Abstract:Treatments for infectious bone defects such as periodontitis require antibacterial and osteogenic differentiation capabilities. Nanotechnology has prompted the development of multifunctional material. In this research, we aim to synthesize a nanoparticle that can eliminate periodontal pathogenic microorganisms and simultaneously stimulate new bone tissue regeneration and mineralization. QAS-modified core-shell mesoporous silica containing Ag nanoparticles (Ag@QHMS) was successfully synthesized through the clas… Show more
“… 114 Furthermore, a type of mesoporous silica-containing AgNPs was introduced by Li et al as a novel antimicrobial and osteogenic medicine that eliminates periodontal pathogenic microorganisms and stimulates bone tissue regeneration simultaneously ( Figure 7 ). 115 Figure 7 Applications of mesoporous silica containing AgNPs in periodontics. ( A ) Synthesis procedure of QAS-modified core-shell mesoporous silica containing Ag nanoparticles (Ag@QHMS).…”
Section: Antimicrobial Agbms Incorporated In Dental Materialsmentioning
Microbial infection accounts for many dental diseases and treatment failure. Therefore, the antibacterial properties of dental biomaterials are of great importance to the long-term results of treatment. Silver-based biomaterials (AgBMs) have been widely researched as antimicrobial materials with high efficiency and relatively low toxicity. AgBMs have a broad spectrum of antimicrobial properties, including penetration of microbial cell membranes, damage to genetic material, contact killing, and dysfunction of bacterial proteins and enzymes. In particular, advances in nanotechnology have improved the application value of AgBMs. Hence, in many subspecialties of dentistry, AgBMs have been researched and employed, such as caries arresting or prevention, root canal sterilization, periodontal plaque inhibition, additives in dentures, coating of implants and anti-inflammatory material in oral and maxillofacial surgery. This paper aims to provide an overview of the application approaches of AgBMs in dentistry and present better guidance for oral antimicrobial therapy via the development of AgBMs.
“… 114 Furthermore, a type of mesoporous silica-containing AgNPs was introduced by Li et al as a novel antimicrobial and osteogenic medicine that eliminates periodontal pathogenic microorganisms and stimulates bone tissue regeneration simultaneously ( Figure 7 ). 115 Figure 7 Applications of mesoporous silica containing AgNPs in periodontics. ( A ) Synthesis procedure of QAS-modified core-shell mesoporous silica containing Ag nanoparticles (Ag@QHMS).…”
Section: Antimicrobial Agbms Incorporated In Dental Materialsmentioning
Microbial infection accounts for many dental diseases and treatment failure. Therefore, the antibacterial properties of dental biomaterials are of great importance to the long-term results of treatment. Silver-based biomaterials (AgBMs) have been widely researched as antimicrobial materials with high efficiency and relatively low toxicity. AgBMs have a broad spectrum of antimicrobial properties, including penetration of microbial cell membranes, damage to genetic material, contact killing, and dysfunction of bacterial proteins and enzymes. In particular, advances in nanotechnology have improved the application value of AgBMs. Hence, in many subspecialties of dentistry, AgBMs have been researched and employed, such as caries arresting or prevention, root canal sterilization, periodontal plaque inhibition, additives in dentures, coating of implants and anti-inflammatory material in oral and maxillofacial surgery. This paper aims to provide an overview of the application approaches of AgBMs in dentistry and present better guidance for oral antimicrobial therapy via the development of AgBMs.
“…In addition to the improvement of the delivery scaffolds for suitable growth factors, MSNs have also been applied to stimulate osteogenic [ 183 , 184 , 185 , 186 , 187 ], myogenic [ 188 , 189 ], and angiogenic differentiation of bone mesenchymal stem cells (BMSCs). For example, Shi et al used dimethyloxalylglycine-loaded MSNs (D-MSNs) with a uniform sphere size of ~90 nm and mesopores of ~2.7 nm [ 190 ].…”
Section: Update On Msn Applications In Nanomedicinesmentioning
The efficient and safe delivery of therapeutic drugs, proteins, and nucleic acids are essential for meaningful therapeutic benefits. The field of nanomedicine shows promising implications in the development of therapeutics by delivering diagnostic and therapeutic compounds. Nanomedicine development has led to significant advances in the design and engineering of nanocarrier systems with supra-molecular structures. Smart mesoporous silica nanoparticles (MSNs), with excellent biocompatibility, tunable physicochemical properties, and site-specific functionalization, offer efficient and high loading capacity as well as robust and targeted delivery of a variety of payloads in a controlled fashion. Such unique nanocarriers should have great potential for challenging biomedical applications, such as tissue engineering, bioimaging techniques, stem cell research, and cancer therapies. However, in vivo applications of these nanocarriers should be further validated before clinical translation. To this end, this review begins with a brief introduction of MSNs properties, targeted drug delivery, and controlled release with a particular emphasis on their most recent diagnostic and therapeutic applications.
“…In these systems, antibacterial components are not only antibiotics [51,54], but also metal nanoparticles such as silver [11,[23][24][25][26][27][28][29][30][31][34][35][36][37][38][39]43,44,46,52,53,57,58] and polymer nanoparticles such as CS (nCS) [53]. Osteogenic components include drugs such as lovastatin and minocycline [51,54], metal nanoparticles such as silver and calcium [52,59], and polymer nanoparticles such as poly(lactic-co-glycolic acid) (nPLGA) and nCS [53], etc. Different ratios of active ingredients produce different effects.…”
Periodontitis is a chronic infectious disease that destroys periodontal supportive tissues and eventually causes tooth loss. It is attributed to microbial and immune factors. The goal of periodontal therapy is to achieve complete alveolar bone regeneration while keeping inflammation well-controlled. To reach this goal, many single or composite biomaterials that produce antibacterial and osteogenic effects on periodontal tissues have been developed, which are called bifunctional biomaterials. In this review, we summarize recent progress in periodontal bifunctional biomaterials including bioactive agents, guided tissue regeneration/guided bone regeneration (GTR/GBR) membranes, tissue engineering scaffolds and drug delivery systems and provide novel perspectives. In conclusion, composite biomaterials have been greatly developed and they should be chosen with care due to the risk of selection bias and the lack of evaluation of the validity of the included studies.
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