A Multifunctional Smart Soft Contact Lens Device Enabled by Nanopore Thin Film for Glaucoma Diagnostics and <i>In Situ</i> Drug Delivery

Song, Chao; Ben‐Shlomo, Gil; Que, Long

doi:10.1109/jmems.2019.2927232

Cited by 39 publications

(45 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Traditionally, contact lenses have been used for treating vision impairments such as myopia, hyperopia, and astigmatism. More recently, electronic contact lenses have been considered as an effective noninvasive platform for detecting and diagnosing vital human signs, particularly for the detection of glucose levels in diabetic patients, as well as glaucoma . Thanks to the integration of biotechnology, information technology, and microelectronics on the contact lens platform, various biosensors and electrochemical sensors have been developed on lenses for the detection of these biomarkers .…”

Section: Introductionmentioning

confidence: 99%

Electronic Contact Lens: A Platform for Wireless Health Monitoring Applications

Yuan

Das

Ghannam

et al. 2020

Advanced Intelligent Systems

View full text Add to dashboard Cite

Electronic contact lenses are used for noninvasively monitoring vital human signs and medical parameters. However, maintaining a secure communications connection and a self‐sustainable power source are still looming challenges. Herein, a proof‐of‐concept electronic contact lens is demonstrated that includes a spiral antenna with its wireless circuit unit for data telemetry, a rectifier circuit for power conditioning, and a micro‐light‐emitting diode (μLED) as a load. The spiral antenna with its rectifying circuit is designed considering operation in the industrial, scientific, and medical (ISM) band of 2.4 GHz. The spiral coil with an inner diameter of 10 mm, an outer diameter of 12 mm, and a wire width of 0.2 mm is fabricated on a donut‐shaped flexible polyimide substrate. For biocompatibility purposes, polyimide is used as the contact lens substrate and polydimethylsiloxane (PDMS) is used for encapsulation. A 3D‐printed eye model is developed for accurately shaping the curvature of the PDMS‐encapsulated contact lens. The reflection coefficient (S11) of the fabricated antenna is tested in different conditions and on an eye model to mimic the liquid condition of the human eye. In a wide range of conditions, a minimum of −20 dB reflection coefficient (S11) is obtained.

show abstract

Section: Introductionmentioning

confidence: 99%

Electronic Contact Lens: A Platform for Wireless Health Monitoring Applications

Yuan

Das

Ghannam

et al. 2020

Advanced Intelligent Systems

View full text Add to dashboard Cite

show abstract

“…The physical link of these implants to IOLs may overcome the problem and guarantee their correct positioning in the anterior chamber of the eye. Despite being more commonly applied on IOLs [ 23 , 27 , 117 , 118 , 119 ], examples of incorporated reservoirs were also implemented on CLs [ 120 , 121 , 122 , 123 , 124 , 125 , 126 ]. Drug reservoirs are usually constituted of biodegradable polymers: the material must be biocompatible, and its degradation products should not cause chronic inflammation or toxicity in the ocular tissues [ 47 ].…”

Section: Drug Loading Methodsmentioning

confidence: 99%

“…However, as rabbits were not responding to the latanoprost therapy, the device was also tested on glaucomatous monkeys: the results evidenced that the IOP lowering efficacy was as least equal to the daily administration of eye drops. Song et al [ 126 ] engineered multifunctional CLs, which were able to measure IOP, in order detect glaucoma biomarkers and deliver timolol for one month in vitro : an aluminum oxide nanoporous thin film with a central hole was incorporated in PDMS lenses, and served both as a power-free sensor and a drug reservoir with a prolonged release over time.…”

Section: Lenses For Ocular Diseasesmentioning

confidence: 99%

Therapeutic Ophthalmic Lenses: A Review

2020

View full text Add to dashboard Cite

An increasing incidence of eye diseases has been registered in the last decades in developed countries due to the ageing of population, changes in lifestyle, environmental factors, and the presence of concomitant medical conditions. The increase of public awareness on ocular conditions leads to an early diagnosis and treatment, as well as an increased demand for more effective and minimally invasive solutions for the treatment of both the anterior and posterior segments of the eye. Despite being the most common route of ophthalmic drug administration, eye drops are associated with compliance issues, drug wastage by lacrimation, and low bioavailability due to the ocular barriers. In order to overcome these problems, the design of drug-eluting ophthalmic lenses constitutes a non-invasive and patient-friendly approach for the sustained drug delivery to the eye. Several examples of therapeutic contact lenses and intraocular lenses have been developed, by means of different strategies of drug loading, leading to promising results. This review aims to report the recent advances in the development of therapeutic ophthalmic lenses for the treatment and/or prophylaxis of eye pathologies (i.e., glaucoma, cataract, corneal diseases, or posterior segment diseases) and it gives an overview of the future perspectives and challenges in the field.

show abstract

“…Recently a contact lens sensor ( Figure 14 a–c) for detecting IL-12p70 has been developed [ 106 ]. The biomarker is monitored by measuring the optical reflection signal from the nanopore thin film sensor embedded in the contact lens.…”

Section: Sensors For Neuro-dds Biomarker Detectionmentioning

confidence: 99%

“… ( a , b ) Contact lens with embedded sensors for detection of glaucoma biomarkers; ( c ) SEM images showing the nanopore in the sensors; ( d ) surface functionalization of the sensors on contact lens; ( e ) representative measured optical signals from a sensor on the contact lens with artificial tear and 1 pg/mL IL 12p70 spiked in artificial tear and ( f ) measured optical signals from the sensor with increased concentrations of IL 12p70 in artificial tear. Reproduced from reference [ 106 ] with permission from IEEE. …”

Section: Figurementioning

confidence: 99%

On-Chip Detection of the Biomarkers for Neurodegenerative Diseases: Technologies and Prospects

et al. 2020

Self Cite

View full text Add to dashboard Cite

Alzheimer’s disease (AD), Parkinson’s disease (PD) and glaucoma are all regarded as neurodegenerative diseases (neuro-DDs) because these diseases are highly related to the degeneration loss of functions and death of neurons with aging. The conventional diagnostic methods such as neuroimaging for these diseases are not only expensive but also time-consuming, resulting in significant financial burdens for patients and public health challenge for nations around the world. Hence early detection of neuro-DDs in a cost-effective and rapid manner is critically needed. For the past decades, some chip-based detection technologies have been developed to address this challenge, showing great potential in achieving point-of-care (POC) diagnostics of neuro-DDs. In this review, chip-based detection of neuro-DDs’ biomarkers enabled by different transducing mechanisms is evaluated.

show abstract

A Multifunctional Smart Soft Contact Lens Device Enabled by Nanopore Thin Film for Glaucoma Diagnostics and In Situ Drug Delivery

Cited by 39 publications

References 34 publications

Electronic Contact Lens: A Platform for Wireless Health Monitoring Applications

Electronic Contact Lens: A Platform for Wireless Health Monitoring Applications

Therapeutic Ophthalmic Lenses: A Review

On-Chip Detection of the Biomarkers for Neurodegenerative Diseases: Technologies and Prospects

Contact Info

Product

Resources

About