement in impaired glucose tolerance subjects consuming a Quinoa-based diet: a randomized parallel clinical trial

et al. 2023

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“…There is a 9%–25% increase of prediabetes converting into T2D with a haemoglobin A1c (HbA1c) between 5.5% and 6.0% and a 25%–50% increase with an HbA1c between 6.0% and 6.5% over a 5‐year time period 3,4 . These individuals also have a higher risk of heart failure and stroke 5 …”

Section: Introductionmentioning

confidence: 99%

An increase in inflammation and islet dysfunction is a feature of prediabetes

Weaver

Odanga

Breathwaite

et al. 2020

Diabetes Metabolism Res

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Aims Type 2 diabetes (T2D) is a global health problem that will be diagnosed in almost 300 million people by 2025 according to the World Health Organization. Before being diagnosed with T2D, individuals may have glucose levels above normal but below the diabetic range. This condition is known as prediabetes. Studies showed that people with prediabetes had an increase in several pro‐inflammatory cytokines in their serum and in their fasting glucose levels. The answer remains unclear when inflammation begins in the pancreas and islets, and what is the extent of this inflammation. Methods Subjects with haemoglobin A1c levels from 5.7% to 6.4% were classified as pre‐diabetic. Sections of pancreas and isolated islets from normal donors and donors with prediabetes were tested for markers of inflammation and glucose‐stimulated insulin secretion (GSIS). Results Gene and protein expression of the inflammatory markers resistin, interleukin‐1 beta, tumour necrosis factor‐alpha, interleukin‐6, and monocyte chemoattractant protein‐1 increased in donors with prediabetes compared to normal donors. GSIS response was significantly decreased in pre‐diabetic islets compared to normal islets. Donors with prediabetes also had decreased expression of CD163+ cells but not CD68+ cells. Conclusions Based on our findings, inflammation and islet dysfunction may be more significant than originally thought in people with prediabetes. Rather than being in a normal state before diabetes occurs, it appears that subjects are already in an early diabetic condition resembling more closely T2D.

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A multifaceted approach for management of prediabetes and its associated cardiovascular risk

Cited by 2 publications

References 16 publications

Glucolipid metabolism improvement in impaired glucose tolerance subjects consuming a Quinoa-based diet: a randomized parallel clinical trial

Glucolipid metabolism improvement in impaired glucose tolerance subjects consuming a Quinoa-based diet: a randomized parallel clinical trial

An increase in inflammation and islet dysfunction is a feature of prediabetes

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