A multifunctional nanomedicine platform for co-delivery of methotrexate and mild hyperthermia towards breast cancer therapy

Ong, Yong Sze; Bañobre‐López, Manuel; Lima, Sofia A. Costa

doi:10.1016/j.msec.2020.111255

Cited by 34 publications

(24 citation statements)

References 45 publications

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“…The treatment's success depends on the following factors: (1) the cancerous cells must be selectively targeted; (2) the SPIONs' penetration inside the cancerous cells should be facile; (3) the encapsulation of the SPIONs in the unhealthy cells has to be completed; (4) SPIONs must be biocompatible and non-toxic; (5) the treatment should be feasible from the clinical point of view; (6) the treatment has to be a general one, and different types of tumors can be treated, even metastatic ones [168,169].…”

Section: Magnetic Hyperthermiamentioning

confidence: 99%

Magnetic Nanoparticles Used in Oncology

et al. 2021

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Recently, magnetic nanoparticles (MNPs) have more and more often been used in experimental studies on cancer treatments, which have become one of the biggest challenges in medical research. The main goal of this research is to treat and to cure advanced or metastatic cancer with minimal side effects through nanotechnology. Drug delivery approaches take into account the fact that MNPs can be bonded to chemotherapeutical drugs, nucleic acids, synthetized antibodies or radionuclide substances. MNPs can be guided, and different treatment therapies can be applied, under the influence of an external magnetic field. This paper reviews the main MNPs’ synthesis methods, functionalization with different materials and highlight the applications in cancer therapy. In this review, we describe cancer cell monitorization based on different types of magnetic nanoparticles, chemotherapy, immunotherapy, magnetic hyperthermia, gene therapy and ferroptosis. Examples of applied treatments on murine models or humans are analyzed, and glioblastoma cancer therapy is detailed in the review. MNPs have an important contribution to diagnostics, investigation, and therapy in the so called theranostics domain. The main conclusion of this paper is that MNPs are very useful in different cancer therapies, with limited side effects, and they can increase the life expectancy of patients with cancer drug resistance.

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Section: Magnetic Hyperthermiamentioning

confidence: 99%

Magnetic Nanoparticles Used in Oncology

et al. 2021

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“…Methotrexate (MTX), a folic acid analogue, is a highly potent inhibitor of the folate pathway that induces cell apoptosis, and is widely used for the treatment of rheumatoid arthritis and acute leukemia [ 26 ]. Owing to its special characteristic, many experimental studies have explored its use in the treatment of cancer [ 27 ]. MTX can inhibit dihydrofolate reductase enzyme that helps produce tetrahydrofolate and its by-products, which are essential for the growth of tumor cells [ 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

“…Owing to its special characteristic, many experimental studies have explored its use in the treatment of cancer [ 27 ]. MTX can inhibit dihydrofolate reductase enzyme that helps produce tetrahydrofolate and its by-products, which are essential for the growth of tumor cells [ 28 , 29 ]. Folate receptor (FR) is a glycosyl phosphatidylinositol-linked protein has low expression in normal tissues, but is overexpressed in certain malignant cells such as those of BC [ 30 ].…”

Section: Introductionmentioning

confidence: 99%

Hierarchical drug release designed Au @PDA-PEG-MTX NPs for targeted delivery to breast cancer with combined photothermal-chemotherapy

Cao

et al. 2021

J Nanobiotechnol

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Breast cancer (BC) is the most frequently diagnosed cancer with a low survival rate and one of the major causes of cancer-related death. Methotrexate (MTX) is an anti-tumor drug used in the treatment of BC. Poor dispersion in water and toxic side effects limit its clinical application. Gold nanoparticles (AuNPs), owing to their specific structures and unique biological and physiochemical properties, have emerged as potential vehicles for tumor targeting, bioimaging and cancer therapy. An innovative nano drug-loading system (Au @PDA-PEG-MTX NPs) was prepared for targeted treatment of BC. Au @PDA-PEG-MTX NPs under near infra-red region (NIR) irradiation showed effective photothermal therapy against MDA-MB-231 human BC cells growth in vitro by inducing apoptosis through triggering reactive oxygen species (ROS) overproduction and generating excessive heat. In vivo studies revealed deep penetration ability of Au @PDA-PEG-MTX NPs under NIR irradiation to find application in cancer-targeted fluorescence imaging, and exhibited effective photothermal therapy against BC xenograft growth by inducing apoptosis. Histopathological analysis, cellular uptake, cytotoxicity assay, and apoptosis experiments indicated that Au @PDA-PEG-MTX NPs possessed a good therapeutic effect with high biocompatibility and fewer side effects. This Au NPs drug-loading system achieved specific targeting of MTX to BC cells by surface functionalisation, fluorescence imaging under laser irradiation, combined photothermal-chemotherapy, and pH- and NIR- triggered hierarchical drug release.

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“…Methotrexate (MTX), a folic acid analog is a highly potent antagonist on folate pathway to induce cell apoptosis, who is widely used for the treatment of rheumatoid arthritis and acute leukemia [26]. Due to its special characteristic, many experimental researches tend to explore its treatment for cancer [27]. MTX as a folic acid analog can inhibit dihydrofolate reductase (DHFR), an enzyme that helps produce tetrahydrofolate and its by-products, both of which are essential for the growth of tumor cells [28,29].…”

Section: Introductionmentioning

confidence: 99%

“…Due to its special characteristic, many experimental researches tend to explore its treatment for cancer [27]. MTX as a folic acid analog can inhibit dihydrofolate reductase (DHFR), an enzyme that helps produce tetrahydrofolate and its by-products, both of which are essential for the growth of tumor cells [28,29].…”

Section: Introductionmentioning

confidence: 99%

Hierarchical Drug Release Designed Au @PDA-PEG-MTX NPs for Targeted Delivery to Breast Cancer with Combined Photothermal-chemotherapy

Cao

et al. 2021

Preprint

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Breast cancer (BC) is the frequently diagnosed cancer and one of the deadliest causes of cancer-related death with a severe survival rate. Methotrexate (MTX) is an anti-tumor drug used in the treatment of BC. The poor dispersion in water and toxic side effects limit its clinical application. Gold nanoparticles (AuNPs), due to their specific structures and unique biological and physiochemical properties, have emerged as attractive candidates as vehicles for tumor targeting, bio-imaging and therapy. An innovative nano drug-loading system (Au @PDA-PEG-MTX NPs) was prepared for targeted treatment of BC. Au @PDA-PEG-MTX NPs under near infra-red region (NIR) irradiation showed effective photothermal therapy against MDA-MB-231 human BC cells growth in vitro by inducing apoptosis through triggering reactive oxygen species (ROS) overproduction and generating excessive heat. In vivo studies revealed that Au @PDA-PEG-MTX NPs under NIR irradiation showed deep penetration and cancer-targeted fluorescence imaging application and strong photothermal therapy against BC xenograft growth in vivo by induction of apoptosis. Analysis of histopathology, cellular uptake, cytotoxicity assay, apoptosis experiment indicated that Au @PDA-PEG-MTX NPs had a good therapeutic effect with high biocompatibility and less side effect. This Au NPs drug-loading system achieved specific BC targeting ability by surface decoration of MTX, NIR laser irradiation for fluorescence imaging and combined photothermal-chemotherapy as well as pH- and NIR- triggered hierarchical drug release.

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A multifunctional nanomedicine platform for co-delivery of methotrexate and mild hyperthermia towards breast cancer therapy

Cited by 34 publications

References 45 publications

Magnetic Nanoparticles Used in Oncology

Magnetic Nanoparticles Used in Oncology

Hierarchical drug release designed Au @PDA-PEG-MTX NPs for targeted delivery to breast cancer with combined photothermal-chemotherapy

Hierarchical Drug Release Designed Au @PDA-PEG-MTX NPs for Targeted Delivery to Breast Cancer with Combined Photothermal-chemotherapy

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