A multifunctional electronic suture for continuous strain monitoring and on-demand drug release

Lee, Yeontaek; Kim, Hwa-Joong; Kim, Yeon-Ju; Noh, Seungbeom; Chun, Beomsoo; Kim, Jin-Ho; Park, Charnmin; Choi, Mark; Park, Kijun; Lee, Jae Hong; Seo, Jungmok

doi:10.1039/d1nr04508c

Cited by 24 publications

(7 citation statements)

References 43 publications

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“…With the as-mentioned promoting effect in wound healing, functional conductive sutures have become another rising interest in wound healing [ [151] , [152] , [153] ]. Our research group constructed an electrically responsive and antibacterial suture (PCGT@S) with PPy in situ deposited on a polydioxanone suture pre-coated with chitosan/gelatin/tannic acid (CS-GE/TA) ( Fig.…”

Section: Electrical Signal Transmitting For Tissue Repairmentioning

confidence: 99%

“…Therefore, efforts have also been devoted in electrically driven drug-eluting sutures and electronic sutures sensing physiological variations of wound sites. Lee and coworkers [ 152 ] developed a drug release electronic suture system (DRESS) to monitor suture integrity in real time and to achieve on-demand drug release. The DRESS was composed of a AgNPs-embedded PU multifilament core and a drug-containing thermosensitive polymer shell.…”

Section: Electrical Signal Transmitting For Tissue Repairmentioning

confidence: 99%

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Conductive fibers for biomedical applications

Wei

Wang

Shan

et al. 2023

Bioactive Materials

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Section: Electrical Signal Transmitting For Tissue Repairmentioning

confidence: 99%

Section: Electrical Signal Transmitting For Tissue Repairmentioning

confidence: 99%

Conductive fibers for biomedical applications

Wei

Wang

Shan

et al. 2023

Bioactive Materials

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“…In addition, the biodegradable fiber electrode can be successfully used for suture-type implantable electronic devices, one of promising electronic devices for biomedical applications. [25,26,50] We chose to demonstrate a presented biodegradable fiber electrode as a suturable temperature sensor which can monitor the physiological temperature on target sites. Although a few noninvasive body temperature sensing methods in clinical practice, it is difficult for the existing sensing methods to precisely monitor local temperature of deep wound site in real time.…”

Section: Demonstrations Of the Biodegradable Fiber Electrode In Vario...mentioning

confidence: 99%

Surface‐Embedding of Mo Microparticles for Robust and Conductive Biodegradable Fiber Electrodes: Toward 1D Flexible Transient Electronics

et al. 2023

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Fiber-based implantable electronics are one of promising candidates for in vivo biomedical applications thanks to their unique structural advantages. However, development of fiber-based implantable electronic devices with biodegradable capability remains a challenge due to the lack of biodegradable fiber electrodes with high electrical and mechanical properties. Here, a biocompatible and biodegradable fiber electrode which simultaneously exhibits high electrical conductivity and mechanical robustness is presented. The fiber electrode is fabricated through a facile approach that incorporates a large amount of Mo microparticles into outermost volume of a biodegradable polycaprolactone (PCL) fiber scaffold in a concentrated manner. The biodegradable fiber electrode simultaneously exhibits a remarkable electrical performance (≈43.5 𝛀 cm −1 ), mechanical robustness, bending stability, and durability for more than 4000 bending cycles based on the Mo/PCL conductive layer and intact PCL core in the fiber electrode. The electrical behavior of the biodegradable fiber electrode under the bending deformation is analyzed by an analytical prediction and a numerical simulation. In addition, the biocompatible properties and degradation behavior of the fiber electrode are systematically investigated. The potential of biodegradable fiber electrode is demonstrated in various applications such as an interconnect, a suturable temperature sensor, and an in vivo electrical stimulator.

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“…Accordingly, approaches incorporating these biomolecules within bioelectronic devices have been widely studied. 58,59 In this section, we discuss two design strategies for biomolecule incorporation: drug delivery systems and biomolecule immobilization. 3.2.1.…”

Section: Biocompatibilitymentioning

confidence: 99%

“…This can be realized by using various biomolecules, such as therapeutic, antibacterial, and anti-inflammatory drugs. Accordingly, approaches incorporating these biomolecules within bioelectronic devices have been widely studied. , In this section, we discuss two design strategies for biomolecule incorporation: drug delivery systems and biomolecule immobilization.…”

Section: Biocompatibilitymentioning

confidence: 99%

Functional Bioelectronic Materials for Long-Term Biocompatibility and Functionality

Park

Lee

Kim

et al. 2022

ACS Appl. Electron. Mater.

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Wearable and implantable bioelectronics have received a great deal of interest since the need for personalized healthcare systems has arisen. Bioelectronics are designed to detect biological signals and apply medical treatments, thereby enabling patients to monitor and manage their health conditions. However, current bioelectronics lack long-term stability, biocompatibility, and functionality after implantation into the human body. In particular, the intrinsically different natures of the devices and human tissue result in low device–tissue compatibility. The obstacles for this can be defined as (1) physical, (2) biological, and (3) interfacial. The mechanical mismatch between rigid device materials and soft tissue results in physical incompatibility, which causes user discomfort and scar tissue formation. In addition, devices can show poor biocompatibility since the device materials are recognized as foreign bodies by the immune system. Accordingly, the applied devices can be toxic and/or induce an undesirable immune response and inflammation. Last, tissue environments are moist, irregular, and dynamic, which causes poor interfacial compatibility between the device and the human body. Herein, we describe various recent strategies to overcome limitations in the physical, biological, and interfacial compatibility of bioelectronics for long-term functionality in vivo. Moreover, in the last part of the review, we mention current limitations and future perspectives of bioelectronics for commercialization.

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A multifunctional electronic suture for continuous strain monitoring and on-demand drug release

Abstract: A schematic of the drug release electronic suture system (DRESS) with a conductive fiber strain sensor core and a thermoresponsive polymer shell containing drugs.

Cited by 24 publications

References 43 publications

Conductive fibers for biomedical applications

Conductive fibers for biomedical applications

Surface‐Embedding of Mo Microparticles for Robust and Conductive Biodegradable Fiber Electrodes: Toward 1D Flexible Transient Electronics

Functional Bioelectronic Materials for Long-Term Biocompatibility and Functionality

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