1994
DOI: 10.1016/0092-8674(94)90318-2
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A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family

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Cited by 942 publications
(878 citation statements)
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“…In this study we observed induction of PAI-1, uPA and ets1 gene expression during transformation of MDCK cells by LMP1, and interestingly HGFtreatment of MDCK cells also stimulated expression of these genes (Fafeur et al, 1997). In response to HGF, the intracellular portion of the c-Met proto-oncogene receptor becomes autophosphorylated and binds to a number of proteins, including phosphatidylinositol 3-kinase, phospholipase, Cg, pp60 c-src , Grb-2, SHC, and GAB1 (Bardelli et al, 1992;Ponzetto et al, 1994;Pelicci et al, 1995). The CTAR1 domain of LMP1, which was reported to induce expression of EGFR through the TRAF signaling pathway Devergne et al, 1996;Kaye et al, 1996), was responsible for transformation of MDCK cells.…”
Section: Discussionmentioning
confidence: 99%
“…In this study we observed induction of PAI-1, uPA and ets1 gene expression during transformation of MDCK cells by LMP1, and interestingly HGFtreatment of MDCK cells also stimulated expression of these genes (Fafeur et al, 1997). In response to HGF, the intracellular portion of the c-Met proto-oncogene receptor becomes autophosphorylated and binds to a number of proteins, including phosphatidylinositol 3-kinase, phospholipase, Cg, pp60 c-src , Grb-2, SHC, and GAB1 (Bardelli et al, 1992;Ponzetto et al, 1994;Pelicci et al, 1995). The CTAR1 domain of LMP1, which was reported to induce expression of EGFR through the TRAF signaling pathway Devergne et al, 1996;Kaye et al, 1996), was responsible for transformation of MDCK cells.…”
Section: Discussionmentioning
confidence: 99%
“…The level of auto-kinase activity of all mutants is comparable to wild type, as indicated by the fact that the labeled bands are all of similar intensity (the amounts of Tpr ± Met protein was comparable in all samples, as assessed by Western blot, data not shown). Di erences in phosphorylation of the carboxyterminal tail a ect the mobility in SDS ± PAGE of the Tpr ± Met band (Ponzetto et al, 1994). All the Tpr ± Met mutants appear to be phosphorylated on both tyrosines, as shown by the fact that their migration rate is equivalent to that of Tpr ± Met Wt .…”
Section: Construction Of Tpr ± Met Signaling Mutantsmentioning
confidence: 98%
“…Dimerization causes constitutive activation of the Met kinase, which acquires transforming and metastatic properties (Park et al, 1986;Giordano et al, 1997). Met signaling and Tpr ± Met mediated transformation are based on the activation of multiple pathways triggered by phosphorylation of two carboxy-terminal tyrosines (Y 1349 VHVNATY 1356 VNV, Ponzetto et al, 1993Ponzetto et al, , 1994Fixman et al, 1995). These tyrosine residues are part of a consensus sequence (YVH/NV) which mediates coupling of the receptor with several e ectors, including the Grb2/SoS complex (Ponzetto et al, 1994;Fixman et al, 1995), the p85 regulatory subunit of PI-3-kinase (Ponzetto et al, 1993), Stat-3 (Boccaccio et al, 1998), and the multiadaptor protein Gab1 (Weidner et al, 1996;Bardelli et al, 1997b;Nguyen et al, 1997).…”
Section: Introductionmentioning
confidence: 99%
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“…Conserved tyrosines that might be involved in phosphorylation events are localized to exons 17 ± 19. The sequence and structure of the Met receptor indicate that several of these tyrosines, when phosphorylated form a bidentate docking site for proteins that bind SH-2 domains (Ponzetto et al, 1994;Zhen et al, 1994). Tyrosines at TGACTAGTCTAGAGCCCAGAGAAACCCTGTTTCTATGTAACAA TGACTAGTCTAGAGCCATCCTGGAAAGAGGACTCTGGATTCCA TGACTAGTCTAGAGCCGCATTACTCTGTCCAGTGCATTCCTGGT TGACTAGTCTAGAGCCCACCTCCCTTCGACTTTGATCCAAGTAG TGACTAGTCTAGAGGGGTCCACAGCCAGGTGCTCAGACCACAAG TGACTAGTCTAGAGTGCCTAAAGCTGGTCTCAGCTCGGACCCTG ACTAACGCTCGAGTGAGCTGGGGCCCCTTGGGAATCCCAGAAG TGACTAGTCTAGACCTGGACCTTCTGGGATTCCCAAGGGGCC GGACAATCTGGCTCCTCTCTCCTCAT CCTTTCTCTCTGGCTTGTGGTCTGAGCACC CTCGGATCCTGTCACTGTGGCCTCA ACACGGCAATGGCACGATCA AGACTGCCCTCAAACTCAGAGATCC AGAGGTATTCTTAGCCAGGCAGCTG AGGTGCTCAGACCACAAGCCAGAGAG TGTACCAGGGCACCGGAGGAGAGGCA GATCCGGTACCAAGCTTTGAGCTGGGGCCCCTTGGAATCCCA ACCGGTGTGACCGGCAGAAGGAGTG CCCTATCTGCAGATGAAGGGGGACC TGATCCAAGCTTTGGAAAGAGTCAGACAGAGCTGGAAAGAAA TGACTATCTAGAGCCCCAGTGGGTGCGGCAGGGCTGGGGGCG TGATCCAAGCTTCCGCATTACTCTGTCCAGTGCATTCCTGGT TGACTATCTAGAAGGAACACTGTCAGGCACTAGTTCACCATG AGGAACACTGTCAGGCACTAGTTCACCATG TGACTAGTCTAGATGGAAAGAGTCAGACAGAGCTGGAAAGAAA GCCCCAGTGGGTGCGGCAGGGCTGGGGGCG TGACTAGTCTAGAGTGCCTGACAGTGTTCCTATGAAAGAGGGC CAGGACAATCTGGCTCCTCTCTCCTCATGG GCAGCGTTCTAACCTCAACCAGATGGGTTG residues 1330 and 1337 in exon 19 of the mouse Ron receptor are in analogous positions as those in Met that are involved in the docking site.…”
Section: Discussionmentioning
confidence: 99%