A Multifunctional Bimetallic Nanoplatform for Synergic Local Hyperthermia and Chemotherapy Targeting HER2‐Positive Breast Cancer

Zhao, Li; Chang, Fei; Tong, Yao; Yin, Jiawei; Xu, Jiawen; Li, Hui; Du, Lutao; Jiang, Yanyan

doi:10.1002/advs.202308316

Cited by 11 publications

(2 citation statements)

References 38 publications

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“…The absorbance was measured at 562 nm. The LE of Gox was calculated according to the standard curves and based on the formulation LE .25em ( % ) = amount .25em of .25em Gox .25em in .25em the .25em nanoparticle / amount .25em of .25em nanoparticle × 100 % EE .25em ( % ) = amount .25em of .25em Gox .25em in .25em the .25em nanoparticle / total .25em amount .25em of .25em Gox × 100 % …”

Section: Experimental Sectionmentioning

confidence: 99%

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Mito-Specific Nutri-Hijacker Synergizing Mitochondrial Metabolism and Glycolysis Intervention for Enhanced Antitumor Bioenergetic Therapy

Yang,

Chu,

Zhang

et al. 2024

ACS Appl. Mater. Interfaces

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Metabolic rewiring, a dynamic metabolic phenotype switch, confers that tumors exist and proliferate after fitness (or preadaptation) in harsh environmental conditions. Glycolysis deprivation was considered to be a tumor’s metabolic Achilles heel. However, metabolic configuration can flexibly retune the mitochondrial metabolic ability when glycolysis is scared, potentially resulting in more aggressive clones. To address the challenge of mitochondrial reprogramming, an antiglycolytic nanoparticle (GRPP NP) containing a novel mitochondrial-targeted reactive oxygen species (ROS) generator (diIR780) was prepared to hijack glucose and regulate mitochondria, thus completely eliminating tumorigenic energy sources. In this process, GRPP NPs@diIR780 can catalyze endogenous glucose, leading to significantly suppressed glycolysis. Moreover, diIR780 can be released and selectively accumulated around mitochondria to generate toxic ROS. These combined effects, in turn, can hamper mitochondrial metabolism pathways, which are crucial for driving tumor progression. This synchronous intervention strategy enables utter devastation of metabolic rewiring, providing a promising regiment to eradicate tumor lesions without recurrence.

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Section: Experimental Sectionmentioning

confidence: 99%

“…The absorbance was measured at 562 nm. The LE of Gox was calculated according to the standard curves and based on the formulation …”

Section: Experimental Sectionmentioning

confidence: 99%

Mito-Specific Nutri-Hijacker Synergizing Mitochondrial Metabolism and Glycolysis Intervention for Enhanced Antitumor Bioenergetic Therapy

Yang,

Chu,

Zhang

et al. 2024

ACS Appl. Mater. Interfaces

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Atomic‐Thin 2D Copper Sulfide Nanocrystals with over 94% Photothermal Conversion Efficiency as Superior NIR‐II Photoacoustic Agents

Su,

Wu,

Yan

et al. 2024

Adv Funct Materials

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Exploring photothermal nanomaterials is essential for new energy and biomedical applications; however, preparing materials with intense absorption, highly efficient light‐to‐heat conversion, and enhanced photostability still faces the enduring challenge. Herein, the study synthesizes atomic‐thin (≈1.6 nm) 2D copper sulfide (AT‐CuS) plasmonic nanocrystals and find its extraordinary photothermal conversion efficiency (PCE) reaching up to 94.3% at the second near‐infrared (NIR‐II) window. Photophysical mechanism studies reveal that the strong localized surface plasmon resonance (LSPR) and out‐of‐plane size effect of AT‐CuS induce strong optical absorption and non‐equilibrium carrier scattering, resulting in a significant carrier‐phonon coupling (7.18 × 1017 J K−1 s−1 m−3), ultimately enhancing the heat generation. Such a photothermal nanomaterial demonstrates at leastmes stronger NIR‐II photoacoustic (PA) signal intensity than that of most commonly used miniature gold nanorods, together with greater biocompatibility and photo‐/thermal‐stability, enabling noninvasive PA imaging of brain microvascular in living animals. This work provides an insight into the rational exploration of superb NIR‐II photothermal and photoacoustic agents for future practical utilizations.

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Photoresponsive Multirole Nanoweapon Camouflaged by Hybrid Cell Membrane Vesicles for Efficient Antibacterial Therapy of Pseudomonas aeruginosa‐Infected Pneumonia and Wound

Liu,

Tang,

Yin

et al. 2024

Advanced Science

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Exploring effective antibacterial approaches for targeted treatment of pathogenic bacterial infections with reduced drug resistance is of great significance. Combinational treatment modality that leverages different therapeutic components can improve the overall effectiveness and minimize adverse effects, thus displaying considerable potential against bacterial infections. Herein, red blood cell membrane fuses with macrophage membrane to develop hybrid cell membrane shell, which further camouflages around drug‐loaded liposome to fabricate biomimetic liposome (AB@LRM) for precise antibacterial therapy. Specifically, photoactive agent black phosphorus quantum dots (BPQDs) and classical antibiotics amikacin (AM) are loaded in AB@LRM to accurately target the inflammatory sites through the guidance of macrophage membrane and long residence capability of red blood cell membrane, eventually exerting efficacious antibacterial activities. Besides, due to the excellent photothermal and photodynamic properties, BPQDs act as an efficient antibacterial agent when exposed to near‐infrared laser irradiation, dramatically increasing the sensitivity of bacteria to antibiotics. Consequently, the synergistic sterilizing effect produced by AB@LRM further restricts bacterial resistance. Upon laser irradiation, AB@LRM shows superior anti‐inflammatory and antibacterial properties in models of P. aeruginosa‐infected pneumonia and wounds. Hence, this light‐activatable antibacterial nanoplatform with good biocompatibility presents great potential to advance the clinical development in the treatment of bacterial infections.

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A Multifunctional Bimetallic Nanoplatform for Synergic Local Hyperthermia and Chemotherapy Targeting HER2‐Positive Breast Cancer

Cited by 11 publications

References 38 publications

Mito-Specific Nutri-Hijacker Synergizing Mitochondrial Metabolism and Glycolysis Intervention for Enhanced Antitumor Bioenergetic Therapy

Mito-Specific Nutri-Hijacker Synergizing Mitochondrial Metabolism and Glycolysis Intervention for Enhanced Antitumor Bioenergetic Therapy

Atomic‐Thin 2D Copper Sulfide Nanocrystals with over 94% Photothermal Conversion Efficiency as Superior NIR‐II Photoacoustic Agents

Photoresponsive Multirole Nanoweapon Camouflaged by Hybrid Cell Membrane Vesicles for Efficient Antibacterial Therapy of Pseudomonas aeruginosa‐Infected Pneumonia and Wound

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