A multifunctional nanoparticulate theranostic system with simultaneous chemotherapeutic, photothermal therapeutic, and MRI contrast capabilities

Zhang, Ming; Yilmaz, Türker; Boztas, Ali Ozgur; Karakuzu, Ozgur; Bang, Woo Young; Yegin, Yagmur; Luo, Zhiping; Lenox, M.; Cisneros‐Zevallos, Luis; Akbulut, Mustafa

doi:10.1039/c5ra27792b

Cited by 15 publications

(6 citation statements)

References 91 publications

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“…Several aliquots of dialysate mixture were collected at different times and immediately submitted to UV acquisitions, and then replaced in the mixture of the dialysis experiment. The calibration curve employed for the quantitative conversion of data over time was taken from existing literature ( y = 0.04 x − 0.0626; R 2 = 0.9931) [ 56 , 57 ].…”

Section: Methodsmentioning

confidence: 99%

Albumin and Hyaluronic Acid-Coated Superparamagnetic Iron Oxide Nanoparticles Loaded with Paclitaxel for Biomedical Applications

et al. 2017

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Super paramagnetic iron oxide nanoparticles (SPION) were augmented by both hyaluronic acid (HA) and bovine serum albumin (BSA), each covalently conjugated to dopamine (DA) enabling their anchoring to the SPION. HA and BSA were found to simultaneously serve as stabilizing polymers of Fe3O4·DA-BSA/HA in water. Fe3O4·DA-BSA/HA efficiently entrapped and released the hydrophobic cytotoxic drug paclitaxel (PTX). The relative amount of HA and BSA modulates not only the total solubility but also the paramagnetic relaxation properties of the preparation. The entrapping of PTX did not influence the paramagnetic relaxation properties of Fe3O4·DA-BSA. Thus, by tuning the surface structure and loading, we can tune the theranostic properties of the system.

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Section: Methodsmentioning

confidence: 99%

Albumin and Hyaluronic Acid-Coated Superparamagnetic Iron Oxide Nanoparticles Loaded with Paclitaxel for Biomedical Applications

et al. 2017

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“…encapsulated SPIO, gold nanoparticles and paclitaxel (PTX) in PEO- b -PCL copolymer through a flash nanoprecipitation approach [48]. The resultant PTX-Au-IO nanoparticles provided concurrent chemotherapy and PTT.…”

Section: Spio-delivered Photothermal Therapymentioning

confidence: 99%

Next-generation superparamagnetic iron oxide nanoparticles for cancer theranostics

Nejadnik

Daldrup‐Link

2017

Drug Discovery Today

123

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Superparamagnetic nanoparticles of iron oxides (SPIO) have been intensively studied for the development of contrast agents in magnetic resonance imaging (MRI). First generation SPIO had diagnostic capabilities only, while a new generation of SPIO have multifunctional characteristics for combined therapeutic and diagnostic applications. These theranostic nanoparticles hold great potential for image-guided cancer therapies. Especially, polymer-coated theranostic SPIO have enjoyed increasing attention due to good biocompatibility, biodegradability and versatile functionality endowed by polymeric matrices. This review provides an overview of recently developed polymer-coated multifunctional SPIO for cancer theranostics and discusses current challenges and future perspectives.

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“…Therefore, another interesting strategy involves the combination of therapy associated with luminescent elements for application in diagnostic imaging. Multifunctional systems with an emphasis on therapy and diagnosis simultaneously, known as theranostic systems, have shown promise in several studies [ 20 ]. Several luminescent agents such as rare earth elements have been explored for this application, due to the outstanding optical, magnetic and X-ray attenuation properties, as well as the radioactivity of its isotopes [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

pH-Sensitive Hybrid System Based on Eu3+/Gd3+ Co-Doped Hydroxyapatite and Mesoporous Silica Designed for Theranostic Applications

et al. 2023

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Nanomaterials such as pH-responsive polymers are promising for targeted drug delivery systems, due to the difference in pH between tumor and healthy regions. However, there is a significant concern about the application of these materials in this field due to their low mechanical resistance, which can be attenuated by combining these polymers with mechanically resistant inorganic materials such as mesoporous silica nanoparticles (MSN) and hydroxyapatite (HA). Mesoporous silica has interesting properties such as high surface area and hydroxyapatite has been widely studied to aid in bone regeneration, providing special properties adding multifunctionality to the system. Furthermore, fields of medicine involving luminescent elements such as rare earth elements are an interesting option in cancer treatment. The present work aims to obtain a pH-sensitive hybrid system based on silica and hydroxyapatite with photoluminescent and magnetic properties. The nanocomposites were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), nitrogen adsorption methods, CHN elemental analysis, Zeta Potential, scanning electron microscopy (SEM), and transmission electron microscopy (TEM), vibrational sample magnetometry (VSM), and photoluminescence analysis. Incorporation and release studies of the antitumor drug doxorubicin were performed to evaluate the potential use of these systems in targeted drug delivery. The results showed the luminescent and magnetic properties of the materials and showed suitable characteristics for application in the release of pH-sensitive drugs.

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A multifunctional nanoparticulate theranostic system with simultaneous chemotherapeutic, photothermal therapeutic, and MRI contrast capabilities

Abstract: Herein, a single-step, scalable approach for preparing a multifunctional, theranostic drug delivery system made out of paclitaxel, iron oxide nanoparticles, gold nanoparticles, and poly(ethylene oxide)-b-poly(ε-caprolactone) is reported.

Cited by 15 publications

References 91 publications

Albumin and Hyaluronic Acid-Coated Superparamagnetic Iron Oxide Nanoparticles Loaded with Paclitaxel for Biomedical Applications

Albumin and Hyaluronic Acid-Coated Superparamagnetic Iron Oxide Nanoparticles Loaded with Paclitaxel for Biomedical Applications

Next-generation superparamagnetic iron oxide nanoparticles for cancer theranostics

pH-Sensitive Hybrid System Based on Eu3+/Gd3+ Co-Doped Hydroxyapatite and Mesoporous Silica Designed for Theranostic Applications

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