A multifunctional cholesterol-free liposomal platform based on protopanaxadiol for alopecia therapy

Self-assembled nanodrug delivery systems for anti-cancer drugs from traditional Chinese medicine

“…Replacing cholesterol synthesized in liposomes with ginsenoside compounds can obviate some of the inherent dangers of liposome delivery systems, such as hyperlipidemia, pulmonary hypertension, and other diseases caused by excessive cholesterol absorption. 204,205 Therefore, liposome delivery systems based on GS provide expanded possibilities for the delivery of liposome drugs for chronic diseases. Wang and colleagues conducted a detailed study of a ginsenoside delivery system, including a comparison of different GS types for encapsulation efficacy and the feasibility of preparation technologies.…”

Nanodrug Delivery Strategies to Signaling Pathways in Alopecia

“…Zhang et al 182 applied protopanaxadiol instead of cholesterol, a precursor for testosterone biosynthesis, to obtain liposomes. These 141.3 nm liposomes were used to load dutasteride with an encapsulation efficiency (EE%) close to 100% and a cumulative release rate of 97.74% at 24 h. These novel liposomes carrying dutasteride initiated higher mRNA expression of β-catenin, VEGF, IGF-1, and MMP3 in the DPCs of mice than conventional liposomes, which was concluded to be a possible mechanism for hair regeneration in AGA.…”