A multifunctional nanoplatform based on mesoporous silica nanoparticles for imaging-guided chemo/photodynamic synergetic therapy

Liu, Yadan; Liu, Xiaolin; Xiao, Yue; Chen, Fangman; Xiao, Fajun

doi:10.1039/c7ra04549b

Cited by 43 publications

(41 citation statements)

References 55 publications

(71 reference statements)

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“…The synergistic combination of phototherapy and antimicrobials delivery against bacterial infection using MSNs constitutes a promising alternative to conventional antibiotic treatments [ 97 , 98 ]. Following this approach, Lee and co-workers developed an antimicrobial trio-hybrid nanosystem consisting of Cu(II)-impregnated MSNs loaded with curcumin (CUR) and externally decorated with Ag NPs [ 97 ].…”

Section: Stimuli-responsive Antimicrobials Deliverymentioning

confidence: 99%

“…In another report, Xiao and co-workers described the preparation of a multifunctional nanoplatform based on MSNs for imaging guided antimicrobial/photodynamic synergetic therapy ( Figure 10 ) [ 98 ]. Firstly, carbon dots (C-dots) and rose bengal (RB) were embedded in core-shell MSNs affording MSN@C-dots/RB nanosystem.…”

Section: Stimuli-responsive Antimicrobials Deliverymentioning

confidence: 99%

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Targeted Stimuli-Responsive Mesoporous Silica Nanoparticles for Bacterial Infection Treatment

Colilla

Vallet‐Regí

2020

IJMS

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The rise of antibiotic resistance and the growing number of biofilm-related infections make bacterial infections a serious threat for global human health. Nanomedicine has entered into this scenario by bringing new alternatives to design and develop effective antimicrobial nanoweapons to fight against bacterial infection. Among them, mesoporous silica nanoparticles (MSNs) exhibit unique characteristics that make them ideal nanocarriers to load, protect and transport antimicrobial cargoes to the target bacteria and/or biofilm, and release them in response to certain stimuli. The combination of infection-targeting and stimuli-responsive drug delivery capabilities aims to increase the specificity and efficacy of antimicrobial treatment and prevent undesirable side effects, becoming a ground-breaking alternative to conventional antibiotic treatments. This review focuses on the scientific advances developed to date in MSNs for infection-targeted stimuli-responsive antimicrobials delivery. The targeting strategies for specific recognition of bacteria are detailed. Moreover, the possibility of incorporating anti-biofilm agents with MSNs aimed at promoting biofilm penetrability is overviewed. Finally, a comprehensive description of the different scientific approaches for the design and development of smart MSNs able to release the antimicrobial payloads at the infection site in response to internal or external stimuli is provided.

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Section: Stimuli-responsive Antimicrobials Deliverymentioning

confidence: 99%

Section: Stimuli-responsive Antimicrobials Deliverymentioning

confidence: 99%

Targeted Stimuli-Responsive Mesoporous Silica Nanoparticles for Bacterial Infection Treatment

Colilla

Vallet‐Regí

2020

IJMS

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“…Xiao and co‐workers prepared a multifunctional nanoplatform based on MS NPs for imaging guided chemo/photodynamic synergetic therapy ( Figure ) . In a first step, carbon dots (C‐dots) were prepared and then embedded in MS NPs (MS@C‐dots).…”

Section: Ms In Antibacterial Applicationsmentioning

confidence: 99%

Mesoporous Silica‐Based Materials with Bactericidal Properties

Bernardos

Piacenza

Sancenón

et al. 2019

Small

146

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Bacterial infections are the main cause of chronic infections and even mortality. In fact, due to extensive use of antibiotics and, then, emergence of antibiotic resistance, treatment of such infections by conventional antibiotics has become a major concern worldwide. One of the promising strategies to treat infection diseases is the use of nanomaterials. Among them, mesoporous silica materials (MSMs) have attracted burgeoning attention due to high surface area, tunable pore/particle size, and easy surface functionalization. This review discusses how one can exploit capacities of MSMs to design and fabricate multifunctional/controllable drug delivery systems (DDSs) to combat bacterial infections. At first, the emergency of bacterial and biofilm resistance toward conventional antimicrobials is described and then how nanoparticles exert their toxic effects upon pathogenic cells is discussed. Next, the main aspects of MSMs (e.g., physicochemical properties, multifunctionality, and biosafety) which one should consider in the design of MSM‐based DDSs against bacterial infections are introduced. Finally, a comprehensive analysis of all the papers published dealing with the use of MSMs for delivery of antibacterial chemicals (antimicrobial agents functionalized/adsorbed on mesoporous silica (MS), MS‐loaded with antimicrobial agents, gated MS‐loaded with antimicrobial agents, MS with metal‐based nanoparticles, and MS‐loaded with metal ions) is provided.

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“…The CQDs were synthesized according to a earlier reported procedure (Liu et al 2017). In brief, 1 g of citric acid and 2 g of urea were dissolved in 20 mL of DMF to obtain a clear solution, and it was transferred into the 50 mL stainless steel for autoclave to be heated at 180 C for 6 h hydrothermally.…”

Section: Synthesis Of Carbon Quantum Dotmentioning

confidence: 99%

Combined photodynamic-chemotherapy investigation of cancer cells using carbon quantum dot-based drug carrier system

Vinothini

Ramesh

et al. 2020

Drug Delivery

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A multifunctional nanoplatform based on mesoporous silica nanoparticles for imaging-guided chemo/photodynamic synergetic therapy

Abstract: A multifunctional nanoplatform, MSN@C-dots/RB, is fabricated for drug delivery and imaging-guided chemo/photodynamic synergistic therapy.

Cited by 43 publications

References 55 publications

Targeted Stimuli-Responsive Mesoporous Silica Nanoparticles for Bacterial Infection Treatment

Targeted Stimuli-Responsive Mesoporous Silica Nanoparticles for Bacterial Infection Treatment

Mesoporous Silica‐Based Materials with Bactericidal Properties

Combined photodynamic-chemotherapy investigation of cancer cells using carbon quantum dot-based drug carrier system

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